Liver Endocrine Function - Anatomy & Physiology
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The liver produces some very important hormones:
| Hormone | Regulation and Production | Action |
|---|---|---|
| Insulin-Like Growth Factor 1 (IGF-1) | Growth Hormone released from the pituitary gland binds to receptors on liver cells which causes them to synthesise and secrete IGF-1. | IGF-1 has insulin-like effects as it can bind to the Insulin Receptor, and is also the stimulus for growth in the body. Almost all cell types respond to IGF-1. |
| Angiotensinogen | Angiotensinogen is the precursor to angiotensin 1, and is part of the Renin-Angiotensin-Aldosterone system. | Is converted to Angiotensin by renin which in turn is converted to other substrates which act to raise blood pressure during hypotension. |
| Thrombopoietin | A negative feedback system operates to maintain this hormone at an appropriate level. | Causes bone marrow precursor cells to develop into Megakaryocytes, platelet precursors. |
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