WikiVet English - User contributions [en]

Fasciola hepatica

2010-11-23T20:15:05Z

Cryptic: /* Introduction */

{{review}}

{{Taxobox
|name =''Fasciola hepatica
|kingdom =Animalia
|phylum =Platyhelminthes
|class =[[:Category:Trematodes|Trematoda]]
|sub-class =Digenea
|order =Echinostomida
|super-family =
|family =Fasciolidae
|sub-family =
|genus =Fasciola
|species =''Fasciola hepatica
}}

Also known as: '''''Liver Fluke

==Introduction==

''Fasciola Hepatica'' is an hepatic parasite of the class [[:Category:Trematodes|Trematoda]], found mainly in ruminants, namely cows, sheep and goats, but also known to affect horses, pigs, deer and man. It is found Worldwide, and within the UK, with its prevalence ever increasing. It is responsible for a 10-15% production loss in each infected animal, as it affects meat, milk and wool production, so is of huge economic consequence.

''Fasciola Hepatica'' has a definitive ruminant mammalian host and an intermediate molluscan host (indirect life cycle). Within Europe the intermediate host is almost exclusively the amphibious snail ''Galba truncatula'' (previously called ''Lymnaea truncatulata''). The snail habitat is crucial to the survival of the parasite, so wet conditions are favourable to the development and spread of ''Fasciola hepatica''.

[[Image:Fasciola hepatica.jpg|400px|thumb|right|''Fasciola hepatica'' Adam Cuerden 2007, Wikimedia Commons]]

==Life Cycle==

Adult flukes in the bile ducts shed '''eggs''' directly into the bile, which then subsequently enter the intestine. Eggs are then passed out in the faeces of the mammalian host, where they develop and hatch releasing motile ciliated '''miracidia'''. These require 9-10 days at optimal temperatures, of around 22-26 degrees. The miracidium have a short life and must locate a suitable snail, the intermediate host, within approximately 3 hours if they are to be effective and continue the life cycle.

If successful, the miracidium will then develop into '''sporocysts''', then enter the '''redial stages''' to the final stages within the intermediate host, which is development into '''cercaria'''. These cercaria are then released from the snail, and attach to surfaces such as the tips of grass. Here they encyst and form '''metacercaria'''. This represents the infective stage of the lifecycle.

Development from miracidium into metacercariae takes around 6-7 weeks under favourable conditions, however, this period can be much longer in unfavourable conditions.

Upon ingestion by the final or definitive host from the grass, metacercariae excyst to present as immature flukes in the small intestine. These then migrate across the peritoneal cavity over a period of roughly one week, and invade the liver. Larvae continue to migrate within the hepatic parenchyma, becoming more destructive as they grow to a length of up to one centimetre. The young liver flukes migrate through the liver for around 6-8 weeks before entering the bile ducts where they mature to adults and begin to produce eggs. They may also migrate into the gall bladder, where they reach full sexual maturity.

The prepatent period of ''Fasciola hepatica'' is 10-12 weeks. In untreated sheep it may survive and continue to infect for many years. In cattle it is usually less than 1 year.

==Identification==

The egg is relatively large; around 140μm x 70μm. It is oval shaped, with a thin outer shell, and is browny-yellow.

The fully mature adult fluke is a dark brown colour, and around 3cm in length.

==Snail biology==
[[Image:Lymnaea truncatula.jpg|thumb|right|150px|''Lymnaea truncatula'' - Francisco Welter Schultes, Wikimedia Commons]]
=== ''Lymnaea truncatula'' ===
''Lympnea truncatula'' is around 5-10mm long. It has a distinctive brown-black shell, with 5-6 spirals present on the outer surface. The first spiral is approximately half the total length of the snail.

It feeds on green slime, and when this is present in abundance, they may multiply rapidly.

Most die in the British winter, due to the harsh, cold conditions, but they may survive in milder winters. Survivors will lay eggs in spring, which will hatch in June.

===Habitats===
''Lymnaea'' are found predominantly in muddy areas, but do not survive well in highly acidic soils. Habitats may be permanent; seen in dry summers or temporary; found in wet summers.

===Epidemiology===
Wet summers increase both the number of snail habitats and the hatching of fluke eggs, leading to many infected snails. These in turn shed many cercariae, which form a high density of metacercariae on herbage to increase the risk of fasciolosis. Conversely, in dry summers, fewer fluke eggs hatch and snails are restricted to their permanent habitats. Fewer snails become infected and cercariae and metacercariae numbers are low and confined to the areas where snails can survive. The risk of fasciolosis is therefore reduced.

In temperate areas, there are two superimposed epidemiological cycles, known as the summer and winter infections of the snail. On mainland Britain, the summer cycle predominates as a high proportion of snails perish during the winter, but very occasionally, weather sequences allow the winter cycle to affect the pattern of disease. On the west coast of Ireland, the winter cycle of events determines the timing of clinical outbreaks.

==== Summer infection of the snail ====
The fluke eggs passed in spring will hatch in June. This coincides with the hatching of the snail. The miracidia will then infect the newly hatched snails, mature and then multiply within the snail hepatopancreas during the summer months.

The cercariae are shed from late August onwards. The metacercariae develop and are ingested by a host; the sheep for example. The immature flukes then migrate through the liver, causing acute disease between the months of September and November, or chronic disease from January onwards.

====Winter infection of the snail====
In this case the fluke eggs are passed in the late summmer, which then infect the snails. Environmental conditions play a vital role in the success of the fluke development. Temperatures below 10 degrees will see the development being haltered, and the flukes will remain trapped in the hibernating snails throughout the winter. Development will then resume when temperatures rise above 10 degrees. The cercariae are then shed from July, and disease may be seen from August onwards.

==Pathogenesis==

The severity of the infection, [[Fasciolosis]], is mainly dependent on the number of metacercariae ingested. The pathogenesis is often described as two-fold. The first stage occurring when the parasite migrates through the liver parenchyma, causing liver damage and haemorrhage. The second phase occurs when the parasite is in the bile ducts, and damage is a result of the haematophagic activity of the adult flukes.

==Test yourself with the Trematodes Flashcards==

[[Trematodes_Flashcards|Trematodes Flashcards]]

==Literature Search==
[[File:CABI logo.jpg|left|90px]]

Use these links to find recent scientific publications via CAB Abstracts (log in required unless accessing from a subscribing organisation).
 
[http://www.cabdirect.org/search.html?rowId=1&options1=AND&q1=%22Fasciola+hepatica%22&occuring1=title&rowId=2&options2=AND&q2=&occuring2=freetext&rowId=3&options3=AND&q3=&occuring3=freetext&publishedstart=2000&publishedend=yyyy&calendarInput=yyyy-mm-dd&la=any&it=any&show=all&x=46&y=7 ''Fasciola hepatica'' publications since 2000]

==References==

Taylor, M.A, Coop, R.L., Wall,R.L. (2007) '''Veterinary Parasitology''' ''Blackwell Publishing''

G.L. Pritchard et al., Emergence of fasciolosis in cattle in East Anglia, ''The Veterinary Record'', November 5, 2005.

[[Category:Trematodes]]

[[Category:Liver Trematodes]]

[[Category:Cattle]][[Category:Sheep]][[Category:Horse Parasites]][[Category:Pig]][[Category:Goat]]

[[Category:Expert_Review]]

Fasciola hepatica

2010-11-23T20:13:40Z

Cryptic: /* Introduction */

{{review}}

{{Taxobox
|name =''Fasciola hepatica
|kingdom =Animalia
|phylum =Platyhelminthes
|class =[[:Category:Trematodes|Trematoda]]
|sub-class =Digenea
|order =Echinostomida
|super-family =
|family =Fasciolidae
|sub-family =
|genus =Fasciola
|species =''Fasciola hepatica
}}

Also known as: '''''Liver Fluke

==Introduction==

''Fasciola Hepatica'' is an hepatic parasite of the class [[:Category:Trematodes|Trematoda]], found mainly in ruminants, namely cows, sheep and goats, but also known to affect horses, pigs, deer and man. It is found Worldwide, and within the UK, with its prevalence ever increasing. It is responsible for a 10-15% production loss in each infected animal, as it affects meat, milk and wool production, so is of huge economic consequence.

''Fasciola Hepatica'' has a definitive ruminant mammalian host and an intermediate molluscan host (indirect life cycle). Within Europe the intermediate host is almost exclusively the amphibious snail ''Galba truncatula'' (previously ''Lymnaea truncatulata''). The snail habitat is crucial to the survival of the parasite, so wet conditions are favourable to the development and spread of ''Fasciola hepatica''.

[[Image:Fasciola hepatica.jpg|400px|thumb|right|''Fasciola hepatica'' Adam Cuerden 2007, Wikimedia Commons]]

==Life Cycle==

Adult flukes in the bile ducts shed '''eggs''' directly into the bile, which then subsequently enter the intestine. Eggs are then passed out in the faeces of the mammalian host, where they develop and hatch releasing motile ciliated '''miracidia'''. These require 9-10 days at optimal temperatures, of around 22-26 degrees. The miracidium have a short life and must locate a suitable snail, the intermediate host, within approximately 3 hours if they are to be effective and continue the life cycle.

If successful, the miracidium will then develop into '''sporocysts''', then enter the '''redial stages''' to the final stages within the intermediate host, which is development into '''cercaria'''. These cercaria are then released from the snail, and attach to surfaces such as the tips of grass. Here they encyst and form '''metacercaria'''. This represents the infective stage of the lifecycle.

Development from miracidium into metacercariae takes around 6-7 weeks under favourable conditions, however, this period can be much longer in unfavourable conditions.

Upon ingestion by the final or definitive host from the grass, metacercariae excyst to present as immature flukes in the small intestine. These then migrate across the peritoneal cavity over a period of roughly one week, and invade the liver. Larvae continue to migrate within the hepatic parenchyma, becoming more destructive as they grow to a length of up to one centimetre. The young liver flukes migrate through the liver for around 6-8 weeks before entering the bile ducts where they mature to adults and begin to produce eggs. They may also migrate into the gall bladder, where they reach full sexual maturity.

The prepatent period of ''Fasciola hepatica'' is 10-12 weeks. In untreated sheep it may survive and continue to infect for many years. In cattle it is usually less than 1 year.

==Identification==

The egg is relatively large; around 140μm x 70μm. It is oval shaped, with a thin outer shell, and is browny-yellow.

The fully mature adult fluke is a dark brown colour, and around 3cm in length.

==Snail biology==
[[Image:Lymnaea truncatula.jpg|thumb|right|150px|''Lymnaea truncatula'' - Francisco Welter Schultes, Wikimedia Commons]]
=== ''Lymnaea truncatula'' ===
''Lympnea truncatula'' is around 5-10mm long. It has a distinctive brown-black shell, with 5-6 spirals present on the outer surface. The first spiral is approximately half the total length of the snail.

It feeds on green slime, and when this is present in abundance, they may multiply rapidly.

Most die in the British winter, due to the harsh, cold conditions, but they may survive in milder winters. Survivors will lay eggs in spring, which will hatch in June.

===Habitats===
''Lymnaea'' are found predominantly in muddy areas, but do not survive well in highly acidic soils. Habitats may be permanent; seen in dry summers or temporary; found in wet summers.

===Epidemiology===
Wet summers increase both the number of snail habitats and the hatching of fluke eggs, leading to many infected snails. These in turn shed many cercariae, which form a high density of metacercariae on herbage to increase the risk of fasciolosis. Conversely, in dry summers, fewer fluke eggs hatch and snails are restricted to their permanent habitats. Fewer snails become infected and cercariae and metacercariae numbers are low and confined to the areas where snails can survive. The risk of fasciolosis is therefore reduced.

In temperate areas, there are two superimposed epidemiological cycles, known as the summer and winter infections of the snail. On mainland Britain, the summer cycle predominates as a high proportion of snails perish during the winter, but very occasionally, weather sequences allow the winter cycle to affect the pattern of disease. On the west coast of Ireland, the winter cycle of events determines the timing of clinical outbreaks.

==== Summer infection of the snail ====
The fluke eggs passed in spring will hatch in June. This coincides with the hatching of the snail. The miracidia will then infect the newly hatched snails, mature and then multiply within the snail hepatopancreas during the summer months.

The cercariae are shed from late August onwards. The metacercariae develop and are ingested by a host; the sheep for example. The immature flukes then migrate through the liver, causing acute disease between the months of September and November, or chronic disease from January onwards.

====Winter infection of the snail====
In this case the fluke eggs are passed in the late summmer, which then infect the snails. Environmental conditions play a vital role in the success of the fluke development. Temperatures below 10 degrees will see the development being haltered, and the flukes will remain trapped in the hibernating snails throughout the winter. Development will then resume when temperatures rise above 10 degrees. The cercariae are then shed from July, and disease may be seen from August onwards.

==Pathogenesis==

The severity of the infection, [[Fasciolosis]], is mainly dependent on the number of metacercariae ingested. The pathogenesis is often described as two-fold. The first stage occurring when the parasite migrates through the liver parenchyma, causing liver damage and haemorrhage. The second phase occurs when the parasite is in the bile ducts, and damage is a result of the haematophagic activity of the adult flukes.

==Test yourself with the Trematodes Flashcards==

[[Trematodes_Flashcards|Trematodes Flashcards]]

==Literature Search==
[[File:CABI logo.jpg|left|90px]]

Use these links to find recent scientific publications via CAB Abstracts (log in required unless accessing from a subscribing organisation).
 
[http://www.cabdirect.org/search.html?rowId=1&options1=AND&q1=%22Fasciola+hepatica%22&occuring1=title&rowId=2&options2=AND&q2=&occuring2=freetext&rowId=3&options3=AND&q3=&occuring3=freetext&publishedstart=2000&publishedend=yyyy&calendarInput=yyyy-mm-dd&la=any&it=any&show=all&x=46&y=7 ''Fasciola hepatica'' publications since 2000]

==References==

Taylor, M.A, Coop, R.L., Wall,R.L. (2007) '''Veterinary Parasitology''' ''Blackwell Publishing''

G.L. Pritchard et al., Emergence of fasciolosis in cattle in East Anglia, ''The Veterinary Record'', November 5, 2005.

[[Category:Trematodes]]

[[Category:Liver Trematodes]]

[[Category:Cattle]][[Category:Sheep]][[Category:Horse Parasites]][[Category:Pig]][[Category:Goat]]

[[Category:Expert_Review]]

Anthelmintic Drugs

2010-11-23T20:08:29Z

Cryptic: capabel = capable

{{review}}
{{toplink
|linkpage =WikiDrugs
|linktext =WikiDrugs
|sublink1 = Antiparasitic Drugs
|subtext1 = Antiparasitic Drugs
|pagetype = Drugs
}}

[[Image: fasciola_hepatica.jpg|thumb|right|250px|Fasciola hepatica - the liver fluke]]

These chemotherapeutic agents are selectively toxic pharmaceutical compounds that aid in parasite control without damage to the host. They are selectively toxic as they have greater affinity to the parasite target site than a similar site in the host. The drugs here are all used for activity against the different classes of helminths but some also have activity against ectoparasites and are known as '''endectocides'''.

These drugs as usually formulated so that they can be administered orally (in drench, tablet or in feed form), by injection or percutaneously (as a pour on). In cattle production intraruminal delivary systems or '''rumen boluses''' have been developed. They are capable of delivering the anthelmintic for periods of over 90 days. There are two types of delivery system. The '''sustained release''' boluses work via a diffusion gradient, osmotic pump or mechanical device and emit the anthelmintic at a constant rate. The '''pulse release''' boluses emit therapeutic doses every three weeks. Oxfenbendazole is currently the only drug that has been formulated in this way.

On the following pages we shall discuss all the main classes of anthelmintics that are on the market, how they work and which classes of parasites they are active against. Some of the products are labelled with a coding system in the UK. This is in attempt to make it easier for farmers and vets to choose which group of drug would be best to use. This is because each group has a similar mode of action and so hopefully the coding system will help avoid resistance problems.

* [[Levamisole]]
* [[Morantel]]
* [[Macrocyclic Lactones]] - Avermectins and Milbemycins
* [[Cyclo-octodepsipeptides - CODPs]]
* [[Benzimidazoles]]
* [[Salicylanilide Flukicides]]
* [[Praziquantel]]
* '''Arsenicals''' - '''Thiacetarsamide''' has been used to treat the adult heartworm but is very toxic. It is hepatotoxic, nephrotoxic and will cause necrosis if not injected directly into the vein. '''Melarsomine''' is a new drug that has just become available.

==Literature Search==
[[File:CABI logo.jpg|left|90px]]

Use these links to find recent scientific publications via CAB Abstracts (log in required unless accessing from a subscribing organisation).
 
[http://www.cabi.org/cabdirect/FullTextPDF/2007/20073166514.pdf '''Beyond anthelmintics: parasite management in small ruminants.''' Snyder, J. H.; The North American Veterinary Conference, Gainesville, USA, Large animal. Proceedings of the North American Veterinary Conference, Volume 21, Orlando, Florida, USA, 2007, 2007, pp 273-279 - '''Full Text Article''']