WikiVet English - User contributions [en]

Laboratory mice strain information

2010-09-09T11:03:10Z

Kerstin: /* 129 mice: */

[[Category:Laboratory_animals]]
=Common Inbred mice strains and their pathology=

==C57BL/6 (B6) mice:==
Gold standard background strain for GEM's, genome of this strain has been fully sequenced. B6 mice were initially bred for their longevity. Their melanism is manifested by their coat colour. melanin pigment in heart valves, splenic capsule and meninges.

'''Spontaneous diseases:'''
Hydrocephalus, hippocampal neurodegeneration, microphtalmia, anophtalmia, age-related cochlear degeneration (hearing loss), malocclusion and pulmonary proteinosis.

'''Common neoplasms:'''
Lymphoma (especially B-cell), haemangiosarcoma, and pituitary adenoma (especially prolactin-secreting cells)

==BALB/c mice:==
Albinos. Mature males are rather pugilistic.

'''Spontaneous diseases:'''
Dystrophic epicardial mineralisation of the right ventricular free wall, myocardial degeneration, auricular thrombosis, corneal opacities, hypocallosity (corpus callosus hypoplasia or even aplasia), age-related hearing loss.

BALB mice are markedly ressistant to amyloidosis.

'''Common neoplasms:'''
Lung adenomas, lymphoma, Harderian gland tumours, myoepitheliomas of salivary, preputial, and other exocrine glands and adrenal adenomas.

==C3H/He mice:==
Agouti (brown) mice that are blind due to ''rd1'' mutation in the ''Pde6b'' gene.

'''Spontaneous diseases:'''
Focal myocardial and skeletal mineralisation and myocardial degeneration, alopecia areata (females more than males).

'''Common neoplasms:'''
They are more susceptible to exogenous murine mammary tumours virus (MMTV)-induced mammary tumours and develop a relatively high incidence of mammary neoplasia later in life due to endogenous MMTV.
Other common tumours include hepatocellular tumours.

==129 mice:==
Represent the most frequent source of embryonic stem cells (ES cells). The 129 mouse is not a single strain, and in fact the "129" is represented by 16 recognised strains and substrains.

'''Spontaneous diseases:'''
Hypocallosity, megaoesophagus, pulmonary proteinosis and epithelial hyalinosis, blepharitis, and conjunctivitis.

'''Common neoplasms:'''
Testicular teratomas, lung tumours, Harderian gland tumours, ovarian tumours, and haemangiosarcomas.

==FVB/N mice:==
Inbred swiss mice, they are blind due to homozygosity of ''rd1'' allele (''Pde6b'' gene).

'''Spontaneous diseases:'''
Seizures, mammary hyperplasia

'''Common neoplasms:'''
Tumours of the lung, pituitary gland, Harderian gland, and liver. Also lymphomas and pheochromocytomas.

== References==
*{{citation|initiallast = Brayton|initialfirst = C|2last = Justice|2first = M|finallast = Montgomery|lastfirst = C.A.|year = 2001|title = Evaluating Mutant Mice: Anatomic Pathology|pub = Vet Pathol 38: 1-9}}

*{{citation|initiallast = Percy|initialfirst = D.H|2last = and Barthold|2first = S.W|finallast = |year = 2007|title = Pathology of laboratory rodents and rabbits|pub = Blackwell Publishing. pp. 3-123}}

* http://www.informatics.jax.org/greenbook/index.shtml
[[Category:WikiPath]][[Category:WikiPath]][[Category:Rodents]]

Mice (Laboratory) - Pathology

2010-08-31T10:03:22Z

Kerstin: /* References */

{{review}}
{{toplink
|linkpage =Laboratory Animal Pathology - Pathology
|linktext =Laboratory Animal Pathology
|maplink = Laboratory Animal Pathology (Content Map) - Pathology
|pagetype =Pathology
}}
[[Image:White_mouse.jpg|200px|thumb|right|'''White Mice''' WikiCommons]]
==Anatomic features==
The laboratory mouse has several unique characteristics, and there are vast differences in normal anatomy, physiology, and behaviour among different strains of mice, many of which represent abnormalities arising from homozygosity of recessive or mutant traits in inbred mice.

The '''dental formula''' is 2(I 1/1, M 3/3) = 16. The incisors are open-rooted and grow continuously.

The '''stomach''' is divided into a proximal nonglandular portion and a distal glandular portion.

The left '''lung''' consists of one lobe, while the right lung consists of four lobes.

Mice have 3 pectoral and 2 inguinal pairs of '''mammary glands''', with mammary tissue enveloping much of the subcutis, including the neck. Mammary tissue can be found immediately adjacent to to salivary glands.

The mouse has the narrowest thermoneutral zone of any mammal thus far measured. A mouse responds to decreases in ambient temperature by nonshivering thermogenesis, and to increases in ambient temperature by decreasing metabolic rate and increasing vascularization of the ears. Nonshivering thermogenesis can produce a threefold increase in basal metabolic rate, and for the most part occurs in '''brown fat'''. The highest concentration of brown fat is found in the subcutaneous tissues between the scapulae.

The '''brain and spinal cord''' are larger in mature male mice compared to females.

The zona reticularis of the '''adrenal cortex''' is not discernible from the zona fasciculata. A unique feature of the mouse adrenal is the X zone of the cortex, which surrounds the medulla. The X zone is composed of basophilic cells but when males reach sexual maturity and females undergo their first pregnancy, the X zone disappears.

'''Melanosis''' occurs in several organs, including the anteroventral meninges of the olfactory bulbs, optic nerves, parathyroid glands, heart valves, and spleens of melanotic mouse strains, such as B6 mice.

==Strain Information==
Most laboratory mice have contributions from both Mus musculus musculus and Mus musculus domesticus. There is evidence that smaller contributions also may have come from Mus musculus molossinus and Mus musculus castaneus. Therefore, they should not be referred to by species name, but rather as laboratory mice or by use of a specific strain or stock name. (In addition, some recently developed laboratory mouse strains are derived wholly from other Mus species or other subspecies, such as M. spretus). The laboratory mouse genome, including its retroelements, is a mosaic and an artificial creation, and there is no true "wildtype" laboratory mouse.
There are over 450 inbred strains that have arisen during the last century but the great majority of biomedical resaerch, including genomic research, is based on a relatively few mouse strains, including C57BL/6, BALB/c, C3H/He, 129, FVB, and outbred Swiss stocks.

'''For more information on specific strains and the pathology associated with them, click [[Laboratory mice strain information|here]]

==Genetically Engineered Mice==
===Terminology===
Genetically engineered mice have induced mutations, including transgenes, targeted mutations (knockouts or knockins), and retroviral, proviral, or chemically-induced mutations.

Transgenic mice carry a segment of foreign DNA incorporated into their genome via non-homologous recombination (e.g., pronuclear microinjection), infection with a retroviral vector, or homologous insertion.

Targeted mutant mice are produced by first inducing gene disruptions, replacements, or duplications into embryonic stem (ES) cells via homologous recombination between the exogenous (targeting) DNA and the endogenous (target) gene. The genetically-modified ES cells are then microinjected into host embryos at the eight-cell blastocyst stage. These embryos are transferred to pseudopregnant host females, which then bear chimeric progeny. The chimeric progeny carrying the targeted mutation in their germ line are then bred to establish a line. If the newly established line has a disrupted or deleted gene, it is called a knockout; if it has a new or duplicated gene, it is called a knockin.

Mice with chemically-induced mutations are produced by using a variety of chemicals. One popular chemical mutagen, ethylnitrosourea (ENU), is used to induce point mutations. ENU mutagenesis involves exposing male mice to ENU and then mating the treated males to untreated females. The resultant progeny, many of which carry point mutations, are screened for phenotypes of interest.

===Applications===
Genetically engineered mice are useful for elucidating basic biological processes, studying relationships between gene mutations and disease phenotypes, and modeling human disease. Research applications are included on strain data sheets in the JAX® Mice Database. The applications are compiled using a number of information sources (please refer to Mouse Information Resources), but they are not all-inclusive: rapidly advancing biomedical research continually uncovers new applications and uses for genetically engineered and mutant mice strains.

Some genetically engineered and mutant mice strains have a mutation associated with a specific human disease. If the gene or mutation is orthologous to that in humans and causes the same disease in humans, the strain is designated as a model of the human disease. Manifestation of the genetic mutation (phenotypic expression) may differ between humans and mice. Investigators are strongly encouraged to research recommended mouse models to be sure they are appropriate for their research.

== References==
*{{citation|initiallast = Percy|initialfirst = D.H|2last = and Barthold|2first = S.W|finallast = |year = 2007|title = Pathology of laboratory rodents and rabbits|pub = Blackwell Publishing. pp. 3-123}}

*http://jaxmice.jax.org/type/gemm/index.html

Mice (Laboratory) - Pathology

2010-08-25T14:24:21Z

Kerstin:

{{review}}
{{toplink
|linkpage =Laboratory Animal Pathology - Pathology
|linktext =Laboratory Animal Pathology
|maplink = Laboratory Animal Pathology (Content Map) - Pathology
|pagetype =Pathology
}}
<br>
==[[Anatomic features]]==

==[[Laboratory mice strain information|Strain Information]]==

==[[Genetically Engineered Mice]]==

Mice (Laboratory) - Pathology

2010-08-25T14:21:38Z

Kerstin: /* Genetically Engineered Mice */

{{review}}
{{toplink
|linkpage =Laboratory Animal Pathology - Pathology
|linktext =Laboratory Animal Pathology
|maplink = Laboratory Animal Pathology (Content Map) - Pathology
|pagetype =Pathology
}}
<br>
==[[Anatomic features]]==

==[[Laboratory mice strain information|Strain Information]]==

==[[Genetically Engineered Mice]]==
===Terminology===

'''Definitions:'''
Genetically engineered mice have induced mutations, including transgenes, targeted mutations (knockouts or knockins), and retroviral, proviral, or chemically-induced mutations.

Transgenic mice carry a segment of foreign DNA incorporated into their genome via non-homologous recombination (e.g., pronuclear microinjection), infection with a retroviral vector, or homologous insertion.

Targeted mutant mice are produced by first inducing gene disruptions, replacements, or duplications into embryonic stem (ES) cells via homologous recombination between the exogenous (targeting) DNA and the endogenous (target) gene. The genetically-modified ES cells are then microinjected into host embryos at the eight-cell blastocyst stage. These embryos are transferred to pseudopregnant host females, which then bear chimeric progeny. The chimeric progeny carrying the targeted mutation in their germ line are then bred to establish a line. If the newly established line has a disrupted or deleted gene, it is called a knockout; if it has a new or duplicated gene, it is called a knockin.

Mice with chemically-induced mutations are produced by using a variety of chemicals. One popular chemical mutagen, ethylnitrosourea (ENU), is used to induce point mutations. ENU mutagenesis involves exposing male mice to ENU and then mating the treated males to untreated females. The resultant progeny, many of which carry point mutations, are screened for phenotypes of interest.

===Applications===

Genetically engineered mice are useful for elucidating basic biological processes, studying relationships between gene mutations and disease phenotypes, and modeling human disease. Research applications are included on strain data sheets in the JAX® Mice Database. The applications are compiled using a number of information sources (please refer to Mouse Information Resources), but they are not all-inclusive: rapidly advancing biomedical research continually uncovers new applications and uses for genetically engineered and mutant mice strains.

Some genetically engineered and mutant mice strains have a mutation associated with a specific human disease. If the gene or mutation is orthologous to that in humans and causes the same disease in humans, the strain is designated as a model of the human disease. Manifestation of the genetic mutation (phenotypic expression) may differ between humans and mice. Investigators are strongly encouraged to research recommended mouse models to be sure they are appropriate for their research.

===External link===
http://jaxmice.jax.org/type/gemm/index.html

Mice (Laboratory) - Pathology

2010-08-25T14:17:21Z

Kerstin: /* Genetically Engineered Mice */

{{review}}
{{toplink
|linkpage =Laboratory Animal Pathology - Pathology
|linktext =Laboratory Animal Pathology
|maplink = Laboratory Animal Pathology (Content Map) - Pathology
|pagetype =Pathology
}}
<br>
==[[Anatomic features]]==

==[[Laboratory mice strain information|Strain Information]]==

==[[Genetically Engineered Mice]]==

===Terminology===

'''Definitions:'''
Genetically engineered mice have induced mutations, including transgenes, targeted mutations (knockouts or knockins), and retroviral, proviral, or chemically-induced mutations.

Transgenic mice carry a segment of foreign DNA incorporated into their genome via non-homologous recombination (e.g., pronuclear microinjection), infection with a retroviral vector, or homologous insertion.

Targeted mutant mice are produced by first inducing gene disruptions, replacements, or duplications into embryonic stem (ES) cells via homologous recombination between the exogenous (targeting) DNA and the endogenous (target) gene. The genetically-modified ES cells are then microinjected into host embryos at the eight-cell blastocyst stage. These embryos are transferred to pseudopregnant host females, which then bear chimeric progeny. The chimeric progeny carrying the targeted mutation in their germ line are then bred to establish a line. If the newly established line has a disrupted or deleted gene, it is called a knockout; if it has a new or duplicated gene, it is called a knockin.

Mice with chemically-induced mutations are produced by using a variety of chemicals. One popular chemical mutagen, ethylnitrosourea (ENU), is used to induce point mutations. ENU mutagenesis involves exposing male mice to ENU and then mating the treated males to untreated females. The resultant progeny, many of which carry point mutations, are screened for phenotypes of interest.

===Applications===

Genetically engineered mice are useful for elucidating basic biological processes, studying relationships between gene mutations and disease phenotypes, and modeling human disease. Research applications are included on strain data sheets in the JAX® Mice Database. The applications are compiled using a number of information sources (please refer to Mouse Information Resources), but they are not all-inclusive: rapidly advancing biomedical research continually uncovers new applications and uses for genetically engineered and mutant mice strains.

Some genetically engineered and mutant mice strains have a mutation associated with a specific human disease. If the gene or mutation is orthologous to that in humans and causes the same disease in humans, the strain is designated as a model of the human disease. Manifestation of the genetic mutation (phenotypic expression) may differ between humans and mice. Investigators are strongly encouraged to research recommended mouse models to be sure they are appropriate for their research.

http://jaxmice.jax.org/type/gemm/index.html

Laboratory mice strain information

2010-08-25T14:03:19Z

Kerstin:

[[Category:Laboratory_animals]]
Most laboratory mice have contributions from both Mus musculus musculus and Mus musculus domesticus. There is evidence that smaller contributions also may have come from Mus musculus molossinus and Mus musculus castaneus. Therefore, they should not be referred to by species name, but rather as laboratory mice or by use of a specific strain or stock name. (In addition, some recently developed laboratory mouse strains are derived wholly from other Mus species or other subspecies, such as M. spretus). The laboratory mouse genome, including its retroelements, is a mosaic and an artificial creation, and there is no true "wildtype" laboratory mouse.
There are over 450 inbred strains that have arisen during the last century but the great majority of biomedical resaerch, including genomic research, is based on a relatively few mouse strains, including C57BL/6, BALB/c, C3H/He, 129, FVB, and outbred Swiss stocks.

=Common Inbred mice strains and their pathology=

==C57BL/6 (B6) mice:==
Gold standard background strain for GEM's, genome of this strain has been fully sequenced. B6 mice were initially bred for their longevity. Their melanism is manifested by their coat colour. melanin pigment in heart valves, splenic capsule and meninges.

'''Spontaneous diseases:'''
Hydrocephalus, hippocampal neurodegeneration, microphtalmia, anophtalmia, age-related cochlear degeneration (hearing loss), malocclusion and pulmonary proteinosis.

'''Common neoplasms:'''
Lymphoma (especially B-cell), haemangiosarcoma, and pituitary adenoma (especially prolactin-secreting cells)

==BALB/c mice:==
Albinos. Mature males are rather pugilistic.

'''Spontaneous diseases:'''
Dystrophic epicardial mineralisation of the right ventricular free wall, myocardial degeneration, auricular thrombosis, corneal opacities, hypocallosity (corpus callosus hypoplasia or even aplasia), age-related hearing loss.

BALB mice are markedly ressistant to amyloidosis.

'''Common neoplasms:'''
Lung adenomas, lymphoma, Harderian gland tumours, myoepitheliomas of salivary, preputial, and other exocrine glands and adrenal adenomas.

==C3H/He mice:==
Agouti (brown) mice that are blind due to ''rd1'' mutation in the ''Pde6b'' gene.

'''Spontaneous diseases:'''
Focal myocardial and skeletal mineralisation and myocardial degeneration, alopecia areata (females more than males).

'''Common neoplasms:'''
They are more susceptible to exogenous murine mammary tumours virus (MMTV)-induced mammary tumours and develop a relatively high incidence of mammary neoplasia later in life due to endogenous MMTV.
Other common tumours include hepatocellular tumours.

==129 mice:==
Represent the most frequent source of embryonic stem cells (ES cells). The 129 mouse is not a single strain, and in fact the "129" is represented by 16 recognised strains and substrains.

'''Spontaneous diseases:'''
Hypercallosity, megaoesophagus, pulmonary proteinosis and epithelial hyalinosis, blepharitis, and conjunctivitis.

'''Common neoplasms:'''
Testicular teratomas, lung tumours, Harderian gland tumours, ovarian tumours, and haemangiosarcomas.

==FVB/N mice:==
Inbred swiss mice, they are blind due to homozygosity of ''rd1'' allele (''Pde6b'' gene).

'''Spontaneous diseases:'''
Seizures, mammary hyperplasia

'''Common neoplasms:'''
Tumours of the lung, pituitary gland, Harderian gland, and liver. Also lymphomas and pheochromocytomas.

== References==
*{{citation|initiallast = Brayton|initialfirst = C|2last = Justice|2first = M|finallast = Montgomery|lastfirst = C.A.|year = 2001|title = Evaluating Mutant Mice: Anatomic Pathology|pub = Vet Pathol 38: 1-9}}

*{{citation|initiallast = Percy|initialfirst = D.H|2last = and Barthold|2first = S.W|finallast = |year = 2007|title = Pathology of laboratory rodents and rabbits|pub = Blackwell Publishing. pp. 3-123}}

* http://www.informatics.jax.org/greenbook/index.shtml
[[Category:WikiPath]][[Category:WikiPath]][[Category:Rodents]]

Laboratory mice strain information

2010-08-25T13:58:07Z

Kerstin:

[[Category:Laboratory_animals]]
Most laboratory mice have contributions from both Mus musculus musculus and Mus musculus domesticus. There is evidence that smaller contributions also may have come from Mus musculus molossinus and Mus musculus castaneus. Therefore, they should not be referred to by species name, but rather as laboratory mice or by use of a specific strain or stock name. (In addition, some recently developed laboratory mouse strains are derived wholly from other Mus species or other subspecies, such as M. spretus). The laboratory mouse genome, including its retroelements, is a mosaic and an artificial creation, and there is no true "wildtype" laboratory mouse.
There are over 450 inbred strains that have arisen during the last century but the great majority of biomedical resaerch, including genomic research, is based on a relatively few mouse strains, including C57BL/6, BALB/c, C3H/He, 129, FVB, and outbred Swiss stocks.

=Common Inbred mice strains and their pathology=

==C57BL/6 (B6) mice:==
Gold standard background strain for GEM's, genome of this strain has been fully sequenced. B6 mice were initially bred for their longevity. Their melanism is manifested by their coat colour. melanin pigment in heart valves, splenic capsule and meninges.

'''Spontaneous diseases:'''
Hydrocephalus, hippocampal neurodegeneration, microphtalmia, anophtalmia, age-related cochlear degeneration (hearing loss), malocclusion and pulmonary proteinosis.

'''Common neoplasms:'''
Lymphoma (especially B-cell), haemangiosarcoma, and pituitary adenoma (especially prolactin-secreting cells)

==BALB/c mice:==
Albinos. Mature males are rather pugilistic.

'''Spontaneous diseases:'''
Dystrophic epicardial mineralisation of the right ventricular free wall, myocardial degeneration, auricular thrombosis, corneal opacities, hypocallosity (corpus callosus hypoplasia or even aplasia), age-related hearing loss.

BALB mice are markedly ressistant to amyloidosis.

'''Common neoplasms:'''
Lung adenomas, lymphoma, Harderian gland tumours, myoepitheliomas of salivary, preputial, and other exocrine glands and adrenal adenomas.

==C3H/He mice:==
Agouti (brown) mice that are blind due to ''rd1'' mutation in the ''Pdeb'' gene.

'''Spontaneous diseases:'''
Focal myocardial and skeletal mineralisation and myocardial degeneration, alopecia areata (females more than males).

'''Common neoplasms:'''
They are more susceptible to exogenous murine mammary tumours virus (MMTV)-induced mammary tumours and develop a relatively high incidence of mammary neoplasia later in life due to endogenous MMTV.
Other common tumours include hepatocellular tumours.

==129 mice:==
Represent the most frequent source of embryonic stem cells (ES cells). The 129 mouse is not a single strain, and in fact the "129" is represented by 16 recognised strains and substrains.

'''Spontaneous diseases:'''
Hypercallosity, megaoesophagus, pulmonary proteinosis and epithelial hyalinosis, blepharitis, and conjunctivitis.

'''Common neoplasms:'''
Testicular teratomas, lung tumours, Harderian gland tumours, ovarian tumours, and haemangiosarcomas.

==FVB/N mice:==

'''Spontaneous diseases:'''

'''Common neoplasms:'''

== References==
*{{citation|initiallast = Brayton|initialfirst = C|2last = Justice|2first = M|finallast = Montgomery|lastfirst = C.A.|year = 2001|title = Evaluating Mutant Mice: Anatomic Pathology|pub = Vet Pathol 38: 1-9}}

*{{citation|initiallast = Percy|initialfirst = D.H|2last = and Barthold|2first = S.W|finallast = |year = 2007|title = Pathology of laboratory rodents and rabbits|pub = Blackwell Publishing. pp. 3-123}}

* http://www.informatics.jax.org/greenbook/index.shtml
[[Category:WikiPath]][[Category:WikiPath]][[Category:Rodents]]

Laboratory mice strain information

2010-08-25T13:41:14Z

Kerstin:

[[Category:Laboratory_animals]]
Most laboratory mice have contributions from both Mus musculus musculus and Mus musculus domesticus. There is evidence that smaller contributions also may have come from Mus musculus molossinus and Mus musculus castaneus. Therefore, they should not be referred to by species name, but rather as laboratory mice or by use of a specific strain or stock name. (In addition, some recently developed laboratory mouse strains are derived wholly from other Mus species or other subspecies, such as M. spretus). The laboratory mouse genome, including its retroelements, is a mosaic and an artificial creation, and there is no true "wildtype" laboratory mouse.
There are over 450 inbred strains that have arisen during the last century but the great majority of biomedical resaerch, including genomic research, is based on a relatively few mouse strains, including C57BL/6, BALB/c, C3H/He, 129, FVB, and outbred Swiss stocks.

=Common Inbred mice strains and their pathology=

==C57BL/6 (B6) mice:==
Gold standard background strain for GEM's, genome of this strain has been fully sequenced. B6 mice were initially bred for their longevity. Their melanism is manifested by their coat colour. melanin pigment in heart valves, splenic capsule and meninges.

'''Spontaneous diseases:'''
Hydrocephalus, hippocampal neurodegeneration, microphtalmia, anophtalmia, age-related cochlear degeneration (hearing loss), malocclusion and pulmonary proteinosis.

'''Common neoplasms:'''
Lymphoma (especially B-cell), haemangiosarcoma, and pituitary adenoma (especially prolactin-secreting cells)

==BALB/c mice:==
Albinos. Mature males are rather pugilistic.

'''Spontaneous diseases:'''
Dystrophic epicardial mineralisation of the right ventricular free wall, myocardial degeneration, auricular thrombosis, corneal opacities, hypocallosity (corpus callosus hypoplasia or even aplasia), age-related hearing loss.

BALB mice are markedly ressistant to amyloidosis.

'''Common neoplasms:'''
Lung adenomas, lymphoma, Harderian gland tumours, myoepitheliomas of salivary, preputial, and other exocrine glands and adrenal adenomas.

==C3H/He mice:==
Agouti (brown) mice that are blind due to ''rd1'' mutation in the ''Pdeb'' gene.

'''Spontaneous diseases:'''
Focal myocardial and skeletal mineralisation and myocardial degeneration, alopecia areata (females more than males).

'''Common neoplasms:'''
They are more susceptible to exogenous murine mammary tumours virus (MMTV)-induced mammary tumours and develop a relatively high incidence of mammary neoplasia later in life due to endogenous MMTV.
Other common tumours include hepatocellular tumours.

==129 mice:==
Represent the most frequent source of embryonic stem cells (ES cells). The 129 mouse is not a single strain, and in fact the "129" is represented by 16 recognised strains and substrains.

'''Spontaneous diseases:'''

'''Common neoplasms:'''

==FVB/N mice:==

'''Spontaneous diseases:'''

'''Common neoplasms:'''

== References==
*{{citation|initiallast = Brayton|initialfirst = C|2last = Justice|2first = M|finallast = Montgomery|lastfirst = C.A.|year = 2001|title = Evaluating Mutant Mice: Anatomic Pathology|pub = Vet Pathol 38: 1-9}}

*{{citation|initiallast = Percy|initialfirst = D.H|2last = and Barthold|2first = S.W|finallast = |year = 2007|title = Pathology of laboratory rodents and rabbits|pub = Blackwell Publishing. pp. 3-123}}

* http://www.informatics.jax.org/greenbook/index.shtml
[[Category:WikiPath]][[Category:WikiPath]][[Category:Rodents]]

Laboratory mice strain information

2010-08-25T13:15:32Z

Kerstin:

[[Category:Laboratory_animals]]
Most laboratory mice have contributions from both Mus musculus musculus and Mus musculus domesticus. There is evidence that smaller contributions also may have come from Mus musculus molossinus and Mus musculus castaneus. Therefore, they should not be referred to by species name, but rather as laboratory mice or by use of a specific strain or stock name. (In addition, some recently developed laboratory mouse strains are derived wholly from other Mus species or other subspecies, such as M. spretus). The laboratory mouse genome, including its retroelements, is a mosaic and an artificial creation, and there is no true "wildtype" laboratory mouse.
There are over 450 inbred strains that have arisen during the last century but the great majority of biomedical resaerch, including genomic research, is based on a relatively few mouse strains, including C57BL/6, BALB/c, C3H/He, 129, FVB, and outbred Swiss stocks.

=Common Inbred mice strains and their pathology=

==C57BL/6 (B6) mice:==
Gold standard background strain for GEM's, genome of this strain has been fully sequenced. B6 mice were initially bred for their longevity. Their melanism is manifested by their coat colour. melanin pigment in heart valves, splenic capsule and meninges.

'''Spontaneous diseases:'''
Hydrocephalus, hippocampal neurodegeneration, microphtalmia, anophtalmia, age-related cochlear degeneration (hearing loss), malocclusion and pulmonary proteinosis.

'''Common neoplasms:'''
Lymphoma (especially B-cell), haemangiosarcoma, and pituitary adenoma (especially prolactin-secreting cells)

==BALB/c mice:==
Are albinos. Mature males are rather pugilistic.

'''Spontaneous diseases:'''
Dystrophic epicardial mineralisation of the right ventricular free wall, myocardial degeneration, auricular thrombosis, corneal opacities, hypocallosity (corpus callosus hypoplasia or even aplasia, age-related hearing loss.

BALB mice are markedly ressistant to amyloidosis

'''Common neoplasms:'''
Lung adenomas, lymphoma, Harderian gland tumours, myoepitheliomas of salivary, preputial, and other exocrine glands and adrenal adenomas.

==C3H/He mice:==

'''Spontaneous diseases:'''

'''Common neoplasms:'''

==129 mice:==

'''Spontaneous diseases:'''

'''Common neoplasms:'''

==FVB/N mice:==

'''Spontaneous diseases:'''

'''Common neoplasms:'''

== References==
*{{citation|initiallast = Brayton|initialfirst = C|2last = Justice|2first = M|finallast = Montgomery|lastfirst = C.A.|year = 2001|title = Evaluating Mutant Mice: Anatomic Pathology|pub = Vet Pathol 38: 1-9}}

*{{citation|initiallast = Percy|initialfirst = D.H|2last = and Barthold|2first = S.W|finallast = |year = 2007|title = Pathology of laboratory rodents and rabbits|pub = Blackwell Publishing. pp. 3-123}}

* http://www.informatics.jax.org/greenbook/index.shtml
[[Category:WikiPath]][[Category:WikiPath]][[Category:Rodents]]

Laboratory mice strain information

2010-08-25T13:00:43Z

Kerstin: /* C57BL/6 (B6) mice: */

Laboratory mice strain information

2010-08-25T12:55:53Z

Kerstin: /* References */

Mice (Laboratory) - Pathology

2010-08-24T14:02:40Z

Kerstin:

{{review}}
{{toplink
|linkpage =Laboratory Animal Pathology - Pathology
|linktext =Laboratory Animal Pathology
|maplink = Laboratory Animal Pathology (Content Map) - Pathology
|pagetype =Pathology
}}
<br>
==[[Anatomic features]]==

==[[Laboratory mice strain information|Strain Information]]==

==[[Genetically Engineered Mice]]==

Laboratory mice strain information

2010-08-24T13:54:42Z

Kerstin: /* Outbred Swiss mice: */

Laboratory mice strain information

2010-08-24T13:52:49Z

Kerstin:

Laboratory mice strain information

2010-06-01T11:31:19Z

Kerstin:

Laboratory mice strain information

2010-06-01T11:22:05Z

Kerstin: /* References */

Laboratory mice strain information

2010-06-01T10:52:49Z

Kerstin: /* References */

Laboratory mice strain information

2010-06-01T10:33:14Z

Kerstin:

Laboratory mice strain information

2010-06-01T10:24:43Z

Kerstin: