Anthelmintic Drugs - Revision history

Cryptic: capabel = capable

2010-11-23T20:08:29Z

capabel = capable

Bara at 19:40, 14 November 2010

2010-11-14T19:40:46Z

Amazonian at 21:34, 29 September 2009

2009-09-29T21:34:35Z

Amazonian: separated [levamisole and morantel] into [levamisole] and [morantel] as they do not belong to the same class of drugs

2009-09-29T21:20:41Z

separated [levamisole and morantel] into [levamisole] and [morantel] as they do not belong to the same class of drugs

Jtulloch at 14:40, 3 November 2008

2008-11-03T14:40:03Z

Jtulloch at 14:39, 3 November 2008

2008-11-03T14:39:43Z

Jtulloch at 14:29, 3 November 2008

2008-11-03T14:29:43Z

Jtulloch at 14:21, 3 November 2008

2008-11-03T14:21:32Z

Jtulloch at 14:02, 3 November 2008

2008-11-03T14:02:12Z

Jtulloch at 13:55, 3 November 2008

2008-11-03T13:55:20Z

@@ Line 12: / Line 12: @@
 These chemotherapeutic agents are selectively toxic pharmaceutical compounds that aid in parasite control without damage to the host. They are selectively toxic as they have greater affinity to the parasite target site than a similar site in the host. The drugs here are all used for activity against the different classes of helminths but some also have activity against ectoparasites and are known as '''endectocides'''.
-These drugs as usually formulated so that they can be administered orally (in drench, tablet or in feed form), by injection or percutaneously (as a pour on). In cattle production intraruminal delivary systems or '''rumen boluses''' have been developed. They are capabel of delivering the anthelmintic for periods of over 90 days. There are two types of delivery system. The '''sustained release''' boluses work via a diffusion gradient, osmotic pump or mechanical device and emit the anthelmintic at a constant rate. The '''pulse release''' boluses emit therapeutic doses every three weeks. Oxfenbendazole is currently the only drug that has been formulated in this way.
+These drugs as usually formulated so that they can be administered orally (in drench, tablet or in feed form), by injection or percutaneously (as a pour on). In cattle production intraruminal delivary systems or '''rumen boluses''' have been developed. They are capable of delivering the anthelmintic for periods of over 90 days. There are two types of delivery system. The '''sustained release''' boluses work via a diffusion gradient, osmotic pump or mechanical device and emit the anthelmintic at a constant rate. The '''pulse release''' boluses emit therapeutic doses every three weeks. Oxfenbendazole is currently the only drug that has been formulated in this way.
 On the following pages we shall discuss all the main classes of anthelmintics that are on the market, how they work and which classes of parasites they are active against. Some of the products are labelled with a coding system in the UK. This is in attempt to make it easier for farmers and vets to choose which group of drug would be best to use. This is because each group has a similar mode of action and so hopefully the coding system will help avoid resistance problems.

← Older revision		Revision as of 19:40, 14 November 2010
Line 26:		Line 26:
	* [[Praziquantel]]		* [[Praziquantel]]
	* '''Arsenicals''' - '''Thiacetarsamide''' has been used to treat the adult heartworm but is very toxic. It is hepatotoxic, nephrotoxic and will cause necrosis if not injected directly into the vein. '''Melarsomine''' is a new drug that has just become available.		* '''Arsenicals''' - '''Thiacetarsamide''' has been used to treat the adult heartworm but is very toxic. It is hepatotoxic, nephrotoxic and will cause necrosis if not injected directly into the vein. '''Melarsomine''' is a new drug that has just become available.
		+
		+	==Literature Search==
		+	[[File:CABI logo.jpg\|left\|90px]]
		+
		+
		+	Use these links to find recent scientific publications via CAB Abstracts (log in required unless accessing from a subscribing organisation).
		+	<br><br><br>
		+	[http://www.cabi.org/cabdirect/FullTextPDF/2007/20073166514.pdf '''Beyond anthelmintics: parasite management in small ruminants.''' Snyder, J. H.; The North American Veterinary Conference, Gainesville, USA, Large animal. Proceedings of the North American Veterinary Conference, Volume 21, Orlando, Florida, USA, 2007, 2007, pp 273-279 - '''Full Text Article''']

@@ Line 19: / Line 19: @@
 * [[Levamisole]]
-* [[Levamisole and Morantel]]
+* [[Morantel]]
 * [[Macrocyclic Lactones]] - Avermectins and Milbemycins
 * [[Cyclo-octodepsipeptides - CODPs]]

← Older revision		Revision as of 21:20, 29 September 2009
Line 17:		Line 17:


		+
		+	* [[Levamisole]]
	* [[Levamisole and Morantel]]		* [[Levamisole and Morantel]]
	* [[Macrocyclic Lactones]] - Avermectins and Milbemycins		* [[Macrocyclic Lactones]] - Avermectins and Milbemycins

@@ Line 23: / Line 23: @@
 * [[Salicylanilide Flukicides]]
 * [[Praziquantel]]
-* Arsenicals - '''Thiacetarsamide''' has been used to treat the adult heartworm but is very toxic. It is hepatotoxic, nephrotoxic and will cause necrosis if not injected directly into the vein. '''Melarsomine''' is a new drug that has just become available.
+* '''Arsenicals''' - '''Thiacetarsamide''' has been used to treat the adult heartworm but is very toxic. It is hepatotoxic, nephrotoxic and will cause necrosis if not injected directly into the vein. '''Melarsomine''' is a new drug that has just become available.

@@ Line 1: / Line 1: @@
-{{unfinished}}
+{{review}}
 {{toplink
 |linkpage =WikiDrugs
@@ Line 23: / Line 23: @@
 * [[Salicylanilide Flukicides]]
 * [[Praziquantel]]

← Older revision		Revision as of 14:29, 3 November 2008
Line 22:		Line 22:
	* [[Benzimidazoles]]		* [[Benzimidazoles]]
	* [[Salicylanilide Flukicides]]		* [[Salicylanilide Flukicides]]
		+	* [[Praziquantel]]

← Older revision		Revision as of 14:21, 3 November 2008
Line 21:		Line 21:
	* [[Cyclo-octodepsipeptides - CODPs]]		* [[Cyclo-octodepsipeptides - CODPs]]
	* [[Benzimidazoles]]		* [[Benzimidazoles]]
		+	* [[Salicylanilide Flukicides]]

← Older revision		Revision as of 14:02, 3 November 2008
Line 20:		Line 20:
	* [[Macrocyclic Lactones]] - Avermectins and Milbemycins		* [[Macrocyclic Lactones]] - Avermectins and Milbemycins
	* [[Cyclo-octodepsipeptides - CODPs]]		* [[Cyclo-octodepsipeptides - CODPs]]
		+	* [[Benzimidazoles]]

← Older revision		Revision as of 13:55, 3 November 2008
Line 19:		Line 19:
	* [[Levamisole and Morantel]]		* [[Levamisole and Morantel]]
	* [[Macrocyclic Lactones]] - Avermectins and Milbemycins		* [[Macrocyclic Lactones]] - Avermectins and Milbemycins
		+	* [[Cyclo-octodepsipeptides - CODPs]]