Anticoagulant Rodenticide Toxicity - Revision history

TestStudent at 13:59, 6 September 2015

2015-09-06T13:59:13Z

Bara at 14:05, 15 October 2013

2013-10-15T14:05:10Z

Bara at 22:56, 10 October 2011

2011-10-10T22:56:40Z

Bara: /* References */

2011-02-24T16:00:50Z

References

Bara: /* References */

2010-12-20T15:36:34Z

References

Bara: /* References */

2010-12-16T16:53:20Z

References

Bara: Text replace - "Category:Gastric Pathology - Dog" to "Category:Gastric Diseases - Dog"

2010-12-16T15:20:54Z

Text replace - "Category:Gastric Pathology - Dog" to "Category:Gastric Diseases - Dog"

Bara at 16:13, 14 December 2010

2010-12-14T16:13:47Z

Bara: /* Laboratory Tests */

2010-12-14T16:12:33Z

Laboratory Tests

Suzannah.stacey at 18:17, 18 October 2010

2010-10-18T18:17:16Z

@@ Line 58: / Line 58: @@
 {{Learning
 |literature search = [http://www.cabdirect.org/search.html?q=title:(Anticoagulant+)+AND+title:(Rodenticide)+AND+title:(Toxicity) Anticoagulant rodenticide toxicity publications]
 |flashcards = [[Small Animal Emergency and Critical Care Medicine Q&A 22]]

← Older revision		Revision as of 14:05, 15 October 2013
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	[[Category:Lymphoreticular and Haematopoietic Diseases - Dog]][[Category:Lymphoreticular and Haematopoietic Diseases - Cat]]		[[Category:Lymphoreticular and Haematopoietic Diseases - Dog]][[Category:Lymphoreticular and Haematopoietic Diseases - Cat]]
	[[Category:Toxicology]]		[[Category:Toxicology]]
		+	[[Category:Cardiology Section]]

@@ Line 57: / Line 57: @@
 The prognosis for anticoagulant rodenticide toxicity is guarded, but improves if the patient survives the first 48 hours of acute coagulopathy<sup>7</sup>.
-==Literature Search==
+{{Learning
-[[File:CABI logo.jpg|left|90px]]
+|literature search = [http://www.cabdirect.org/search.html?q=title:(Anticoagulant+)+AND+title:(Rodenticide)+AND+title:(Toxicity) Anticoagulant rodenticide toxicity publications]
+|flashcards = [[Small Animal Emergency and Critical Care Medicine Q&A 22]]
+}}
 ==Links==

← Older revision		Revision as of 16:00, 24 February 2011
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	[[Category:Stomach_and_Abomasum_-_Pathology]] [[Category:Gastric Diseases - Dog]] [[Category:Gastric Diseases - Cat]][[Category:Coagulation Defects\|Z]]		[[Category:Stomach_and_Abomasum_-_Pathology]] [[Category:Gastric Diseases - Dog]] [[Category:Gastric Diseases - Cat]][[Category:Coagulation Defects\|Z]]
	[[Category:Lymphoreticular and Haematopoietic Diseases - Dog]][[Category:Lymphoreticular and Haematopoietic Diseases - Cat]]		[[Category:Lymphoreticular and Haematopoietic Diseases - Dog]][[Category:Lymphoreticular and Haematopoietic Diseases - Cat]]
		+	[[Category:Toxicology]]

← Older revision		Revision as of 15:36, 20 December 2010
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−	[[Category:Stomach_and_Abomasum_-_Pathology]] [[Category:Gastric Diseases - Dog]] [[Category:Cat]][[Category:Coagulation Defects\|Z]]	+	[[Category:Stomach_and_Abomasum_-_Pathology]] [[Category:Gastric Diseases - Dog]] [[Category:Gastric Diseases - Cat]][[Category:Coagulation Defects\|Z]]
−	[[Category:Lymphoreticular and Haematopoietic Diseases - Dog]]	+	[[Category:Lymphoreticular and Haematopoietic Diseases - Dog]][[Category:Lymphoreticular and Haematopoietic Diseases - Cat]]

← Older revision		Revision as of 16:53, 16 December 2010
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	[[Category:Stomach_and_Abomasum_-_Pathology]] [[Category:Gastric Diseases - Dog]] [[Category:Cat]][[Category:Coagulation Defects\|Z]]		[[Category:Stomach_and_Abomasum_-_Pathology]] [[Category:Gastric Diseases - Dog]] [[Category:Cat]][[Category:Coagulation Defects\|Z]]
		+	[[Category:Lymphoreticular and Haematopoietic Diseases - Dog]]

← Older revision		Revision as of 15:20, 16 December 2010
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−	[[Category:Stomach_and_Abomasum_-_Pathology]] [[Category:Gastric ~~Pathology~~ - Dog]] [[Category:Cat]][[Category:Coagulation Defects\|Z]]	+	[[Category:Stomach_and_Abomasum_-_Pathology]] [[Category:Gastric Diseases - Dog]] [[Category:Cat]][[Category:Coagulation Defects\|Z]]

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 Laboratory tests are unlikely to show abnormalities until 36-72 hours after exposure, due to the delay in onset of haemorrhagic signs. Prothrombin time (PT) is a measure of functionality of the extrinsic (and common) pathway, and because factor VII has the shortest half life and thus becomes depleted most rapidly, this parameter is generally the first to become prolonged. Partial thromboplastin time (PTT) and activated clotting time (ACT) are related to the function of the intrinsic and common pathways, and usually become prolonged by 48-72 hours post-ingestion when levels of factor IX are reduced. Platelet count and buccal mucosal bleeding time assess platelet function, and since only secondary haemostasis is affected by vitamin K epoxide reductase antagonism, these measures are usually within normal limits.
-The 'proteins induced by vitamin K antagonism' (PIVKAs) are acarboxylated proteins that form as a result of anticoagulant rodenticide toxicity. PIVKAs are not normally detected in the circulation and are increased in the plasma of intoxicated animals. However, PIVKAs are rapidly cleared following adminstration of vitamin K, and so samples should be obtained before therapy is initiated.
+The 'proteins induced by vitamin K antagonism'(PIVKAs) are acarboxylated proteins that form as a result of anticoagulant rodenticide toxicity. PIVKAs are not normally detected in the circulation and are increased in the plasma of intoxicated animals. However, PIVKAs are rapidly cleared following adminstration of vitamin K, and so samples should be obtained before therapy is initiated.
 It may also be possible to assay vitamin K epoxide and specific anticoagulant in the blood, but these tests are not normally necessary.
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-[[Category:Stomach_and_Abomasum_-_Pathology]] [[Category:Dog]] [[Category:Cat]][[Category:Coagulation Defects|Z]]
+[[Category:Stomach_and_Abomasum_-_Pathology]] [[Category:Gastric Pathology - Dog]] [[Category:Cat]][[Category:Coagulation Defects|Z]]

← Older revision		Revision as of 18:17, 18 October 2010
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−	[[Category:Stomach_and_Abomasum_-_Pathology]] [[Category:Dog]] [[Category:Cat]][[Category:Coagulation Defects]]	+	[[Category:Stomach_and_Abomasum_-_Pathology]] [[Category:Dog]] [[Category:Cat]][[Category:Coagulation Defects\|Z]]