Benzimidazoles - Revision history

Bara at 22:09, 24 May 2011

2011-05-24T22:09:54Z

Amazonian at 13:51, 19 December 2010

2010-12-19T13:51:10Z

Suzannah.stacey at 18:36, 18 October 2010

2010-10-18T18:36:10Z

Jtulloch: /* Pharmacokinetics */

2008-11-03T14:20:41Z

Pharmacokinetics

Jtulloch: /* Spectrum of Activity */

2008-11-03T14:19:48Z

Spectrum of Activity

Jtulloch: New page: {{review}} {{toplink |linkpage =WikiDrugs |linktext =WikiDrugs |sublink1 = Anthelmintic Drugs |subtext1 = Anthelmintic Drugs |pagetype = Drugs }} This class of drugs are known by farmers ...

2008-11-03T14:11:21Z

New page: {{review}} {{toplink |linkpage =WikiDrugs |linktext =WikiDrugs |sublink1 = Anthelmintic Drugs |subtext1 = Anthelmintic Drugs |pagetype = Drugs }} This class of drugs are known by farmers ...

New page

{{review}}
{{toplink
|linkpage =WikiDrugs
|linktext =WikiDrugs
|sublink1 = Anthelmintic Drugs
|subtext1 = Anthelmintic Drugs
|pagetype = Drugs
}}

This class of drugs are known by farmers as white drenches. The product code in the UK is '''1-BZ'''. The most commonly used drugs in this category are; '''albendazole, fenbendazole''' and '''oxfendazole'''.

==Spectrum of Activity==
* Wide spectrum, they are active against '''adult and immature [[nematodes]]''', though have limited action against hypobiotic forms.
* Some have activity against the [[cestodes]].
* Albendazole has activity against adult [[trematodes|liver flukes]].
* Albendazole and fenbendazole are active against [[protozoa|Giardia]].
* '''Triclabendazole''' is active against all stages of ''Fasciola hepatica'', but inactive against nematodes and cestodes.
* They

@@ Line 1: / Line 1: @@
 This class of drugs are known by farmers as white drenches. The product code in the UK is '''1-BZ'''. The most commonly used drugs in this category are; '''albendazole, fenbendazole''' and '''oxfendazole'''.
@@ Line 20: / Line 19: @@
 ==Safety==
 * Some members of this group are '''teratogenic'''. Thus they should not be used in pregnant animals.

← Older revision		Revision as of 13:51, 19 December 2010
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	==Safety==		==Safety==
−	* Some members of this group are '''~~tetragenic~~'''. Thus they should not be used in pregnant animals.	+	* Some members of this group are '''teratogenic'''. Thus they should not be used in pregnant animals.

@@ Line 1: / Line 1: @@
 {{review}}
 This class of drugs are known by farmers as white drenches. The product code in the UK is '''1-BZ'''. The most commonly used drugs in this category are; '''albendazole, fenbendazole''' and '''oxfendazole'''.
 ==Spectrum of Activity==
@@ Line 18: / Line 9: @@
 * '''Triclabendazole''' is active against all stages of ''Fasciola hepatica'', but inactive against nematodes and cestodes.
 * They work by binding to tubulin. This caps the ends of microtubules in the parasites, resulting in disruption in their intestinal and integumental cells. Thus they can't utilise glucose efficiently and they starve to death.
 ==Pharmacokinetics==
@@ Line 27: / Line 17: @@
 * In ruminants, the potency is increased by starving them for 12-24 hours, as the transit time through the gut will be increased. This is the opposite in carnivores.
 * These drugs are often given in a pro-drug form which is metabolised to the sulphoxide form of the drug (the most potent form) and then to the inactive sulphone form. '''Netobimin''' is the prodrug of albendazole, whilst '''febantel''' is the prodrug fenbendazole.
 ==Safety==
 * Some members of this group are '''tetragenic'''. Thus they should not be used in pregnant animals.

← Older revision		Revision as of 14:20, 3 November 2008
Line 27:		Line 27:
	* In ruminants, the potency is increased by starving them for 12-24 hours, as the transit time through the gut will be increased. This is the opposite in carnivores.		* In ruminants, the potency is increased by starving them for 12-24 hours, as the transit time through the gut will be increased. This is the opposite in carnivores.
	* These drugs are often given in a pro-drug form which is metabolised to the sulphoxide form of the drug (the most potent form) and then to the inactive sulphone form. '''Netobimin''' is the prodrug of albendazole, whilst '''febantel''' is the prodrug fenbendazole.		* These drugs are often given in a pro-drug form which is metabolised to the sulphoxide form of the drug (the most potent form) and then to the inactive sulphone form. '''Netobimin''' is the prodrug of albendazole, whilst '''febantel''' is the prodrug fenbendazole.
		+
		+
		+	==Safety==
		+	* Some members of this group are '''tetragenic'''. Thus they should not be used in pregnant animals.