Bronchiectasis - Revision history

Bara at 18:48, 19 February 2011

2011-02-19T18:48:54Z

Bara at 17:35, 19 February 2011

2011-02-19T17:35:24Z

Bara at 16:32, 19 February 2011

2011-02-19T16:32:34Z

Bara: Created page with "Bronchiectasis (Image sourced from Bristol Biomed Image Archive with permission) [[Image:Bronchiect..."

2011-02-19T16:03:20Z

Created page with "right|thumb|100px|<center>Bronchiectasis (Image sourced from Bristol Biomed Image Archive with permission)</center> [[Image:Bronchiect..."

New page

[[Image:Bronchiectasis.jpg|right|thumb|100px|<center>Bronchiectasis (Image sourced from Bristol Biomed Image Archive with permission)</center>]]
[[Image:Bronchiectasis micro.jpg|right|thumb|100px|<center>Bronchiectasis (Image sourced from Bristol Biomed Image Archive with permission)</center>]]

*Permanent, abnormal saccular or cylindrical dilation of bronchi
*Accumulation of exudate within the lumen and partial rupture of bronchial walls
*Sequel to [[Bronchi and Bronchioles Inflammatory - Pathology#Chronic bronchitis|chronic bronchitis]] as result of an unresolved persistent [[Lungs Inflammatory - Pathology#Bronchopneumonia|bronchopneumonia]]
*Chronic inflammation within the bronchial mucosa and wall -> release of proteolytic enzymes from [[Neutrophils|neutrophils]] and macrophages -> destruction of supporting structures in the bronchial walls (eg: cartilage, connective tissue) -> weakens the bronchial walls and damages lining mucosal epithelial cells and their cilia (damage to mucociliary escalator)
*[[Lungs Ventilation - Pathology#Atelectasis|Atelectasis]] in the surrounding lung parenchyma results in increased inspiratory effort and increased intrathoracic negative pressure during inspiration
*The weakened bronchial walls are less able to 'resist' the negative pressure and therefore dilate excessively.
*With time this dilation becomes permanent as a viscous cycle of exudate pooling in the lumen and increased contact of the bronchial walls with the leukocytes further weakens the bronchial walls.
*Most severe in cattle (complete lobular septation and lack of collateral ventilation), least severe in dogs (good colateral ventilation), also seen in sheep, goats and pigs
*In very severe cases, the bronchial wall is completely destroyed and unrecognisable - an abscess

==Test yourself with the Bronchi and Bronchioles Pathology Flashcards==

[[Bronchi_and_Bronchioles_Flashcards_-_Pathology|Bronchi and Bronchioles Pathology Flashcards]]

[[Category:Bronchi and Bronchioles - Pathology]]
[[Category:Respiratory System - Inflammatory Pathology]]

@@ Line 5: / Line 5: @@
 *Permanent, abnormal saccular or cylindrical dilation of  bronchi
 *Accumulation of exudate within the lumen and partial rupture of bronchial walls
-*Sequel to [[Bronchitis#Chronic bronchitis|chronic bronchitis]] as result of an unresolved persistent [[Lungs Inflammatory - Pathology#Bronchopneumonia|bronchopneumonia]]
+*Sequel to [[Bronchitis#Chronic bronchitis|chronic bronchitis]] as result of an unresolved persistent [[Bronchopneumonia|bronchopneumonia]]
 *Chronic inflammation within the bronchial mucosa and wall -> release of proteolytic enzymes from [[Neutrophils|neutrophils]] and macrophages  ->  destruction of supporting structures in the bronchial walls (eg: cartilage, connective tissue) -> weakens the bronchial walls and damages lining mucosal epithelial cells and their cilia (damage to mucociliary escalator)
 *[[Atelectasis|Atelectasis]] in the surrounding lung parenchyma results in increased inspiratory effort and increased intrathoracic negative pressure during inspiration

@@ Line 7: / Line 7: @@
 *Sequel to [[Bronchitis#Chronic bronchitis|chronic bronchitis]] as result of an unresolved persistent [[Lungs Inflammatory - Pathology#Bronchopneumonia|bronchopneumonia]]
 *Chronic inflammation within the bronchial mucosa and wall -> release of proteolytic enzymes from [[Neutrophils|neutrophils]] and macrophages  ->  destruction of supporting structures in the bronchial walls (eg: cartilage, connective tissue) -> weakens the bronchial walls and damages lining mucosal epithelial cells and their cilia (damage to mucociliary escalator)
-*[[Lungs Ventilation - Pathology#Atelectasis|Atelectasis]] in the surrounding lung parenchyma results in increased inspiratory effort and increased intrathoracic negative pressure during inspiration
+*[[Atelectasis|Atelectasis]] in the surrounding lung parenchyma results in increased inspiratory effort and increased intrathoracic negative pressure during inspiration
 *The weakened bronchial walls are less able to 'resist' the negative pressure and therefore dilate excessively.
 *With time this dilation becomes permanent as a viscous cycle of exudate pooling in the lumen and increased contact of the bronchial walls with the leukocytes further weakens the bronchial walls.