Category:Leptospiraceae - Revision history

Bara at 15:09, 14 December 2010

2010-12-14T15:09:48Z

Bara at 13:49, 20 July 2010

2010-07-20T13:49:10Z

Aimee.e.hicks at 11:03, 20 July 2010

2010-07-20T11:03:06Z

Aimee.e.hicks at 10:58, 20 July 2010

2010-07-20T10:58:18Z

Eca02csb at 19:35, 19 July 2010

2010-07-19T19:35:24Z

Eca02csb at 19:34, 19 July 2010

2010-07-19T19:34:47Z

Aimee.e.hicks at 10:59, 19 July 2010

2010-07-19T10:59:30Z

Aimee.e.hicks at 10:56, 19 July 2010

2010-07-19T10:56:42Z

Aimee.e.hicks at 10:56, 19 July 2010

2010-07-19T10:56:10Z

Bara at 10:59, 25 June 2010

2010-06-25T10:59:06Z

← Older revision		Revision as of 15:09, 14 December 2010
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−	~~[[Category:To_Do_-_AimeeHicks]]~~

← Older revision		Revision as of 13:49, 20 July 2010
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	[[Category:To_Do_-_AimeeHicks]]		[[Category:To_Do_-_AimeeHicks]]
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← Older revision		Revision as of 11:03, 20 July 2010
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	[[Category:To_Do_-_AimeeHicks]]		[[Category:To_Do_-_AimeeHicks]]
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 {{frontpage
 |pagetitle =Leptospiraceae
-|pagebody =
+|pagebody =''Leptospiraceae'' is a family of [[Spirochaetes species - Overview|''spirochaetes'']]. It includes the genus ''Leptospira'' which causes Leptospirosis in all animals.
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-[[File:Leptospira.jpg|right|thumb|250px|<small><center> Leptospira acanning micrograph. (Rob Weyant 1998, WikiMedia Commons)</center></small>]]
+[[File:Leptospira.jpg|right|thumb|250px|<small><center> Leptospira Scanning Micrograph. (Rob Weyant 1998, WikiMedia Commons)</center></small>]]
 ''Leptospiraceae'' is a family of [[Spirochaetes species - Overview|''spirochaetes'']]. It includes the genus ''Leptospira''.

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-*Motile, helical bacteria found in aquatic environments
+==Overview==
-*Require liquid media for culture
+''Leptospira'' is a motile, helical bacteria found in aquatic environments. It causes leptospirosis in all animals, which can range from mild urogenital tract infections to systemic diseases. The organisms persist in the kidney tubules or genital tracts of carrier animals and are shed in urine. Transmission occurs via direct contact. Maintenance hosts may transmit the infection to incidental hosts, which are less susceptible to infection, but develop serious disease. ''Leptospira'' may cause severe systemic disease, resulting in [[Septicaemia and Enteritis, Bacterial|enteritis]].
-*Diagnosis
+==Pathogenesis==
-**Clinical signs and history of exposure
+The pathogenesis of ''Leptospira'' depends on virulence of the bacteria and susceptibility of the host. Leptospires invade tissues through moist skin or via mucous membranes, aided by their motility. They may invade via receptor-mediated endocytosis and then pass through the body via the blood stream. Antibodies clear the organisms from the blood stream after about 10 days of infection.
-**Dark-field microscopy of urine may detect organisms
-**Isolation from blood or urine by culture or animal inoculation
+The organisms may persist in the renal tubules, uterus, eye or meninges. They evade phagocytosis possibly via macrophage apoptosis and damage red blood cell membranes and endothelial and liver cells, leading to haemolytic anaemia, jaundice, [[Pigmentation and Calcification - Pathology#Haemoglobin|haemoglobin pigmentation]], haemoglobinuria and haemorrhage in acute leptospirosis.
-**Identificaiton or certain serovars using DNA probes and serology
-**FLuorescent antibody technique for identification in tissues
+==Diagnosis==
-**Silver impregnation
+''Leptospira'' can be diagnosed by clinical signs and history of exposure. Dark-field microscopy of urine may detect organisms as may isolation from blood or urine by culture or animal inoculation.
-**Molecular techniques such as PCR
+The fluorescent antibody technique can be used for identification in tissues. Silver impregnation, molecular techniques such as PCR and Serology using microscopic agglutination test or ELISA can also be used.
 [[Category:Spirochaetes]]
-[[Category:To_Do_-_Bacteria]]

← Older revision		Revision as of 10:59, 25 June 2010
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	[[Category:Spirochaetes]]		[[Category:Spirochaetes]]
		+	[[Category:To_Do_-_Bacteria]]