Category:Myocardial Pathology - Revision history

Bara at 15:38, 24 February 2011

2011-02-24T15:38:43Z

Bara at 18:47, 15 February 2011

2011-02-15T18:47:49Z

Bara at 12:59, 1 July 2010

2010-07-01T12:59:28Z

Bara at 14:26, 23 June 2010

2010-06-23T14:26:11Z

Bara at 14:25, 23 June 2010

2010-06-23T14:25:10Z

Bara at 14:23, 23 June 2010

2010-06-23T14:23:03Z

Bara at 14:21, 23 June 2010

2010-06-23T14:21:11Z

Bara at 14:08, 23 June 2010

2010-06-23T14:08:46Z

Bara at 14:02, 23 June 2010

2010-06-23T14:02:22Z

Bara at 14:00, 23 June 2010

2010-06-23T14:00:45Z

@@ Line 15: / Line 15: @@
 Blood supply is from the coronary arteries, sinuses beind the leaflets of the aortic valve allow entry of blood into the coronary system at diastole.
-Disease of the myocardium may be incidental at post mortem and cause no clinical signs, or may be clinically evident.  Disease must be severe and widespread to lead to observable clinical signs.  Myocardial disease most often leads to [[Cardiovascular Conditions - WikiClinical#Heart Failure|heart failure]].
+Disease of the myocardium may be incidental at post mortem and cause no clinical signs, or may be clinically evident.  Disease must be severe and widespread to lead to observable clinical signs.  Myocardial disease most often leads to [[:Category:Heart Failure|heart failure]].
 The heart cannnot regenerate by hyperplasia and so responds with hypertrophic change in order to maintain normal function.

@@ Line 24: / Line 24: @@
 </b></big>
-|logo =
+|logo =path-logo.png
 }}

← Older revision		Revision as of 12:59, 1 July 2010
Line 29:		Line 29:

	[[Category:Cardiovascular_System_-_Pathology]]		[[Category:Cardiovascular_System_-_Pathology]]
		+	[[Category:To_Do_-_Cardiovascular]]

@@ Line 26: / Line 26: @@
 |logo =
 }}
 [[Category:Cardiovascular_System_-_Pathology]]

← Older revision		Revision as of 14:25, 23 June 2010
Line 34:		Line 34:


−	===Thrombosis===	+	===[[Myocardial Thrombosis]]===
		+

−	~~Myocardial infarction rare in animals. May be seen with septicaemias.~~
	[[Category:Cardiovascular_System_-_Pathology]]		[[Category:Cardiovascular_System_-_Pathology]]

@@ Line 26: / Line 26: @@
 |logo =
 }}
 ==Vascular pathology==
-===Haemorrhage===
+===[[Myocardial Haemorrhage]]===
 ===Thrombosis===

← Older revision		Revision as of 14:21, 23 June 2010
Line 50:		Line 50:


−	==Inflammatory-Myocarditis==	+	==Inflammatory-[[Myocarditis]]==

−	~~Most often due to an infective agent. In most cases myocarditis is a result of a generalised infection, myocarditis is rarely an isolated primary condition.~~
−	~~Classified as:~~
−
−	~~===Acute Suppurative===~~
−
−	~~Follows from the dissemination of septic emboli form suppurative foci therefore always follows pyaemia. Original septic foci may be:~~
−	*Joint ill.
−	*Umbilical abcess.
−	*Metritis.
−	*Mastitis.
−	*Valvular endocarditis.
−
−	~~May also be a result of extension from the endocarium or pericardium.~~
−
−	~~===Acute non-suppurative===~~
−	~~[[Image:parvovirus dog.jpg\|right\|thumb\|125px\|<small><center>'''Parvovirus (dog)'''. Courtesy of T. Scase</center></small>]]~~
−
−	~~Usually results from a septicaemia or viraemia E.g [[Parvoviridae\|Parvovirus]] infection in puppies.~~
−	~~Also includes:~~
−	*Foot and Mouth Disease.
−	*Leptospirosis.
−	*Pasteurellosis.
−
−	~~'''''Parvovirus Infection of puppies''''':~~
−
−	Parvovirus affects rapidly dividing cells which are found in the GI tract, and in the growing pup, the myocardium. Myocardial cells divide up to approximately 2 weeks of age and so this is when the infection has an effect although clinical signs may not become apparent until later in life.
−
−	~~[[Image:Parvovirus myocarditis.jpg\|right\|thumb\|125px\|<small><center>'''Parvoviral Myocarditis'''. Courtesy of A. Jefferies</center></small>]]~~
−
−	~~Two cardiac syndromes exist:~~
−	*'''Sudden death, 3-8 weeks:''' Cardiac failure with pulmonary oedema etc. Histologically see multifocal myocardial necrosis due to viral replication within the myocardium. May see large basophilic intranuclear inclusion bodies.
−	*'''Puppies >8 weeks:''' See dyspoea, weakness, collapse and death within 24 hours. In this case cardiac failure occurs due to myocardial fibrosis.
−
−	~~===Chronic===~~
−
−	~~Myofibrils replaced by fibrous tissue during healing. May be a sequale of previous acute myocarditis.~~
−
−	~~===Parasites===~~
−
−	~~Parasites also may cause myocarditis. parasitic larvae may encyst in the myocardium, including:~~
−	*Cysticercosis.
−	*Sarcocystis.
−	*[[Tissue_cyst-forming_coccidia\|Toxoplasmosis]].

	==Vascular pathology==		==Vascular pathology==

← Older revision		Revision as of 14:08, 23 June 2010
Line 48:		Line 48:


−	~~==Degenerative-Cardiomyopathy==~~

−	~~The majority of cardiomyopahies in domestic species are idiopathic in aetiology. There are three forms if idiopathic cardiomyopathy:~~
−	*[[Myocardial - Pathology#Dilated cardiomyopathy\|Dilated]]
−	*[[Myocardial - Pathology#Hypertrophic cardiomyopathy\|Hypertrophic]]
−	*[[Myocardial - Pathology#Restrictive cardiomyopathy\|Restrictive]]
−
−	~~===Dilated cardiomyopathy===~~
−
−	~~''Incidence:''~~
−
−	~~Most common form in the dog. Seen in young to middle aged dogs of large breeds:~~
−	*St Bernard
−	*Great Dane
−
−	~~''Clinical signs:''~~
−
−	Disease is a slowly progressive dilation of the ventricles with a loss of contractility. This is seen histologically as random myofibrillar thinning and degeneration of myocyte mitochonria, although it is possible that no histological lesions are present.
−
−	~~Clinical signs will appear as a sudden onset disease as there will be an acute decompensation for the pathology that had accumulated gradually. Signs include those of a congestive heart failure:~~
−	*Pulmonary oedema.
−	*Ascites.
−	*Hepatomegaly and splenomegaly.
−
−	~~''Diagnosis:''~~
−
−	~~Gross cardiomegaly with cardiac hypertrophy, dilation and decreased contractility.~~
−	~~Histopathologically; increased ''attenuated wavy fibres'' within the myocardium. Fibres are thinner than normal and have a wavy appearance. May develop due to a chronic volume overload.~~
−
−	*Ventricular dilation, particularly the left ventricle, distorts the AV-valves which often become incompetant.
−	*'''Fibrillation''' is a common finding as dilation of the myocardium induces abnormal electrical activity and arrhythmias.
−
−	~~Variations of the disease exist in specific breeds:~~
−	*'''Doberman''': Present with arrhythmias. Histologically there are lymphocytic infiltrates within the ventricular myocardium. See focal degeneration of the bundle of His, probably due to narrowing of small vessels near the conductive tissue.
−	*'''English Cockers:''' Familial with many dogs having sub-clinical disease.
−
−
−	~~[http://w3.vet.cornell.edu/nst/nst.asp?Fun=F_Ssrch View images courtesy of Cornell Veterinary Medicine]~~
−
−	~~===Hypertrophic cardiomyopathy===~~
−
−	~~[[Image:hypertrophic cardiomyopathy.jpg\|right\|thumb\|125px\|<small><center>'''Hypertrophic cardiomyopathy (cat)'''. Courtesy of T. Scase</center></small>]]~~
−
−	~~''Incidence:''~~
−
−	~~The cat is most commonly affected.~~
−	~~There is some evidence of inheritance, as in man, and the disease is said to be more common in male cats. There is a wide age range of 7 months to 24 years.~~
−
−	~~Inherited in Maine Coon cats.~~
−
−	~~''Clinical signs:''~~
−
−	~~Grossly there is disproportionate hypertrophy of the left ventricle and often the interventricular septum. The chamber size is dramatically reduced.~~
−
−	~~Histologically there is haphazard hypertrophy of the myocardial fibres.~~
−
−	The reduction in left ventricular volume and the stiffened ventricular wall results in diastolic dysfunction, the stroke volume is reduced resulting in congestive heart failure and the following clinical signs:
−
−	~~[[Image:hypertrophic cardiomyopathy 2.jpg\|right\|thumb\|125px\|<small><center>'''Hypertrophic cardiomyopathy (cat)'''. Courtesy of T. Scase</center></small>]]~~
−
−	*Tachycardia.
−	*Arrhythmia (abnormal myocardium)
−	*Dyspnoea.
−
−	~~The force of the left ventricular contraction reduces afterload and reduces end-systolic volume to zero in some cases. This is '''cavity obliteration'''.~~
−
−	*[[Atrial_Thrombosis\|Thromboembolic disease]] is a frequent complication. The thromboemboli most often impact in the femoral arteries manifesting as an acute hindlimb paralysis.
−
−	~~===Restrictive cardiomyopathy===~~
−
−	Described clinically in cats and cattle. There is fibrosis and thickening of the left ventricle which allows decreased filling and so diastolic dysfunction. There is left atrial dilation to cope with the increased difficulty in filling the left ventricle and this predisposes to [[Atrial_Thrombosis\|thromboembolic disease]].
−	~~'''Atrial fibrillation''' is also a common finding.~~
−
−	~~''Clinical signs:''~~
−
−	~~Left sided heart failure and so:~~
−	*Pulmonary oedema, plus...
−	*Thromboembolism, usually hindlimb paralysis.
−
−	~~In cattle the disease appears to have an inherited pathogenesis. Disease is seen in:~~
−	*Polled Herefords with curly hair coats.
−	*Friesian Holsteins with a common sire.
−
−	~~===Other Cardiomyopathies===~~
−
−	~~====Feline Hyperthyroidism====~~
−
−	~~A hypertrophic cardiomyopathy is seen secondary to this disease in elderly cats. Thyroid hormones induce the growth of the myocardium.~~
−
−	~~====Secondary to toxic agents====~~
−
−	~~Includes:~~
−	*Dilated myopathy in horses with '''monensin''' toxicity.
−	*Dilated myopathy in dogs with long term administration of '''doxorubicin'''.
−	*Dilated myopathy in cats due to '''taurine''' deficiency.

	==Inflammatory-Myocarditis==		==Inflammatory-Myocarditis==

← Older revision		Revision as of 14:02, 23 June 2010
Line 45:		Line 45:


−	===Mineralisation===	+	===[[Myocardial Mineralisation]]===

−	*'''Dytrophic''': Calcium is deposited due to damage of the myocyte. Myocyte damage may be:
−	**Hypoxia.
−	**Vitamin E/Selenium deficiency.
−	*'''Metastatic''': Occurs with elevated serum calcium for example will occur with:
−	**Vitamin D toxicity.
−	**Secondary hyperparathyroidism.

	==Degenerative-Cardiomyopathy==		==Degenerative-Cardiomyopathy==

← Older revision		Revision as of 14:00, 23 June 2010
Line 41:		Line 41:


−	===Lipofuscinosis===	+	===[[Lipofuscinosis]]===
		+

−	Also known as '''Brown atrophy'''. Lipofuscins are a class of fatty pigments formed when a pigment is dissolved in fat. Known as ''wear and tear'' pigments, they become deposited with advancing age and Vitamin E/Selenium deficiency.
−	~~Also ay be breed related, seen in Ayreshires.~~

	===Mineralisation===		===Mineralisation===