Category:Rhabdoviridae - Revision history

Kitnmre at 00:12, 16 June 2016

2016-06-16T00:12:40Z

Kitnmre at 00:11, 16 June 2016

2016-06-16T00:11:28Z

Bara at 20:09, 8 June 2011

2011-06-08T20:09:07Z

Suzannah.stacey at 09:27, 24 August 2010

2010-08-24T09:27:02Z

Bara: Text replace - "Category:To_Do_-_Viruses" to "Category:To_Do_-_Clinical/Viruses"

2010-07-30T12:28:32Z

Text replace - "Category:To_Do_-_Viruses" to "Category:To_Do_-_Clinical/Viruses"

Bara at 22:57, 26 June 2010

2010-06-26T22:57:43Z

Bara at 10:15, 24 May 2010

2010-05-24T10:15:32Z

Bara at 10:12, 24 May 2010

2010-05-24T10:12:40Z

Bara at 13:12, 23 May 2010

2010-05-23T13:12:18Z

Bara: Created page with '{{unfinished}} =Introduction= Rabies is a neurological killer that has evolved a fool-proof technique of transmission, and it cleverly evades the species barrier to present …'

2010-05-21T13:52:29Z

Created page with '{{unfinished}} =Introduction= Rabies is a neurological killer that has evolved a fool-proof technique of transmission, and it cleverly evades the species barrier to present …'

New page

{{unfinished}}

=Introduction=
[[Rabies]] is a neurological killer that has evolved a fool-proof technique of transmission, and it cleverly evades the species barrier to present a potent threat to mammalian life. While the simplicity of the virus ensures its transmission, it also contributes to its weakness: its monoclonal antigenicity means that a single vaccination covers all strains of the disease. Though rabies is considered endemic in parts of the developed and undeveloped world, vaccination schemes have rendered the disease controllable to a satisfactory degree. Nonetheless, infection is still largely fatal and the disease should not be taken lightly.

=Morphology=
*Large, enveloped, negative-sense RNA virus
*'''Bullet-shaped''' with short glycoprotein spikes

=Types and Subtypes=
Two Genera:
#Lyssaviruses: 7 genotypes
##'''Genotype 1''' is '''classical rabies'''
##Genotypes 2-7 more limited in distribution
##Genotype 4 infects '''insectivorous bats'''
#Vesiculoviruses are all '''exotic''' to the UK:
##Vesicular Stomatitis Virus
##Ephemeral Fever
##Fish Rhabdoviruses, such as viral hemorrhagic syndrome and infectious haematopoetic necrosis virus

=Virulence and Pathogenesis=
*Rabies is moderately resistant: it can survive well in dark places at low temperatures for several days
*Infection occurs through a '''penetrating bite''' in which virus is transmitted via '''saliva'''
*'''Incubation''' period is variable but can be long (10 days to 12 months), and increases with distance of the bite to the CNS
**80% show signs within 4 months
*Primary replication of the virus occurs in the '''muscle'''
*The virus gains access to nervous tissue and travels toward the '''brain''', where it continues to replicate
*It then migrates down cranial nerves to infect salivary glands and the cornea
*Virus is shed in '''saliva''' and '''tears''' and can be shed BEFORE the onset of classical signs
*The onset of clinical signs in dogs and cats includes:
**Behavioral changes
**Pyrexia
**Salivation
**Dilation of pupils
*Two forms of the virus exist:
**'''Furious''' form:
***Common to cats and dogs
***Abnormal aggression, salivation, and attack without provocation
***Disordered wandering, "copulatory" movements.
***Incoordination, convulsions, coma and death within 3-10 days
**'''Dumb''' form
***May or may not follow Furious form
***Common to ruminants and horses
***Ruminal tympany, tenesmus, diarrhoea
***Paralysis of lower jaw, drooling saliva, tremors and progressive paralysis
***In dogs, a change in voice may be observed (bellowing)
*Human infection is characterized by '''hydrophobia'''

[[Category:Viruses]]

@@ Line 27: / Line 27: @@
-{{Learning |Vetstream = [https://www.vetstream.com/felis/Content/Bug/bug00214.asp Rabies]}}
+{{Learning |Vetstream = <P>[https://www.vetstream.com/felis/Content/Bug/bug00214.asp Rabies]</P><P>[https://www.vetstream.com/equis/Content/Disease/dis01018.asp Vesicular Stomatitis Virus]</P>}}
 [[Category:Viral Organisms]]
 [[Category:To_Do_-_Clinical/Viruses]]

← Older revision		Revision as of 00:11, 16 June 2016
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		+	{{Learning \|Vetstream = [https://www.vetstream.com/felis/Content/Bug/bug00214.asp Rabies]}}


	[[Category:Viral Organisms]]		[[Category:Viral Organisms]]
	[[Category:To_Do_-_Clinical/Viruses]]		[[Category:To_Do_-_Clinical/Viruses]]

← Older revision		Revision as of 09:27, 24 August 2010
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−	[[Category:~~Viruses~~]]	+	[[Category:Viral Organisms]]
	[[Category:To_Do_-_Clinical/Viruses]]		[[Category:To_Do_-_Clinical/Viruses]]

← Older revision		Revision as of 12:28, 30 July 2010
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	[[Category:Viruses]]		[[Category:Viruses]]
−	[[Category:To_Do_-~~_Viruses~~]]	+	[[Category:To_Do_-_Clinical/Viruses]]

← Older revision		Revision as of 22:57, 26 June 2010
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	[[Category:Viruses]]		[[Category:Viruses]]
		+	[[Category:To_Do_-_Viruses]]

@@ Line 22: / Line 22: @@
 ##Genotype 4 infects '''insectivorous bats'''
 #Vesiculoviruses are all '''exotic''' to the UK:
-##Vesicular Stomatitis Virus
+##[[Vesicular Stomatitis Virus]]
 ##Ephemeral Fever
 ##Fish Rhabdoviruses, such as viral hemorrhagic syndrome and infectious haematopoetic necrosis virus

@@ Line 8: / Line 8: @@
 <br><br>
 <categorytree mode=pages>Rhabdoviridae</categorytree>
-|logo =Vesicular stomatitis virus logo.jpg
+|logo =Vesicular stomatitis virus logo.png
 }}
@@ Line 26: / Line 26: @@
 ##Fish Rhabdoviruses, such as viral hemorrhagic syndrome and infectious haematopoetic necrosis virus
-==Virulence and Pathogenesis==
 [[Category:Viruses]]

@@ Line 1: / Line 1: @@
-{{unfinished}}
+{{frontpage
-=Introduction=
+<categorytree mode=pages>Rhabdoviridae</categorytree>
-[[Rabies]] is a neurological killer that has evolved a fool-proof technique of transmission, and it cleverly evades the species barrier to present a potent threat to mammalian life.  While the simplicity of the virus ensures its transmission, it also contributes to its weakness: its monoclonal antigenicity means that a single vaccination covers all strains of the disease.  Though rabies is considered endemic in parts of the developed and undeveloped world, vaccination schemes have rendered the disease controllable to a satisfactory degree.  Nonetheless, infection is still largely fatal and the disease should not be taken lightly.
+|logo =
-=Morphology=
+==Morphology==
 *Large, enveloped, negative-sense RNA virus
 *'''Bullet-shaped''' with short glycoprotein spikes
-=Types and Subtypes=
+==Types and Subtypes==
 Two Genera:
 #Lyssaviruses: 7 genotypes
@@ Line 19: / Line 26: @@
 ##Fish Rhabdoviruses, such as viral hemorrhagic syndrome and infectious haematopoetic necrosis virus
-=Virulence and Pathogenesis=
+==Virulence and Pathogenesis==
 *Rabies is moderately resistant: it can survive well in dark places at low temperatures for several days
 *Infection occurs through a '''penetrating bite''' in which virus is transmitted via '''saliva'''