Cellular Fatty Change - Revision history

Jwills: /* Gross Appearance of Fatty Change */

2014-12-24T14:14:20Z

Gross Appearance of Fatty Change

Jwills: /* Histological Appearance of Fatty Change */

2014-12-24T14:03:26Z

Histological Appearance of Fatty Change

Jwills: /* Introduction */

2014-12-24T13:52:51Z

Introduction

Juntespo at 07:56, 7 April 2014

2014-04-07T07:56:19Z

Bara at 14:52, 15 October 2013

2013-10-15T14:52:20Z

Bara at 14:34, 15 February 2011

2011-02-15T14:34:24Z

Bara at 14:22, 15 February 2011

2011-02-15T14:22:19Z

Bara at 15:02, 14 February 2011

2011-02-14T15:02:45Z

Bara: Text replace - "[[Haemorrhage - Pathology" to "[[Haemorrhage"

2011-02-14T14:54:57Z

Text replace - "[[Haemorrhage - Pathology" to "[[Haemorrhage"

Bara at 14:28, 14 February 2011

2011-02-14T14:28:41Z

@@ Line 17: / Line 17: @@
 * [[Liver - Anatomy & Physiology|Liver]]
 ** This is the main organ involved in fatty change.
-** May be greatly increased in size.
+** May be greatly increased in size with rounded edges.
 ** Is tan to yellowish in colour.
 *** Is normally reddish brown.
@@ Line 33: / Line 33: @@
 *** I.e. those muscles furthest away from the blood supply.
 ** Contractile ability is reduced, and blood is therefore not pumped efficiently.
 ===Histological Appearance of Fatty Change===

@@ Line 38: / Line 38: @@
 ===Histological Appearance of Fatty Change===
-* The fat either appears as globules or is contained in varying sizes of vacuoles in the cytoplasm.
+* Fat appears as clear colourless vacuoles of varying sizes in the cell cytoplasm.
 ** In the heart, fat appears as groups of tiny vacuoles dispersed along the myofibrils.
 ** In the [[Liver - Anatomy & Physiology|liver]] and kidney, vacuoles tend to coalesce to form larger ones.
-*** One or more large globules may fill the cytoplasm.
+*** One or more large vacuoles may fill the cytoplasm.
 **** The nucleus is displaced to the periphery of the cell.
 * The nucleus remains normal.
@@ Line 51: / Line 51: @@
 ** Stains commonly used include Sudan III, Sudan IV, and Oil Red O.
 *** Stain fat varying shades of orange to red.
-** Sections must be prepared differently to the routine paraffin embedding (used e.g. in H&E staining).
+** The strong solvents used in paraffin embedding dissolve the fat out of the cell.
-*** The strong solvents used in paraffin embedding dissolve the fat out of the cell.
+*** Sections must therefore be prepared differently to the routine paraffin embedding (used e.g. in H&E staining).
-*** When staining for fat,  the tissue to be examined is frozen and sectioned in a cryostat before being stained.
+*** When staining for fat, the tissue to be examined is frozen and sectioned in a cryostat before being stained.
 **** These sections are more than twice as thick as those attained by sectioning paraffin blocks
 ***** There may be some overlap of cells on the section.

@@ Line 1: / Line 1: @@
 ==Introduction==
 * ''NB This term does not refer to the fat stores within the body!''
-** Fatty substances accumulate or increase within the cytoplams of specific cells.
+** Fatty substances accumulate or increase within the cytoplasm of specific cells.
 ** In some instances, the fat stores may be involved in the transfer of fat to these specific cells.
 * Cellular fatty change is an important intracellular abnormality.

@@ Line 49: / Line 49: @@
 *** [[Hydropic Degeneration#Vacuolar Degeneration|Vacuolar hydropic degeneration]]
 *** Glycogen accumulation
-** Stains commonly used include Sudan 111, Sudan 1V, and Oil Red O.
+** Stains commonly used include Sudan III, Sudan IV, and Oil Red O.
 *** Stain fat varying shades of orange to red.
 ** Sections must be prepared differently to the routine paraffin embedding (used e.g. in H&E staining).

← Older revision		Revision as of 14:52, 15 October 2013
Line 169:		Line 169:
	[[Category:Myocardial_Pathology]]		[[Category:Myocardial_Pathology]]
	[[Category:Cardiovascular_System_-_Metabolic_Pathology]]		[[Category:Cardiovascular_System_-_Metabolic_Pathology]]
		+	[[Category:Cardiology Section]]

@@ Line 47: / Line 47: @@
 * In hepatocytes, it is necessary to stain for fat in order to ellucidate if a vacuole in the cytoplasm is fat-containing.
 ** Two further conditions may produce vacuoles in hepatocytes.
-*** [[Degenerations and Infiltrations - Pathology#Vacuolar Degeneration|Vacuolar hydropic degeneration]]
+*** [[Hydropic Degeneration#Vacuolar Degeneration|Vacuolar hydropic degeneration]]
 *** Glycogen accumulation
 ** Stains commonly used include Sudan 111, Sudan 1V, and Oil Red O.

← Older revision		Revision as of 14:22, 15 February 2011
Line 158:		Line 158:


−	[[Category:~~Myocardial_Pathology~~]][[Category:~~General Pathology~~]]	+
		+
		+
		+	Cellular fatty change is an important intracellular abnormality where fatty substances accumulate or increase within the cytoplasm of specific cells.
		+	Principally this pathology affects the intracellular fat in hepatocytes, but the kidney and the heart can also be involved in [[Cellular Fatty Change\|cellular fatty changes]]. These organs are susceptible as they are involved in the metabolism of fat, or are dependant upon lipids as an energy source. In some instances, the fat stores may be involved in the transfer of fat to these specific cells.
		+	Fatty change can be readily recognised at post-mortem.
		+
		+
		+	[[Category:Degenerations and Infiltrations]]
		+	[[Category:Myocardial_Pathology]]
	[[Category:Cardiovascular_System_-_Metabolic_Pathology]]		[[Category:Cardiovascular_System_-_Metabolic_Pathology]]

@@ Line 107: / Line 107: @@
 **** Excessive destruction of erythrocytes (haemolysis).
 ** Circulatory disorders
-*** [[Ischaemia and Infarction - Pathology#Ischaemia|Ischaemia]]
+*** [[Ischaemia|Ischaemia]]
 **** Reduced blood supply to a tissue
 *** Chronic [[Venous Congestion|venous congestion]]

@@ Line 151: / Line 151: @@
 * '''Extracellular accumulation of lipids'''
 ** [[Necrosis - Pathology|Necrosis]] of cells containing lipid may release lipid into the extracellular space.
-*** [[Haemorrhage - Pathology|Haemorrhage]] or tissue damage may result in cholesterol being released from cells or pooled from lipoproteins in crystalline form (cholesterol clefts).
+*** [[Haemorrhage|Haemorrhage]] or tissue damage may result in cholesterol being released from cells or pooled from lipoproteins in crystalline form (cholesterol clefts).
 ==Cardiac==