Chondrodysplasia - Revision history

Bara at 16:03, 3 March 2011

2011-03-03T16:03:50Z

Bara at 18:19, 27 February 2011

2011-02-27T18:19:41Z

Bara at 18:19, 27 February 2011

2011-02-27T18:19:29Z

Bara: Created page with "Literally means “abnormal cartilage development” Defective cartilage growth at the physis Usually genetic cause Occurs in cattle, dogs, sheep, pigs and cats *Leads to '''..."

2011-02-27T18:00:03Z

Created page with "*Literally means “abnormal cartilage development” *Defective cartilage growth at the physis *Usually genetic cause *Occurs in cattle, dogs, sheep, pigs and cats *Leads to '''..."

New page

*Literally means “abnormal cartilage development”
*Defective cartilage growth at the physis
*Usually genetic cause
*Occurs in cattle, dogs, sheep, pigs and cats
*Leads to '''disproportionate dwarfism''' (contrast with miniature breeds)
**Generally, growth is disproportionate because only the growth of bones which form from cartilage models is retarded – growth of other bones is normal (i.e. long bones shorter than normal)

In Dogs:
*'''Localised''' forms occur in dogs (e.g. affecting skulls of Pekingese and Bulldogs or the limbs of Dachshunds and Bassett hounds)
*Occasionally seen in immature Beagles, Poodles, Alaskan Malamutes, Scottish Deerounds and Norwegian Elkhounds

In Cattle:
*'''Dexter cattle'''
**Are heterozygous for incompletely dominant gene
**When homozygous - lethal, producing 'buldog calf'
**Usually aborted prior to seven month of pregnancy
**Also occurs in Holstein, Jerseys and Charolais
**Grossly:
***Limbs and vertebral column are short
***Domed cranium
***Protruding [[Tongue - Anatomy & Physiology|tongue]]
***Absent hard palate
***Large umbilical hernia with eventrated abdominal organs
**Histologically:
***Proliferative and hypertrophic zones in the physes are irregularly separated by fibrovascular tissue
***Chondrocytes are not properly arranged
***Irregular ossification and mineralisation

*'''Telemark type'''
**Cattle of Norwegian origin
**Also seen in Jersey cows
**Calves born alive, unable to stand and die soon after birth
**Grossly:
***Domed cranium
***Brachygnatic face
***Protruding [[Tongue - Anatomy & Physiology|tongue]]
***Cleft palate
***Short neck and limbs

*'''Brachycephalic 'Snorter' type'''
**Hereford and Aberdeen Angus
**Show nasal dyspnoea and chronic rumenal tympany
**Grossly:
***Short, broad head
***Prominent, laterally displaced eyes
***Short and compressed vertebral column
***Distal long bones shorter than proximal
**Histologically:
**Physes appear normal
**Pallisading chondrocytes fewer in number
**Less hypertrophy

In Sheep:
*'''Ancon type'''
**Short limbs due to premature closure of growth plates
**Now rare
*'''Spider lamb'''
**Hereditary (autosomal recessive) in Suffolk and Hampshire breeds in North America
**Long, thin, angular limbs
**May be born alive or dead, aborted or develop symptoms within a month of birth
**Grossly:
***Fine bones, poor musculature, small heads, scoliosis
**Histologically:
***Abnormal centres of [[Bone & Cartilage Development - Anatomy & Physiology|endochondral ossification]]
***Nodular cartilage hypertrophy

In Pigs:
*Occurs in Danish Landrace
*Autosomal recesive inheritance
*Dwarfs with short legs, forelegs shorter than hind legs
*Abnormal movement is noticable at weaning
*Sequel is [[Joints Degenerative - Pathology#Degenerative joint disease (DJD)|arthrosis]]

[[Category:Bones - Developmental Pathology]]

@@ Line 13: / Line 13: @@
 *'''Dexter cattle'''
 **Are heterozygous for incompletely dominant gene
-**When homozygous - lethal, producing ''''buldog calf''''
+**When homozygous - lethal, producing ''''bulldog calf''''
 *** A well recognised deformation in Dexter calves.
 *** Related to defective cartilage matrix and abnormal ossification.

@@ Line 73: / Line 73: @@
 *Dwarfs with short legs, forelegs shorter than hind legs
 *Abnormal movement is noticable at weaning
-*Sequel is [[Joints Degenerative - Pathology#Degenerative joint disease (DJD)|arthrosis]]
+*Sequel is [[Degenerative Joint Disease|arthrosis]]
 [[Category:Bones - Developmental Pathology]]

Chondrodysplasia - Revision history

Bara at 16:03, 3 March 2011

Bara at 18:19, 27 February 2011

Bara at 18:19, 27 February 2011

Bara: Created page with "*Literally means “abnormal cartilage development” *Defective cartilage growth at the physis *Usually genetic cause *Occurs in cattle, dogs, sheep, pigs and cats *Leads to '''..."

Bara: Created page with "Literally means “abnormal cartilage development” Defective cartilage growth at the physis Usually genetic cause Occurs in cattle, dogs, sheep, pigs and cats *Leads to '''..."