Donkey Biochemistry - Revision history

Lizhazellsmith at 11:57, 23 December 2016

2016-12-23T11:57:39Z

Lizhazellsmith at 11:47, 23 December 2016

2016-12-23T11:47:10Z

Lizhazellsmith at 12:41, 9 November 2016

2016-11-09T12:41:21Z

Lizhazellsmith at 15:22, 4 November 2016

2016-11-04T15:22:49Z

Lizhazellsmith at 15:00, 4 November 2016

2016-11-04T15:00:07Z

Lizhazellsmith at 14:53, 4 November 2016

2016-11-04T14:53:56Z

Lizhazellsmith at 12:57, 4 November 2016

2016-11-04T12:57:43Z

Lizhazellsmith at 12:56, 4 November 2016

2016-11-04T12:56:30Z

Bara at 22:23, 23 October 2010

2010-10-23T22:23:54Z

Bara: Protected "Donkey Biochemistry" ([edit=Donkey] (indefinite) [move=Donkey] (indefinite))

2010-10-23T22:20:35Z

Protected "Donkey Biochemistry" ([edit=Donkey] (indefinite) [move=Donkey] (indefinite))

@@ Line 67: / Line 67: @@
 |38
 |(32 - 48)
 |-
 !align="left" bgcolor="#F2F2F2"|Creat μmol/l
 |bgcolor="#F2F2F2"|87
 |bgcolor="#F2F2F2"|(53 - 118)
-|bgcolor="#F2F2F2"|
+|bgcolor="#F2F2F2"| '''Creatinine.''' Produced in the body by muscle breakdown and filtered by the kidneys. A marker of renal function. In equines creatinine is the most reliable marker of glomerular filtration rate as tubular reabsorption is minimal. Renal tubular damage and reduced glomerular filtration rates will result in increased creatinine.
 |-
 !align="left"|Urea mmol/l
 |3.2
 |(1.5 – 5.2)
 |-
 !align="left" bgcolor="#F2F2F2"|Amylase iu/l

@@ Line 62: / Line 62: @@
 |bgcolor="#F2F2F2"|(22 - 32)
 |bgcolor="#F2F2F2"|'''Albumin.''' Hypoalbuminaemia may be seen with decreased synthesis resulting from intestinal malabsorption, malnutrition, chronic inflammatory disease and chronic liver disease. It is lost in renal disease and gastrointestinal disease.
-Hypoalbuminaemia occurs only in severe dehydration.
+Hyperalbuminaemia occurs only in severe dehydration.
 |-
 !align="left"|Glob g/l

@@ Line 121: / Line 121: @@
 |-
 |}
-Burden, F.A., Getachew, M., Hazell-Smith, E., Patrick, V., Trawford, R., Brooks Brownlie, H. (2015). [http://onlinelibrary.wiley.com/doi/10.1111/eve.12512/pdf Reference intervals for biochemical and haematological parameters in mature domestic donkeys (Equus asinus) in the UK.] ''Equine Veterinary Education'', '''28''' (3), 134-139
+Burden, F.A., Hazell-Smith, E., Mulugeta, G.,  Patrick, V., Trawford, R., Brooks Brownlie, H. (2015). [http://onlinelibrary.wiley.com/doi/10.1111/eve.12512/pdf Reference intervals for biochemical and haematological parameters in mature domestic donkeys (Equus asinus) in the UK.] ''Equine Veterinary Education'', '''28''' (3), 134-139

@@ Line 121: / Line 121: @@
 |-
 |}
-Burden, F.A., Getachew, M., Hazell-Smith, E., Patrick, V., Trawford, R., Brooks Brownlie, H. (2015). Reference intervals for biochemical and haematological parameters in mature domestic donkeys (Equus asinus) in the UK. ''Equine Veterinary Education'', '''28''' (3), 134-139
+Burden, F.A., Getachew, M., Hazell-Smith, E., Patrick, V., Trawford, R., Brooks Brownlie, H. (2015). [http://onlinelibrary.wiley.com/doi/10.1111/eve.12512/pdf Reference intervals for biochemical and haematological parameters in mature domestic donkeys (Equus asinus) in the UK.] ''Equine Veterinary Education'', '''28''' (3), 134-139

@@ Line 74: / Line 74: @@
 |-
 !align="left"|Urea mmol/l
-|302
+|3.2
 |(1.5 – 5.2)
 |-

@@ Line 64: / Line 64: @@
 Hypoalbuminaemia occurs only in severe dehydration.
 |-
-!align="left"|Amylase iu/l
+!align="left"|Glob g/l
-|4
+|38
-|(1 - 10.6)
+|(32 - 48)
 |Elevations occur with pancreatitis.
 |-
-!align="left" bgcolor="#F2F2F2"|Lipase iu/l
+!align="left" bgcolor="#F2F2F2"|Glucose mmol/l
-|bgcolor="#F2F2F2"|12.9
+| bgcolor="#F2F2F2"|4.43
-|bgcolor="#F2F2F2"|(7.8 - 27.3)
+| bgcolor="#F2F2F2"| (3.9 - 4.7)
-|bgcolor="#F2F2F2"|Elevations occur with pancreatitis.
+| bgcolor="#F2F2F2"|Blood '''glucose''' concentration is related to diet, insulin, glucagon and body requirement. Prolonged hyperglycaemia is seen in hyperadrenocorticism and pituitary adenoma. A transient hyperglycaemia occurs postprandially and with stress. Hypoglycaemia can be seen in liver failure, septicaemia, malabsorption and starvation. Can be used for the diagnosis of intestinal  malabsorption. False reductions in serum glucose may occur in vitro due to glycolysis by erythrocytes.
 |-
-!align="left"|Glucose mmol/l
+!align="left" |Calcium mmol/l
-|4.43
+|3
-|(3.9 - 4.7)
+|(2.2 – 3.4)
-|Blood '''glucose''' concentration is related to diet, insulin, glucagon and body requirement. Prolonged hyperglycaemia is seen in hyperadrenocorticism and pituitary adenoma. A transient hyperglycaemia occurs postprandially and with stress. Hypoglycaemia can be seen in liver failure, septicaemia, malabsorption and starvation. Can be used for the diagnosis of intestinal  malabsorption. False reductions in serum glucose may occur in vitro due to glycolysis by erythrocytes.
+|Elevations occur with pancreatitis.
 |-
 !align="left" bgcolor="#F2F2F2"|Na mmol/l
 |bgcolor="#F2F2F2"|133
@@ Line 103: / Line 122: @@
 |}
 Burden, F.A., Getachew, M., Hazell-Smith, E., Patrick, V., Trawford, R., Brooks Brownlie, H. (2015). Reference intervals for biochemical and haematological parameters in mature domestic donkeys (Equus asinus) in the UK. ''Equine Veterinary Education'', '''28''' (3), 134-139
 {{infotable

@@ Line 14: / Line 14: @@
 |-
 !align="left"|Trig mmol/l
-|1
+|1.4
-|(0.2 - 4.3)
+|(0.6 - 2.8)
 |'''Triglyceride'''. Elevations occur in hyperlipaemia.
 |-
-!align="left" bgcolor="#F2F2F2"|CPK IU/l
+!align="left" bgcolor="#F2F2F2"|CPK iu/l
-|bgcolor="#F2F2F2"|97
+|bgcolor="#F2F2F2"|208
-|bgcolor="#F2F2F2"|(36 - 360)
+|bgcolor="#F2F2F2"|(128 - 525)
 |bgcolor="#F2F2F2"|'''Creatine phosphokinase'''. Elevations seen in the presence of acute myopathy: Skeletal myopathy, cardiac myopathy and brain pathology.
 |-
-!align="left"|AST IU/l
+!align="left"|AST iu/l
-|220
+|362
-|(11 - 402)
+|(238 - 536)
 |'''Aspartate aminotransferase'''. Elevations seen with acute myopathy or hepatopathy. Elevations in combination with CPK indicate that muscle is the most likely source.
 |-
-!align="left" bgcolor="#F2F2F2"|GGT IU/l
+!align="left" bgcolor="#F2F2F2"|GGT iu/l
-|bgcolor="#F2F2F2"|29
+|bgcolor="#F2F2F2"|24
-|bgcolor="#F2F2F2"|(13 - 79)
+|bgcolor="#F2F2F2"|(14 - 69)
 |bgcolor="#F2F2F2"|'''Gamma glutamyl transferase.''' Found in hepatocyte and biliary cell membranes, pancreas and the kidney. Elevations are seen in acute hepatitis, chronic liver cirrhosis, chronic pyrrolizidine alkaloid toxicity and rarely with  pancreatitis.
 |-
-!align="left"|GLDH IU/l
+!align="left"|GLDH iu/l
-|2.9
+|2.5
-|(0.7 - 14.6)
+|(1.2 - 8.2)
 |'''Glutamate dehydrogenase.''' A mitochondrial enzyme; elevations seen with acute hepatocellular damage, and sometimes seen in skin conditions and enteropathy.
 |-
-!align="left" bgcolor="#F2F2F2"|ALP IU/l
+!align="left" bgcolor="#F2F2F2"|ALP iu/l
-|bgcolor="#F2F2F2"|265
+|bgcolor="#F2F2F2"|152
-|bgcolor="#F2F2F2"|(110 - 563)
+|bgcolor="#F2F2F2"|(98 - 252)
 |bgcolor="#F2F2F2"|'''Alkaline phosphatase.''' A brush border enzyme; elevations are seen in chronic biliary obstructive liver pathology, abnormalities of bone metabolism and intestinal disease.
 |-
-!align="left"|Bile acids
+!align="left"|Bile acids μmol/l
-|<20
+|10
-|.
+|(2.6 - 18.6)
 |Elevations occur with impaired hepatobiliary function such as cholelithiasis, acute hepatitis, chronic liver cirrhosis, and chronic pyrrolizidine alkaloid toxicity. May sometimes be seen with hyperlipaemia, malignant lymphoma and toxic myopathy.
 |-
 !align="left" bgcolor="#F2F2F2"|Tbil μmol/l
-|bgcolor="#F2F2F2"|2.7
+|bgcolor="#F2F2F2"|1.6
-|bgcolor="#F2F2F2"|(1.4 - 7.7)
+|bgcolor="#F2F2F2"|(0.1 - 3.7)
 |bgcolor="#F2F2F2"|'''Total bilirubin.''' Increases may be difficult to interpret without clinical disease. Levels can increase with anorexia and intestinal malfunction.
 |-
 !align="left"|TP g/l
-|70
+|65
-|(58 - 82)
+|(58 - 76)
 |'''Total protein'''. Composed of albumin and globulins. Elevations seen with dehydration, inflammation and myeloma. Decreases may be seen with renal and gastrointestinal disease (loss), hepatic disease and starvation (reduced production).
 |-
 !align="left" bgcolor="#F2F2F2"|Alb g/l
-|bgcolor="#F2F2F2"|28
+|bgcolor="#F2F2F2"|26
-|bgcolor="#F2F2F2"|(20 - 34)
+|bgcolor="#F2F2F2"|(22 - 32)
 |bgcolor="#F2F2F2"|'''Albumin.''' Hypoalbuminaemia may be seen with decreased synthesis resulting from intestinal malabsorption, malnutrition, chronic inflammatory disease and chronic liver disease. It is lost in renal disease and gastrointestinal disease.
 Hypoalbuminaemia occurs only in severe dehydration.
 |-
-!align="left"|Amylase IU/l
+!align="left"|Amylase iu/l
-|8
+|4
-|(0 - 24)
+|(1 - 10.6)
 |Elevations occur with pancreatitis.
 |-
-!align="left" bgcolor="#F2F2F2"|Lipase IU/l
+!align="left" bgcolor="#F2F2F2"|Lipase iu/l
-|bgcolor="#F2F2F2"|16
+|bgcolor="#F2F2F2"|12.9
-|bgcolor="#F2F2F2"|(1 - 66)
+|bgcolor="#F2F2F2"|(7.8 - 27.3)
 |bgcolor="#F2F2F2"|Elevations occur with pancreatitis.
 |-
 !align="left"|Glucose mmol/l
-|.
+|4.43
-|(3.1 - 5)
+|(3.9 - 4.7)
 |Blood '''glucose''' concentration is related to diet, insulin, glucagon and body requirement. Prolonged hyperglycaemia is seen in hyperadrenocorticism and pituitary adenoma. A transient hyperglycaemia occurs postprandially and with stress. Hypoglycaemia can be seen in liver failure, septicaemia, malabsorption and starvation. Can be used for the diagnosis of intestinal  malabsorption. False reductions in serum glucose may occur in vitro due to glycolysis by erythrocytes.
 |-
 !align="left" bgcolor="#F2F2F2"|Na mmol/l
-|bgcolor="#F2F2F2"|.
+|bgcolor="#F2F2F2"|133
-|bgcolor="#F2F2F2"|(130 - 149)
+|bgcolor="#F2F2F2"|(128 - 138)
 |bgcolor="#F2F2F2"|'''Sodium.''' Hypernatremia may be seen in dehydration and salt poisoning. Hyponatraemia can occur with  diarrhoea, adrenal insufficiency, renal disease, excessive sweating or sequestration of fluid. Hyponatraemia with hyperkalemia may
 occur in uroperitoneum and hypoadrenocorticism.
 |-
 !align="left"|K mmol/l
-|.
+|4.3
-|(2.8 - 4.3)
+|(3.2 - 5.1)
 |Serum '''potassium''' is not a reliable indicator of total body potassium as concentrations vary between the intracellular and extracellular fluid, and values should be interpreted in conjunction with blood pH. Hyperkalemia can occur with tissue necrosis, strenuous exercise, acidemia, uroperitoneum, hypoadrenocorticism and artefactually with erythrocyte haemolysis. Hypokalemia can occur with anorexia, excess sweating, urinary and gastrointestinal loss.
 |-
 !align="left" bgcolor="#F2F2F2"|Cl mmol/l
-|bgcolor="#F2F2F2"|.
+|bgcolor="#F2F2F2"|102
-|bgcolor="#F2F2F2"|(95 - 108)
+|bgcolor="#F2F2F2"|(96 - 106)
 |bgcolor="#F2F2F2"|Changes in '''chloride''' concentration may accompany changes in sodium concentration, and vary inversely with bicarbonate concentration. Hypochloridemia can result from loss of gastric HCl ''e.g.'' in obstruction of the small intestine, and
 anterior enteritis. It may also occur with loss of colonic Cl ''e.g.'' in colitis.
 |-
 !align="left"|Chol mmol/l
-|.
+|2.0
-|(1 - 3)
+|(1.4 - 2.9)
 |Elevations in '''cholesterol''' can occur if there is abnormal lipid metabolism and hyperlipaemia.
 |-

@@ Line 104: / Line 104: @@
 * Svendsen, E.D., Duncan, J. and Hadrill, D. (2008) ''The Professional Handbook of the Donkey'', 4th edition, Whittet Books, Appendix 1
 [[Category:Biochemistry Reference Ranges]]
 [[Category:WikiNormals]]

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