Erythrocytes - Revision history

Fiorecastro at 16:30, 5 January 2023

2023-01-05T16:30:33Z

Bara: /* Function */

2015-05-19T12:31:55Z

Function

Bara at 19:50, 24 January 2013

2013-01-24T19:50:54Z

A.allison at 14:57, 21 April 2012

2012-04-21T14:57:43Z

A.allison at 14:57, 21 April 2012

2012-04-21T14:57:32Z

Ctrace: /* Breakdown */

2011-05-24T11:17:23Z

Breakdown

Kate English at 12:51, 16 February 2011

2011-02-16T12:51:12Z

Suzannah.stacey: /* Breakdown */

2010-09-22T16:43:54Z

Breakdown

Suzannah.stacey: /* Life Span */

2010-09-22T16:41:08Z

Life Span

Suzannah.stacey: /* Figures */

2010-09-22T16:35:06Z

Figures

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-{{OpenPagesTop}}
 [[Image:LH Erythrocyte Histology.jpg|thumb|right|150px|<p>'''Erythrocytes'''</p>]]
 Also known as '''''red blood cells (RBCs)
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-{{OpenPages}}
+==Webinars==
 [[Category:Blood Cells]] [[Category:Kate English reviewing]]

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 ==Function==
-RBCs contain haemoglobin, an oxygen binding protein that is responsible for the transport of oxygen from the lungs to tissues, and the transportation of carbon dioxide from the tissues to the lungs for elimination.
+RBCs contain '''haemoglobin''', an oxygen binding protein that is responsible for the transport of oxygen from the lungs to tissues, and the transportation of carbon dioxide from the tissues to the lungs for elimination.
 [[Image:LH Hb Animation.gif|thumb|right|250px|<p>Blue(α) & orange(β) are globin chains</p><p>Red objects represent haem groups</p>]]
 <p>Haemoglobin (Hb) is a metalloprotein that binds oxygen reversibly and accounts for almost all of the protein in the erythrocyte.</p>

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 [[Image:LH Erythrocyte Histology.jpg|thumb|right|150px|<p>'''Erythrocytes'''</p>]]
 Also known as '''''red blood cells (RBCs)
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 |powerpoints = [[Blood and Haemopoiesis resource|Tutorial about histology of blood cells]]
 }}
 [[Category:Blood Cells]] [[Category:Kate English reviewing]]

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-[[Image:LH Erythrocyte Histology.jpg|thumb|right|150px|<p>'''Erythrocytes'''</p><sup> ©RVC 2008</sup>]]
+[[Image:LH Erythrocyte Histology.jpg|thumb|right|150px|<p>'''Erythrocytes'''</p>]]
 Also known as '''''red blood cells (RBCs)
 <p>Erythrocytes deliver oxygen to, and remove carbon dioxide from tissues.</p>

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 Erythrocytes are derived from the stem cell ([[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]]) and formed in a process known as [[Erythropoiesis|erythropoiesis]].
 ==Erythrocyte Structure==
-[[Image:LH_Avian_Erythrocyte_Histology.jpg|thumb|right|150px|<p>'''Avian Erythrocytes'''</p>.<sup>©RVC 2008</sup>]]
+[[Image:LH_Avian_Erythrocyte_Histology.jpg|thumb|right|150px|<p>'''Avian Erythrocytes'''</p>]]
 ===Mammals===
 <p>Erythrocytes are small (4-8µm), circular, anucleate biconcave cells that lack organelles. </p>

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 [[Image:Haem Breakdown.jpg|center|thumb|375px|<div style="text-align: center;"><p>'''Haem breakdown pathway'''</p><sup>©Nottingham Uni 2008</sup></div>]]
 <br>
 [[Category:Blood Cells]] [[Category:Kate English reviewing]]

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 Around 90% of erythrocytes are phagocytised by [[Macrophages|macrophages]] in the [[Liver - Anatomy & Physiology|liver]], [[Spleen - Anatomy & Physiology|spleen]] and [[Bone Marrow - Anatomy & Physiology|bone marrow]], with the other 10% breaking down in circulation.
-Following phagocytosis, haemoglobin is broken down into haem and globin. Globin, a protein, is hydrolysed into amino acids while the haem is transformed into biliverdin and then into bilirubin before being excreted into the blood stream bound to albumin. In the [[Liver - Anatomy & Physiology|liver]] it is conjugated and excreted into bile which in turn is excreted into the [[Alimentary System Overview - Anatomy & Physiology#Stomach|gut]]. The iron from haem is either stored as insoluble ferritin in the [[Liver - Anatomy & Physiology|liver]] (hepatocytes and [[Macrophages|macrophages]]) or is directly transported to the [[Bone Marrow - Anatomy & Physiology|bone marrow]] by transferring for reuse in [[Erythropoiesis|erythropoiesis]].
+Following phagocytosis, haemoglobin is broken down into haem and globin. Globin, a protein, is hydrolysed into amino acids while the haem is transformed into biliverdin and then into bilirubin before being excreted into the blood stream bound to albumin. In the [[Liver - Anatomy & Physiology|liver]] it is conjugated and excreted into bile which in turn is excreted into the [[Alimentary System Overview - Anatomy & Physiology#Stomach|gastro-intestinal system]]. The iron from haem is either stored as insoluble ferritin in the [[Liver - Anatomy & Physiology|liver]] (in hepatocytes and [[Macrophages|macrophages]]) or it is directly transported to the [[Bone Marrow - Anatomy & Physiology|bone marrow]] for reuse in [[Erythropoiesis|erythropoiesis]].
-[[Image:Haem Breakdown.jpg|center|thumb|350px|<div style="text-align: center;"><p>'''Haem breakdown pathway'''</p><sup>©Nottingham Uni 2008</sup></div>]]
+[[Image:Haem Breakdown.jpg|center|thumb|375px|<div style="text-align: center;"><p>'''Haem breakdown pathway'''</p><sup>©Nottingham Uni 2008</sup></div>]]
 <br>
 [[Category:Blood Cells]]

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 Erythrocytes have a limited life span and as they age their membranes become more fragile leading to a loss of function and swelling. Damage occurs as the fragile cells pass through narrow capillaries which occurs particularly in the [[Spleen - Anatomy & Physiology#Erythrocytes & Platelets|spleen]]. Ageing also causes sialic acid to be lost from the membrane and this exposes galactose moieties leading to phagocytosis.
 ===Life Span===
-The life span of the erythrocyte varies from 70-160 days in the domestic species although the life span is often shorter in the juvenile animals (e.g. calves and lambs) than the adult. Small animal’s erythrocytes have a shorter life span than the larger domestic species.
+The life span of the erythrocyte varies from 70-160 days in domestic species although the life span is often shorter in juvenile animals (e.g. calves and lambs) compared to adult animals. Erythrocytes in small animals have a shorter life span than in the larger domestic species.
 {| border="0" cellpadding="5" cellspacing="1"
 !style="color:black;background-color:#FFC1C1;" colspan="7"|Life span (days)

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 <p> There are three types of haemoglobin: embryonic, foetal and adult. Embryonic is present in the early stages of foetal development. Foetal haemoglobin has a higher affinity for oxygen than adult haemoglobin and is replaced by adult haemoglobin shortly after birth. Dogs do not have foetal or embryonic haemoglobin. Horses do not have embryonic haemoglobin and their foetal haemoglobin is structurally identical to adult haemoglobin and as such some would say that there is no foetal haemoglobin. Pig (and horse) foetal haemoglobin has the same affinity for oxygen as their adult haemoglobin.</p>
-====Figures====
+====Chemistry====
 <p>
 *One gram of haemoglobin binds 1.34g of oxygen.