Feline Leukemia Virus - Revision history

Bara: Redirected page to Feline Leukaemia Virus

2010-08-12T14:10:49Z

Redirected page to Feline Leukaemia Virus

Bara at 13:19, 11 August 2010

2010-08-11T13:19:28Z

Bara: Text replace - "Category:To_Do_-_Viruses" to "Category:To_Do_-_Clinical/Viruses"

2010-07-30T12:20:36Z

Text replace - "Category:To_Do_-_Viruses" to "Category:To_Do_-_Clinical/Viruses"

Suzannah.stacey at 07:23, 23 July 2010

2010-07-23T07:23:10Z

Suzannah.stacey at 07:22, 23 July 2010

2010-07-23T07:22:07Z

Bara at 22:56, 26 June 2010

2010-06-26T22:56:45Z

Bara at 12:03, 23 May 2010

2010-05-23T12:03:46Z

Bara at 12:03, 23 May 2010

2010-05-23T12:03:14Z

Bara: moved Feline Leukemia Virus (FeLV) to Feline Leukemia Virus

2010-05-23T12:02:57Z

moved Feline Leukemia Virus (FeLV) to Feline Leukemia Virus

Bepocock: /* Antigenicity */

2008-10-18T19:15:40Z

Antigenicity

← Older revision		Revision as of 14:10, 12 August 2010
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−	Feline ~~Leukemia Virus is commonly abbreviated to FeLV~~	+	#REDIRECT[[Feline Leukaemia Virus]]
−
−	~~====Antigenicity====~~
−	*Main envelope protein: gp70
−	*3 antigenic subgroups:
−	*Group A
−	**is transmitted between cats
−	**is monotypic: one vaccine covers all isolates
−	**causes '''lymphosarcoma'''
−	*Group B:
−	**is recombinant with transmissible FeLV-A
−	**increases the chance of '''thymic tumors'''
−	*Group C:
−	**is a mutant of A
−	**isolates are rare, and occur as A+C mixtures
−	**increases chances of '''anemia'''
−
−	~~====Pathogenesis====~~
−	*FeLV is the "disease of friends": transmission usually occurs through '''mutual grooming'''
−	*From the oropharynx, virus spreads to most tissues in the body to replicate, notably:
−	**Bone marrow
−	**Thymus
−	**Salivary glands
−	**Reproductive tract
−	*Most kittens but only 30% of adults become '''viremic''' for life without producing antibody
−	**20% of viremic cats die of tumors
−	**30% of viremic cats die of FeLV-associated disease
−	**80% die within three years of exposure
−	*30% of adults exposed become '''latently infected''' and can become viremic when immunosuppressed
−	*40% of exposed adults remain healthy and develop Ab and CD8+ Tcells after clearing the virus, without becoming reinfected or silent carriers
−
−	~~Clinical Signs:~~
−	*'''Leukemia'''
−	*'''Multicentric lymphosarcoma''': B or T cell tumors, which may be palpable as enlarged lymph nodes (particularly mesenteric)
−	*'''Thymic lymphosarcoma''': T cell tumors, with only the thymus enlarged
−	**Results in dyspnoea
−	**Confirmed by radiography
−	*'''Alimentary lymphosarcoma''': B cell tumors of the Peyer's patches
−
−	~~FeLV-associated disease:~~
−	*'''Immunodepression''' causing secondary disease
−	*'''Reproductive failure''': FeLV crosses the placenta, causing fetal resorption or viremic kittens with thymic aplasia
−
−	~~====Epidemiology====~~
−	*Vertical transmission of FeLV-A from mother to kittens either via placenta, grooming, or milk
−	*Horizontal transmission occurs via saliva during mutual grooming
−	*Recovery linked to age and presence of maternal antibody
−	*Particular concern for intensively bred cats because of crowding, etc.
−
−	~~====Diagnosis====~~
−	*FeLV should be suspect in any cat with '''recurrent bacterial infections''', '''anemia''' or '''weight loss'''
−	*'''ELISA''' for '''Antigen''' (capsid protein p27 or envelope protein gp70)
−	*'''Immunochromatography''' is now trusted as ELISA testing can give false positives
−	*'''Virus ~~isolation''' from heparinised blood can now be performed to confirm a positive diagnosis~~
−
−	~~====Control====~~
−	*Antigen positive sick cats should be destroyed
−	*Healthy positive cats should have diagnosis confirmed
−	*Vaccination:
−	**Should take place once antigen-negative status has been determined
−	**'''Leukogen''': Subunit vaccine (using envelope protein gp70) produced in ''E. coli'' mixed with Quill-A and alhydrogel
−	**Others include inactivated virus and canarypox recombinants, but all MUST include FeLV-A
−	~~[[Category:Mammalian Type C retrovirus ]][[Category:Cat]]~~
−	~~[[Category:To_Do_-_Clinical/Viruses]]~~
−	~~[[Category:To Do - Blood]][[Category:Lymphoreticular and Haemopoietic Diseases~~]]

← Older revision		Revision as of 13:19, 11 August 2010
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	[[Category:Mammalian Type C retrovirus ]][[Category:Cat]]		[[Category:Mammalian Type C retrovirus ]][[Category:Cat]]
	[[Category:To_Do_-_Clinical/Viruses]]		[[Category:To_Do_-_Clinical/Viruses]]
		+	[[Category:To Do - Blood]][[Category:Lymphoreticular and Haemopoietic Diseases]]

@@ Line 62: / Line 62: @@
 **Others include inactivated virus and canarypox recombinants, but all MUST include FeLV-A
 [[Category:Mammalian Type C retrovirus ]][[Category:Cat]]
-[[Category:To_Do_-_Viruses]]
+[[Category:To_Do_-_Clinical/Viruses]]

← Older revision		Revision as of 07:23, 23 July 2010
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−		+	Feline Leukemia Virus is commonly abbreviated to FeLV
−	FeLV

	====Antigenicity====		====Antigenicity====

← Older revision		Revision as of 07:22, 23 July 2010
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−	~~{{unfinished}}~~	+
	FeLV		FeLV

← Older revision		Revision as of 22:56, 26 June 2010
Line 63:		Line 63:
	**Others include inactivated virus and canarypox recombinants, but all MUST include FeLV-A		**Others include inactivated virus and canarypox recombinants, but all MUST include FeLV-A
	[[Category:Mammalian Type C retrovirus ]][[Category:Cat]]		[[Category:Mammalian Type C retrovirus ]][[Category:Cat]]
		+	[[Category:To_Do_-_Viruses]]

← Older revision		Revision as of 12:03, 23 May 2010
Line 62:		Line 62:
	**'''Leukogen''': Subunit vaccine (using envelope protein gp70) produced in ''E. coli'' mixed with Quill-A and alhydrogel		**'''Leukogen''': Subunit vaccine (using envelope protein gp70) produced in ''E. coli'' mixed with Quill-A and alhydrogel
	**Others include inactivated virus and canarypox recombinants, but all MUST include FeLV-A		**Others include inactivated virus and canarypox recombinants, but all MUST include FeLV-A
		+	[[Category:Mammalian Type C retrovirus ]][[Category:Cat]]

@@ Line 1: / Line 1: @@
 {{unfinished}}
+FeLV
 ====Antigenicity====

← Older revision	Revision as of 12:02, 23 May 2010
(No difference)

@@ Line 11: / Line 11: @@
 ====Antigenicity====
-*Main envelope protein: gp70, with 3 antigenic subgroups:
+*Main envelope protein: gp70
 *Group A
 **is transmitted between cats