Feline Medicine Q&A 02 - Revision history

Bara at 15:58, 30 September 2011

2011-09-30T15:58:42Z

Ggaitskell at 15:00, 29 September 2011

2011-09-29T15:00:00Z

Bara at 15:44, 7 September 2011

2011-09-07T15:44:35Z

HelenD at 08:36, 9 August 2011

2011-08-09T08:36:04Z

Ggaitskell at 07:05, 9 August 2011

2011-08-09T07:05:56Z

Ggaitskell: Created page with "{{Template:Manson Sparkes}} 500px
'''A 6-year-old neutered male DSH cat presents with crusting lesions around the mouth (184), ears, ventral abdomen, ..."

2011-08-09T06:36:20Z

Created page with "{{Template:Manson Sparkes}} [[Image:|centre|500px]] '''A 6-year-old neutered male DSH cat presents with crusting lesions around the mouth (184), ears, ventral abdomen, ..."

New page

{{Template:Manson Sparkes}}

[[Image:|centre|500px]]

 

'''A 6-year-old neutered male DSH cat presents with crusting lesions around the mouth (184), ears, ventral abdomen, and nail beds. Histopathology reveals subcorneal pustules with acantholytic keratinocytes.'''

 

<FlashCard questions="3">
|q1=What is this disease?
|a1=
The clinical signs and histopathology in this cat are typical of pemphigus foliaceous.
|l1=
|q2=What is its cause and how should it be treated?
|a2=
Pemphigus foliaceous is an autoimmune skin disease with deposition of autoantibodies in the epidermis targeted against intercellular adhesion molecules (cadherin desmosomal glycoproteins) causing loss of cellular adhesion. 
Pemphigus foliaceous lesions most commonly affect the nose and ears, but lesions may be more generalized and affect the nail beds and foot pads. 
The primary lesions are
*vesicles,
*bullae, or
*pustules. 
However, these are relatively superficial in the epidermis and are very fragile, so are rarely seen. 
Erosions and ulcers with crusting and exudation are therefore the common signs. Cytology of exudate may be helpful diagnostically as it may reveal the rounded acantholytic keratinocytes typical of the disease, and immunofluorescence can be used to demonstrate the deposition of antibodies in the lesions.
|l2=
|q3=What is the prognosis for the cat?
|a3=
The prognosis for pemphigus foliaceous is good with most cases responding well to immunosuppressive therapy, although prolonged and sometimes life-long therapy may be required. 
Glucocorticoids are the treatment of choice (e.g. 2–4 mg/kg/day oral prednisolone, followed by a reducing dose when in remission). 
If glucocorticoid-sparing therapy is needed, chlorambucil often produces good results.
|l3=
</FlashCard>

{{#tag:imagemap|Image:Next Question.png{{!}}center{{!}}200px
rect 0 0 860 850 [[Feline Medicine Q&A 03|Feline Medicine Q&A 03]]
desc none}}
[[Category:Feline Medicine Q&A]]

← Older revision		Revision as of 15:58, 30 September 2011
Line 37:		Line 37:
	desc none}}		desc none}}
	[[Category:Feline Medicine Q&A]]		[[Category:Feline Medicine Q&A]]
−	~~[[Category:To Do - Manson]]~~

← Older revision		Revision as of 15:44, 7 September 2011
Line 37:		Line 37:
	desc none}}		desc none}}
	[[Category:Feline Medicine Q&A]]		[[Category:Feline Medicine Q&A]]
		+	[[Category:To Do - Manson]]

@@ Line 5: / Line 5: @@
 <br />
-'''A 6-year-old neutered male DSH cat presents with crusting lesions around the mouth (184), ears, ventral abdomen, and nail beds. Histopathology reveals subcorneal pustules with acantholytic keratinocytes.'''
+'''A 6-year-old neutered male DSH cat presents with crusting lesions around the mouth, ears, ventral abdomen, and nail beds. Histopathology reveals subcorneal pustules with acantholytic keratinocytes.'''
 <br />

@@ Line 1: / Line 1: @@
 {{Template:Manson Sparkes}}
-[[Image:|centre|500px]]
+[[Image:Feline Medicine 02.png|centre|500px]]
 <br />

@@ Line 13: / Line 13: @@
 |a1=
 The clinical signs and histopathology in this cat are typical of pemphigus foliaceous.
-|l1=
+|l1=Pemphigus Foliaceus
 |q2=What is its cause and how should it be treated?
 |a2=
@@ Line 24: / Line 24: @@
 However, these are relatively superficial in the epidermis and are very fragile, so are rarely seen. <br><br>
 Erosions and ulcers with crusting and exudation are therefore the common signs. Cytology of exudate may be helpful diagnostically as it may reveal the rounded acantholytic keratinocytes typical of the disease, and immunofluorescence can be used to demonstrate the deposition of antibodies in the lesions.
-|l2=
+|l2=Pemphigus Foliaceus
 |q3=What is the prognosis for the cat?
 |a3=
@@ Line 30: / Line 30: @@
 Glucocorticoids are the treatment of choice (e.g. 2–4 mg/kg/day oral prednisolone, followed by a reducing dose when in remission). <br><br>
 If glucocorticoid-sparing therapy is needed, chlorambucil often produces good results.
-|l3=
+|l3=Pemphigus Foliaceus#Treatment
 </FlashCard>