Hyperoestrogenism - Dog - Revision history

Bara at 22:02, 6 July 2011

2011-07-06T22:02:17Z

Bara at 21:52, 6 July 2011

2011-07-06T21:52:00Z

Bara: moved Hyperoestrogenism to Hyperoestrogenism - Dog

2011-07-06T21:36:58Z

moved Hyperoestrogenism to Hyperoestrogenism - Dog

HelenD at 18:09, 6 July 2011

2011-07-06T18:09:00Z

HelenD at 18:08, 6 July 2011

2011-07-06T18:08:31Z

HelenD at 18:07, 6 July 2011

2011-07-06T18:07:58Z

HelenD at 12:29, 6 July 2011

2011-07-06T12:29:50Z

Lwyasm1 at 15:26, 20 June 2011

2011-06-20T15:26:22Z

Bara at 14:21, 21 February 2011

2011-02-21T14:21:30Z

Bara at 14:20, 21 February 2011

2011-02-21T14:20:04Z

← Older revision		Revision as of 22:02, 6 July 2011
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	[[Category:Endocrine System - Pathology]]		[[Category:Endocrine System - Pathology]]
		+	[[Category:Endocrine Diseases - Dog]]
		+	[[Category:Reproductive Diseases - Dog]]
	[[Category:To Do - Reproductive]]		[[Category:To Do - Reproductive]]

@@ Line 1: / Line 1: @@
 ==Introduction==
-Hyperoestrogenism is caused by excessive levels of oestrogen in the body and has different aetiologies depending on the sex of the animal.
+Hyperoestrogenism is caused by '''excessive levels of oestrogen''' in the body and has different aetiologies depending on the sex of the animal.
-In the bitch it is usually associated with cystic ovaries or more rarely a functional ovarian tumour. These are mostly granulosa-theca cell in origin and 10-20% are malignant. It can also occur iatrogenically through the administration of oestrogens used to treat mismating and urinary incontinence.
+In the bitch it is usually associated with '''cystic ovaries''' or more rarely a functional ovarian tumour. These are mostly granulosa-theca cell in origin and 10-20% are malignant. It can also occur iatrogenically through the administration of oestrogens used to treat mismating and urinary incontinence.
-In the male dog the syndrome is associated with a Sertoli cell tumour of the testicles or a male feminising syndrome for which the cause in unknown.
+In the male dog the syndrome is associated with a [[Sertoli Cell Tumour|'''Sertoli cell tumour''']] of the testicles or a [[Male Feminising Syndrome|male feminising syndrome]] for which the cause in unknown.
-Hyperoestrogenism also occurs in the female ferret if an entire jill remains unbred for an extended period of time.
+Hyperoestrogenism is '''very rare in cats'''.
-Hyperoestrogenism is very rare in cats.
+==Clinical Signs==
-==Clinical signs==
+===Males===
-===Bitches===
+Bilaterally '''symmetrical alopecia''' and '''hyperpigmentation''', gynaecomastia, pendulous prepuce, testicular mass, prostatomegaly, '''attractiveness to other male dogs''' and loss of libido.
 ==Diagnosis==
 In all cases, history and clinical signs are suggestive.
-Haematology and biochemistry of is usually unremarkable except where '''oestrogen-induced bone marrow suppression''' occurs, in which case a '''non-regenerative anaemia''', thrombocytopenia and leucopenia are seen.
+Haematology and biochemistry of is usually unremarkable except where '''oestrogen-induced bone marrow suppression''' occurs, in which case a [[Regenerative and Non-Regenerative Anaemias|'''non-regenerative anaemia''']], [[thrombocytopenia]] and leucopenia are seen.
-Other endocrine disorders which can cause the same skin changes should be ruled out, such as hypothyroidism and hyperadrenocorticism.
+Other endocrine disorders which can cause the same skin changes should be ruled out, such as [[hypothyroidism]] and [[hyperadrenocorticism]].
 Blood oestrogens may be elevated in some dogs, however false positive and false negative results are common.
-Definitive diagnosis for bitches is by exploratory laparotomy to investigate the ovaries.
+Definitive diagnosis for bitches is by '''exploratory laparotomy''' to investigate the ovaries.
-In male dogs a mass may be palpated in the testicle.
+In male dogs a '''mass may be palpated in the testicle'''.
 ==Treatment==
-'''Ovariohysterectomy''' is the treatment of choice if an ovarian cyst or tumour is present. Radiographs of the thorax are useful prior to surgery to check for any metastases in the case of neoplasia.
+Therapy for any concurrent infections together with '''supportive care''' if oestrogen-induced myelosuppression is present (fluids and whole blood transfusion) should be provided.
-===Male dogs===
+'''Ovariohysterectomy''' is the treatment of choice if an ovarian cyst or tumour is present.
-===Jills===
+Bilateral '''castration''' is the treatment of choice for testicular tumours. Any concurrent infections of the skin or prostate gland should be assessed.
-In milder cases, '''hormone treatments''' such as proligestone can be used to induce ovulation. Signs of oestrus will abate within 10-11 days but it might take up to 4 months for the anaemia to resolve.
+Radiographs of the thorax are useful prior to surgery to '''check for any metastases''' in the case of neoplasia.
-The '''prognosis''' depends on the length of time the jill has been in oestrus and the PCV on presentation. If it is above 25% the prognosis is good. If it is below 15% the outlook is poor and intensive treatment along with multiple blood transfusions will be necessary for several months.
+==Prognosis==
-Female ferrets should not remain in heat longer than a month and ovulation should be induced by mating or hormone therapy before this. Ovariohysterectomy at 6-8 months of age is recommended for jills that are not to be bred.
+==References==
 [[Category:Endocrine System - Pathology]]
-[[Category:To Do - Manson]]
+[[Category:To Do - Reproductive]]

@@ Line 41: / Line 41: @@
 Therapy for any concurrent infections together with '''supportive care''' if oestrogen-induced myelosuppression is present (fluids and whole blood transfusion).
-'''Ovariohysterectomy''' is the treatment of choice if an ovarian cyst o tumour is present. Radiographs of the thorax are useful prior to surgery to check for any metastases in the case of neoplasia.
+'''Ovariohysterectomy''' is the treatment of choice if an ovarian cyst or tumour is present. Radiographs of the thorax are useful prior to surgery to check for any metastases in the case of neoplasia.
 Most dogs show an improvement in clinical signs within 3-6 months.

@@ Line 40: / Line 40: @@
 ===Bitches===
 Therapy for any concurrent infections together with '''supportive care''' if oestrogen-induced myelosuppression is present (fluids and whole blood transfusion).
-'''Ovariohysterectomy''' is the treatment of choice if an ovarian cyst of tumour is present. Radiographs of the thorax are useful prior to surgery to check for any metastases in the case of neoplasia.
 Most dogs show an improvement in clinical signs within 3-6 months.

@@ Line 1: / Line 1: @@
 ==Introduction==
-Hyperoestrogenism is caused by the excess production of oestrogen in the body and has different aetiologies depending on the sex of the animal.
+Hyperoestrogenism is caused by excessive levels of oestrogen in the body and has different aetiologies depending on the sex of the animal.
 In the bitch it is usually associated with cystic ovaries or more rarely a functional ovarian tumour. These are mostly granulosa-theca cell in origin and 10-20% are malignant. It can also occur iatrogenically through the administration of oestrogens used to treat mismating and urinary incontinence.
@@ Line 6: / Line 6: @@
 In the male dog the syndrome is associated with a Sertoli cell tumour of the testicles or a male feminising syndrome for which the cause in unknown.
-Hyperoestrogenism also occurs in the female ferret if she remains unbred for an extended period of time.
+Hyperoestrogenism also occurs in the female ferret if an entire jill remains unbred for an extended period of time.
 ==Clinical signs==
-Female
+===Bitches===
-===Females===
+Bilaterally symmetrical alopecia and hyperpigmentation of the perianal, perigenial and axillary areas, enlargement of the nipples and vulva, comedones and pyoderma, oestrus cycle abnormalities such as nymphomania and pyometra.
-'''''Ovarian Imbalance Type 1'''''
-Seen in adult bitches who present with alopecia and increased pigmentation round the perianal, perigenital and axillary areas.
+===Male dogs===
-Caused by:
+Bilaterally symmetrical alopecia and hyperpigmentation, gynaecomastia, pendulous prepuce, testicular mass, prostatomegaly, attractiveness to other male dogs and loss of libido.
-*Cystic ovaries.
-*Ovarian neoplasia.
+===Jills===
-===Males===
+Bilaterally symmetrical alopecia around the ventrum and tail, weight loss, pale mucous membranes, enlarged vulva and a serous or mucopurulent vaginal discharge.
-Dogs present with bilaterally symmetric alopecia, similar hyperpigmentation to that seen with female dogs with ovarian imbalance, loss of libido and gynaecomastia.   The dogs become attractive to other male dogs.
-Caused by:
+==Diagnosis==
-*[[Sertoli Cell Tumour|Sertoli cell tumour]].
+===Dogs===
-*[[Male Feminising Syndrome|Male feminising syndrome]].
+In all cases, history and clinical signs are suggestive.
 [[Category:Endocrine System - Pathology]]
 [[Category:To Do - Manson]]
 [[Category:To Do - Helen]]

← Older revision	Revision as of 21:36, 6 July 2011
(No difference)

← Older revision		Revision as of 15:26, 20 June 2011
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	[[Category:Endocrine System - Pathology]]		[[Category:Endocrine System - Pathology]]
		+	[[Category:To Do - Manson]]