Bara: Created page with "May be of dietary or iatrogenic origin (has narrow safety margin) Key features are hypercalcaemia with metastatic calcification of soft tissues *'''Acute poisoning''' **In dogs..."

2011-02-27T18:56:04Z

Created page with "*May be of dietary or iatrogenic origin (has narrow safety margin) *Key features are hypercalcaemia with metastatic calcification of soft tissues *'''Acute poisoning''' **In dogs..."

New page

*May be of dietary or iatrogenic origin (has narrow safety margin)
*Key features are hypercalcaemia with metastatic calcification of soft tissues
*'''Acute poisoning'''
**In dogs and cats often from rodenticides containing cholecalciferol
**Grossly:
***Gastrointestinal haemorrhage
***Foci of [[Myocardial Mineralisation|myocardial discoloration]]
**Microscopically:
***Mucosal haemorrhage
***Necrosis of crypts
***Focal myocardial necrosis
***Mineralisation of intestinal mucosa, [[Arterial Calcification#Medial calcification|blood vessel walls]], [[Pulmonary Calcification|lungs]] and kidneys
*'''Chronic poisoning'''
**Grossly:
***Intense [[Bones - Anatomy & Physiology|osteoclastic activity]] -> active resorption of bone, especially [[Bones - Anatomy & Physiology|trabecular]]
**Microscopically:
***Excessive production of [[Bones - Anatomy & Physiology|osteoid]] - appears both eosinophilic and basophilic in different places
***Marrow cavity may be obliterated
***Mineralisation of soft tissues, especially [[Arterial Calcification|blood vessel walls]]
**Due to inhibition of [[Calcium|Parathyroid Hormone (PTH)|PTH]] and increase of [[Calcium#Calcitonin|calcitonin]]

[[Category:Bones - Metabolic Pathology]]

[[Category:Toxicology]]

Hypervitaminosis D - Revision history

Bara: Created page with "*May be of dietary or iatrogenic origin (has narrow safety margin) *Key features are hypercalcaemia with metastatic calcification of soft tissues *'''Acute poisoning''' **In dogs..."

Bara: Created page with "May be of dietary or iatrogenic origin (has narrow safety margin) Key features are hypercalcaemia with metastatic calcification of soft tissues *'''Acute poisoning''' **In dogs..."