Immunoglobulin A - Revision history

Bara at 16:04, 2 July 2012

2012-07-02T16:04:55Z

Rjfrancisrvc: /* Production */

2012-05-25T08:38:39Z

Production

Bara at 15:50, 16 March 2012

2012-03-16T15:50:48Z

Bara at 14:18, 10 January 2011

2011-01-10T14:18:22Z

Aimee.e.hicks: /* Links */

2011-01-09T14:54:18Z

Links

Aimee.e.hicks at 14:53, 9 January 2011

2011-01-09T14:53:57Z

Bara at 12:19, 4 January 2011

2011-01-04T12:19:05Z

Bara at 15:06, 16 August 2010

2010-08-16T15:06:17Z

Bara at 15:05, 16 August 2010

2010-08-16T15:05:10Z

A.allison: Text replace - 'IgG' to 'IgG'

2010-06-12T16:31:57Z

Text replace - 'IgG' to 'IgG'

@@ Line 1: / Line 1: @@
 ==Overview==
 [[Image:LH sIgA.png|thumb|right|250px|<p>1 = Heavy Chain</p><p>2 = Light chain</p><p>3 = J chain</p><p>4 = Secretory component</p>]]
@@ Line 39: / Line 40: @@
 <br><br>
 {{Jim Bee 2007}}
 [[Category:Immunoglobulins]]
 [[Category:A&P Done]]

@@ Line 18: / Line 18: @@
 ==Production==
-IgA is preferentially produced at mucosal surfaces by plasma cells. Il-4 produced by T cells (Th2) and mast cells, signals B cells to differentiate into plasma cells. Il-10 and CD40 interaction with Th2 cells then causes class switching to produce IgA.
+IgA is preferentially produced at mucosal surfaces by plasma cells. IL-4 produced by T cells (T<sub>H</sub>2) and mast cells, signals B cells to differentiate into plasma cells. IL-10 and CD40 interaction with T<sub>H</sub>2 cells then causes class switching to produce IgA.
 Salivary IgA is produced by plasma cells in connective tissue around salivary glands. IgA in the alimentary system is produced by plasma cells in the lamina propria. It is the only Ig that can cross into the lumen of the alimentary tract. During lactation, the levels of IgA increase so that it becomes the predominant immunoglobulin in the milk (more than [[IgG]]). Mucosal epithelium have a “poly Ig receptor” and this bind to the J chain on the IgA, and allows IgA to travel across the cell. IgA crosses the cell in a transport vesicle and is released by exocytosis.

@@ Line 37: / Line 37: @@
 [[Immunoglobulin M|Immunoglobulin M]]
+<br><br>
 [[Category:Immunoglobulins]]
 [[Category:A&P Done]]

@@ Line 11: / Line 11: @@
 IgA is a dimeric immunoglobulin that is produced by the joining of two IgA monomers by a ‘J’ chain. Its heavy chain is type alpha(α). There are two types of IgA:
-'''Type 1''' - Non-secretory and found in blood.
+:'''Type 1''' - Non-secretory and found in blood.
+:'''Type 2''' – Secretory and secreted on mucosal surfaces.
 Only Type 2 contains the secretory component, a glycoprotein, which protects IgA from digestion and mediates its active transport across mucosal epithelium. The secretory component is added to salivary IgA by mucosal epithelial cells in the salivary glands, while in the alimentary tract, the secretory component is produced by the enterocytes.
@@ Line 40: / Line 39: @@
 [[Category:Immunoglobulins]]
-[[Category:Image Review]]
+[[Category:A&P Done]]

@@ Line 41: / Line 41: @@
 [[Category:Immunoglobulins]]
 [[Category:Image Review]]
-[[Category:To Do - AimeeHicks]]
+[[Category:To Do - AimeeHicks]][[Category:To Do - Review]]

@@ Line 1: / Line 1: @@
-{{review}}
+==Overview==
-<br>
+[[Image:LH sIgA.png|thumb|right|250px|<p>1 = Heavy Chain</p><p>2 = Light chain</p><p>3 = J chain</p><p>4 = Secretory component</p>]]
-<p>''Shortened to IgA''</p>
+[[Image:IgA.jpg|thumb|right|250px|IgA - B. Catchpole, RVC 2008]]
-[[Image:LH sIgA.png|thumb|right|150px|<p>1 = Heavy Chain</p><p>2 = Light chain</p><p>3 = J chain</p><p>4 = Secretory component</p>]]
-[[Image:IgA.jpg|thumb|right|150px|IgA - B. Catchpole, RVC 2008]]
+''Shortened to IgA''.
-<p>IgA is present at low concentrations in plasma and has minimal function inside the body. However, it is specially adapted for action at mucosal surfaces and as such is present in high concentrations in mucosal secretions and in colostrum (and milk).  In many species (dogs, cats and pigs) it is the major antibody in mucosal secretions. </p>
 ==Structure==
-<p>IgA is a dimeric immunoglobulin that is produced by the joining of two IgA monomers by a ‘J’ chain. Its heavy chain is type alpha(α). There are two types of IgA:
-*Type 1 - Non-secretory and found in blood
+IgA is a dimeric immunoglobulin that is produced by the joining of two IgA monomers by a ‘J’ chain. Its heavy chain is type alpha(α). There are two types of IgA:
-*Type 2 – Secretory and secreted on mucosal surfaces
-Only Type 2 contains the secretory component, a glycoprotein, which protects IgA from digestion and mediates its active transport across mucosal epithelium. The secretory component is added to salivary IgA by mucosal epithelial cells in the saliva glands, while in the alimentary tract the secretory component is produced by the enterocytes.</p>
+'''Type 1''' - Non-secretory and found in blood.
 ==Production==
-IgA</p><p>
+IgA is preferentially produced at mucosal surfaces by plasma cells. Il-4 produced by T cells (Th2) and mast cells, signals B cells to differentiate into plasma cells. Il-10 and CD40 interaction with Th2 cells then causes class switching to produce IgA.
-* Salivary IgA is produced by plasma cells in connective tissue around salivary glands
-*IgA in alimentary system is produced by plasma cells in the lamina propria
+Salivary IgA is produced by plasma cells in connective tissue around salivary glands. IgA in the alimentary system is produced by plasma cells in the lamina propria. It is the only Ig that can cross into the lumen of the alimentary tract. During lactation, the levels of IgA increase so that it becomes the predominant immunoglobulin in the milk (more than [[IgG]]). Mucosal epithelium have a “poly Ig receptor” and this bind to the J chain on the IgA, and allows IgA to travel across the cell. IgA crosses the cell in a transport vesicle and is released by exocytosis.
 ==Function==
-<p>
-*IgA binds to antigens and prevents agents from adhering to the epithelium, and as adhesion is a prerequisite to establishing infection, it prevents infection
+IgA binds to antigens and prevents agents from adhering to the epithelium, and as adhesion is a prerequisite to establishing infection, it prevents infection. Agents include toxins, bacteria, viruses, fungi and parasites. As IgA resists proteolytic digestion, it is able to function well in the gut, although some bacteria have proteases to overcome this resistance. IgA is a "non-inflammatory" isotype, as it does not activate [[Complement|complement]] by the classical pathway, and has no role in opsonisation. This helps to preserve the mucosal integrity and function. Ruminant mucosal [[IgG]] subclass similarly is also a poor [[Complement|complement]] activator.
-**Agents include toxins, bacteria, viruses, fungi and parasites
-*As IgA resists proteolytic digestion it is able to function well in the gut
+==Links==
-**Although some bacteria have proteases to overcome this resistance.
-*IgA is a "non-inflammatory" isotype as it does not does not activate [[Complement|complement]] by the classical pathway and has no role in opsonisation
+[[Immunoglobulins|Immunoglobulins]]
-**This helps to preserve the mucosal integrity and function
-*Ruminant mucosal [[IgG]] subclass similarly is also a poor [[Complement|complement]] activator.</p>
+[[Immunoglobulin D|Immunoglobulin D]]
-<br>
-----
+[[Immunoglobulin E|Immunoglobulin E]]
-<center><b><sup>[[Immunoglobulins|Immunoglobulins]]: [[Immunoglobulin A|Immunoglobulin A]], [[Immunoglobulin D|Immunoglobulin D]], [[Immunoglobulin E|Immunoglobulin E]], [[Immunoglobulin G|Immunoglobulin G]] & [[Immunoglobulin M|Immunoglobulin M]]</sup></b></center>
 [[Category:Immunoglobulins]]
 [[Category:Image Review]]
-[[Category:To Do - A&P]]
+[[Category:To Do - AimeeHicks]]

← Older revision		Revision as of 12:19, 4 January 2011
Line 34:		Line 34:
	[[Category:Immunoglobulins]]		[[Category:Immunoglobulins]]
	[[Category:Image Review]]		[[Category:Image Review]]
		+	[[Category:To Do - A&P]]

← Older revision		Revision as of 15:06, 16 August 2010
Line 33:		Line 33:

	[[Category:Immunoglobulins]]		[[Category:Immunoglobulins]]
		+	[[Category:Image Review]]

← Older revision		Revision as of 15:05, 16 August 2010
Line 31:		Line 31:
	----		----
	<center><b><sup>[[Immunoglobulins\|Immunoglobulins]]: [[Immunoglobulin A\|Immunoglobulin A]], [[Immunoglobulin D\|Immunoglobulin D]], [[Immunoglobulin E\|Immunoglobulin E]], [[Immunoglobulin G\|Immunoglobulin G]] & [[Immunoglobulin M\|Immunoglobulin M]]</sup></b></center>		<center><b><sup>[[Immunoglobulins\|Immunoglobulins]]: [[Immunoglobulin A\|Immunoglobulin A]], [[Immunoglobulin D\|Immunoglobulin D]], [[Immunoglobulin E\|Immunoglobulin E]], [[Immunoglobulin G\|Immunoglobulin G]] & [[Immunoglobulin M\|Immunoglobulin M]]</sup></b></center>
		+
		+	[[Category:Immunoglobulins]]