Immunoglobulin M - Revision history

Bara at 16:10, 2 July 2012

2012-07-02T16:10:53Z

Rjfrancisrvc: /* Production */

2012-05-25T10:11:18Z

Production

Rjfrancisrvc: /* Production */

2012-05-25T10:10:57Z

Production

Rjfrancisrvc: /* Production */

2012-05-25T10:10:38Z

Production

Rjfrancisrvc: /* Production */

2012-05-25T10:10:05Z

Production

Rjfrancisrvc: /* Production */

2012-05-25T10:09:54Z

Production

Rjfrancisrvc: /* Production */

2012-05-25T10:09:38Z

Production

Rjfrancisrvc at 10:09, 25 May 2012

2012-05-25T10:09:22Z

Rjfrancisrvc: /* Structure */

2012-05-25T10:02:48Z

Structure

Bara at 15:59, 16 March 2012

2012-03-16T15:59:54Z

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-{{review}}
+{{OpenPagesTop}}
 <p>''Shortened to IgM''</p>
 [[Image:LH IgM.png|thumb|150px|right|'''IgM'''<p>1 = IgM monomer</p><p>2 = Heavy chains</p><p>3 = Light chains</p><p>4 =J chain</p><p>5 = Disulfide bonds</p>]]
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 <br><br>
 {{Jim Bee 2007}}
 [[Category:Immunoglobulins]]
 [[Category:A&P Done]]

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 ==Production==
 <p>Produced by plasma cells in the spleen, bone marrow and lymph nodes. Since it is around five times larger than "normal" antibody it does not diffuse quickly or enter tissues readily and as such its concentration in extracellular fluid and lymph is very low. It does not cross the placenta even in animals with haemochorial placentas e.g. apes. </p>
-<p>IgM is the first class of antibody produced by plasma cells, with production replaced by either [[IgG]] or [[IgE]] in a process known as '''[[Immunoglobulins - Overview
+<p>IgM is the first class of antibody produced by plasma cells, with production replaced by either [[IgG]] or [[IgE]] in a process known as '''[[Immunoglobulins - Overview|class-switching]]''' once the secondary immune response is initiated. </p>
 ==Function==

@@ Line 11: / Line 11: @@
 ==Production==
 <p>Produced by plasma cells in the spleen, bone marrow and lymph nodes. Since it is around five times larger than "normal" antibody it does not diffuse quickly or enter tissues readily and as such its concentration in extracellular fluid and lymph is very low. It does not cross the placenta even in animals with haemochorial placentas e.g. apes. </p>
-<p>IgM is the first class of antibody produced by plasma cells, with production replaced by either [[IgG]] or [[IgE]] in a process known as '''[[Immunoglobulins -Overview|class-switching]]''' once the secondary immune response is initiated </p>
+<p>IgM is the first class of antibody produced by plasma cells, with production replaced by either [[IgG]] or [[IgE]] in a process known as '''[[Immunoglobulins - Overview
 ==Function==

@@ Line 11: / Line 11: @@
 ==Production==
 <p>Produced by plasma cells in the spleen, bone marrow and lymph nodes. Since it is around five times larger than "normal" antibody it does not diffuse quickly or enter tissues readily and as such its concentration in extracellular fluid and lymph is very low. It does not cross the placenta even in animals with haemochorial placentas e.g. apes. </p>
-<p>IgM is the first class of antibody produced by plasma cells, with production replaced by either [[IgG]] or [[IgE]] in a process known as '''[[Immunoglobulin-Overview|class-switching]]''' once the secondary immune response is initiated </p>
+<p>IgM is the first class of antibody produced by plasma cells, with production replaced by either [[IgG]] or [[IgE]] in a process known as '''[[Immunoglobulins -Overview|class-switching]]''' once the secondary immune response is initiated </p>
 ==Function==

@@ Line 11: / Line 11: @@
 ==Production==
 <p>Produced by plasma cells in the spleen, bone marrow and lymph nodes. Since it is around five times larger than "normal" antibody it does not diffuse quickly or enter tissues readily and as such its concentration in extracellular fluid and lymph is very low. It does not cross the placenta even in animals with haemochorial placentas e.g. apes. </p>
-<p>IgM is the first class of antibody produced by plasma cells, with production replaced by either [[IgG]] or [[IgE]] in a process known as '''[[Immunoglobulin Overview|class-switching]]''' once the secondary immune response is initiated </p>
+<p>IgM is the first class of antibody produced by plasma cells, with production replaced by either [[IgG]] or [[IgE]] in a process known as '''[[Immunoglobulin-Overview|class-switching]]''' once the secondary immune response is initiated </p>
 ==Function==

@@ Line 3: / Line 3: @@
 [[Image:LH IgM.png|thumb|150px|right|'''IgM'''<p>1 = IgM monomer</p><p>2 = Heavy chains</p><p>3 = Light chains</p><p>4 =J chain</p><p>5 = Disulfide bonds</p>]]
 [[Image:IgM.jpg|thumb|right|150px|IgM - B. Catchpole, RVC 2008]]
-<p>Is found in high concentrations in blood plasma (below [[IgG]] conc.) and is the major Ig produced during primary immune response</p>
+==Overview==
 ==Structure==
 <p>IgM is the primordial antibody and, although a monomer, is secreted as a pentamer (five monomers joined by disulphide bonds with two monomers joined by a J chain). This gives it ten identical antigen binding sites although IgM usually has relatively low affinity for its antigen. Its heavy chain is type mu (µ).</p>
 ==Production==
-<p>Produced by plasma cells in the spleen, bone marrow and lymph nodes. Since it is around five times larger than "normal" antibody it does not diffuse quickly or enter tissues readily and as such its concentration in extracellular fluid and lymph is very low.
+<p>Produced by plasma cells in the spleen, bone marrow and lymph nodes. Since it is around five times larger than "normal" antibody it does not diffuse quickly or enter tissues readily and as such its concentration in extracellular fluid and lymph is very low. It does not cross the placenta even in animals with haemochorial placentas e.g. apes. </p>
-It does not cross the placenta even in animals with haemochorial placentas e.g. apes. </p>
+<p>IgM is the first class of antibody produced by plasma cells, with production replaced by either [[IgG]] or [[IgE]] in a process known as '''[[Immunoglogulin Overview|class-switching]]''' once the secondary immune response is initiated </p>
 ==Function==
 <p>
-IgM mainly functions as a target for [[Complement|complement]] activation as well as roles in agglutination, opsonisation and virus  neutralisation.</p>
+IgM mainly functions as a target for [[Complement|complement]] activation as well as roles in agglutination, opsonisation and virus neutralisation.</p>
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