Infectious Haematopoietic Necrosis - Revision history

Bara at 14:02, 17 August 2012

2012-08-17T14:02:12Z

Bara: Text replace - "Category:CABI Expert Review Completed" to "Category:CABI Expert Review CompletedCategory:CABI AHPC Pages"

2012-04-13T15:09:55Z

Text replace - "Category:CABI Expert Review Completed" to "Category:CABI Expert Review Completed Category:CABI AHPC Pages"

Bara: /* Diagnosis */

2011-12-20T18:33:02Z

Diagnosis

Bara at 23:45, 8 December 2011

2011-12-08T23:45:37Z

Bara at 17:29, 28 November 2011

2011-11-28T17:29:14Z

Bara at 21:51, 29 September 2011

2011-09-29T21:51:04Z

HelenD at 11:50, 20 September 2011

2011-09-20T11:50:28Z

Bara: /* References */

2011-08-12T16:32:13Z

References

Bara at 22:58, 9 July 2011

2011-07-09T22:58:02Z

Lwyasm1: /* References */

2011-07-07T21:59:00Z

References

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 {{Podcasts
 |link = https://bloomsbury.mediacore.tv/podcasts/wikivet-english/infectious-haematopoietic-necrosis}}
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 |date=20 September 2011
 }}
 [[Category:CABI Expert Review Completed]][[Category:CABI AHPC Pages]] [[Category:Fish Diseases]]

← Older revision		Revision as of 15:09, 13 April 2012
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−	[[Category:CABI Expert Review Completed]] [[Category:Fish Diseases]]	+	[[Category:CABI Expert Review Completed]][[Category:CABI AHPC Pages]] [[Category:Fish Diseases]]

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 On necropsy of infected fry, the liver, '''spleen and kidneys are pale due to anaemia and ascites is common'''.  The stomach will be full of '''milky fluid''' but no food. Petechial haemorrhages are common throughout many organs. Yellowish fluid or mucus in the intestines is seen in both young and adult fish. The haematopoietic tissues of the kidney and the spleen in young fish are most severely affected, demonstrating small, pale multifocal areas with macrophage infiltration and degenerating lymphoid cells.
-A '''pathognomic '''histological feature of IHN is '''degeneration and necrosis of granular cells in the lamina propria, stratum compactum and stratum granulosum of the gastrointestinal tract'''.
+A '''pathognomonic '''histological feature of IHN is '''degeneration and necrosis of granular cells in the lamina propria, stratum compactum and stratum granulosum of the gastrointestinal tract'''.
 On cytopathology, cells appear '''balloon shaped and nuclei are displaced''' to one side.<ref>Engelking, H. M., Leong, J. C (1981) '''IHNV persistently infects chinook salmon embryo cells.''' ''Virology'', 109(1):47-58</ref>

← Older revision		Revision as of 23:45, 8 December 2011
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		+	{{Podcasts
		+	\|link = https://bloomsbury.mediacore.tv/podcasts/wikivet-english/infectious-haematopoietic-necrosis}}
	Also Known As: '''''IHN — Chinook Salmon Disease — Coleman Disease — Columbia River Sockeye Disease — Cultus Lake Virus Disease — Oregon Sockeye Disease — Sacramento River Chinook Disease — Sockeye Salmon Viral Disease'''''		Also Known As: '''''IHN — Chinook Salmon Disease — Coleman Disease — Columbia River Sockeye Disease — Cultus Lake Virus Disease — Oregon Sockeye Disease — Sacramento River Chinook Disease — Sockeye Salmon Viral Disease'''''

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 ==Clinical Signs==
-IHN causes a '''characteristic “pop-eye” appearance''' in infected fish. The '''skin and fins may be darkened and demonstrate pinpoint haemorrhages'''. Abdominal distension sometimes occurs and the gills may be pale. Casts may be visible trailing from the vent. Fish often '''behave abnormally sporadically.'''
+IHN causes a '''characteristic [[Exopthalmos - Fish|“pop-eye”]] appearance''' in infected fish. The '''skin and fins may be darkened and demonstrate pinpoint haemorrhages'''. Abdominal distension sometimes occurs and the gills may be pale. Casts may be visible trailing from the vent. Fish often '''behave abnormally sporadically.'''
 Signs can also vary with species, for example Chinook salmon often show subdermal haemorrhage immediately behind their heads<ref>Amend, D. F (1974) '''Infectious Hematopoietic Necrosis (IHN) Virus Disease'''. Fish Disease Leaflet 39. ''USA: United States Department of the Interior'', pp6</ref> and sock-eye salmon smoults have clubbed/fused lamellae.

← Older revision		Revision as of 21:51, 29 September 2011
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−	[[Category:CABI Expert Review]] [[Category:Fish Diseases]]	+	[[Category:CABI Expert Review Completed]] [[Category:Fish Diseases]]
−	~~[[Category:Expert Review Completed~~]]

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 Western North America, Continental Europe and Asia. Transmission between countries is a significant consideration due to the international trade in eggs, fry and fish.
-The virus is transmitted by '''insect, annelid and crustacean vectors'''. It is shed by infected and carrier fish in '''faeces, urine, sexual fluids and external mucus.'''
+IHNV is normally transmitted '''horizontally''' from fish to fish. Vertical transmission from fish to its offspring has been demonstrated; however, there is considerable discussion as to whether the virus is located within or external to the egg.
 ==Signalment==
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 ==Treatment==
 Treatment has been and is attempted with drugs such as '''amantidine, metisazone, ribavirin and benzimidazole''', but is '''ineffective.'''
 ==Control==
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 ==References==
 <references/>
 {{CABI source
 |datasheet = [http://www.cabi.org/ahpc/?compid=3&dsid=79281&loadmodule=datasheet&page=2144&site=160 infectious haematopoietic necrosis] and [http://www.cabi.org/ahpc/?compid=3&dsid=79278&loadmodule=datasheet&page=2144&site=160 infectious haematopoietic necrosis virus]
 |date =6 July 2011
 }}
-<br><br><br>
+<br><br>
 [[Category:CABI Expert Review]] [[Category:Fish Diseases]]

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-Also Known As – '''''IHN – Chinook Salmon Disease – Coleman Disease – Columbia River Sockeye Disease – Cultus Lake Virus Disease – Oregon Sockeye Disease – Sacramento River Chinook Disease – Sockeye Salmon Viral Disease'''''
+Also Known As: '''''IHN — Chinook Salmon Disease — Coleman Disease — Columbia River Sockeye Disease — Cultus Lake Virus Disease — Oregon Sockeye Disease — Sacramento River Chinook Disease — Sockeye Salmon Viral Disease'''''
-Caused By – ''Infectious Haematopoietic Necrosis Virus – IHNV – Sockeye Salmon Virus''
+Caused By: '''''Infectious Haematopoietic Necrosis Virus — IHNV — Sockeye Salmon Virus'''''
 ==Introduction==
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 In some outbreaks a '''sudden increase in mortality''' may be the first sign noted. Epizootics can begin as groups of moribund fish that whirl sporadically or exhibit periods of hyperactivity.
-Some recovered fish can become '''covert carriers'''.<ref> Kim, C. H., Dummer, D. M., Chiou, P. P., Leong, J. C (1999) '''Truncated particles produced in fish surviving infectious hematopoietic necrosis virus infection: mediators of persistence?'''. J Virology, 73(1):843-849</ref>
+Some recovered fish can become '''covert carriers'''.<ref> Kim, C. H., Dummer, D. M., Chiou, P. P., Leong, J. C (1999) '''Truncated particles produced in fish surviving infectious hematopoietic necrosis virus infection: mediators of persistence?'''. ''J Virology'', 73(1):843-849</ref>
 Mortality in yolk-sac fry and fish <2 months old can reach '''90%'''. Mortality is lower in older fish.
-Bloodwork of infected fish features '''leucopaenia, neutropaenia, increased numbers of erythrocytes which may be bilobed''', cellular debris, anaemia and low levels of bicarbonate, calcium, phosphorus, chloride and bilirubin.
+Bloodwork of infected fish features '''leucopaenia, [[neutropaenia]], increased numbers of erythrocytes which may be bilobed''', cellular debris, [[:Category:Anaemia|anaemia]] and low levels of bicarbonate, calcium, phosphorus, chloride and bilirubin.
 ==Diagnosis==
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 One of the '''most rapid tests, taking only 15 minutes, is staphylococcal agglutination''' which is performed upon '''cell cultures or infected fish tissues''' using formalin fixed ''Staphylococcus aureus'' cells sensitised with rabbit antiserum which caused agglutination of bacterial cells, visible under a standard light microscope. This test is specific but has poor sensitivity.
-Virus can be identified by '''Virus Neutralisation (VN),, Indirect Fluorescent Antibody Testing (IFAT), ELISA, PCR or DNA probe technology'''. It can be isolated from cell culture using kidney, spleen and sometimes mucus in non-lethal sampling methods. Ovarian fluid should be used if breeding stock are being tested. '''The approved test is Virus Neutralisation''' but this is expensive and time consuming, hence the development of more practical, rapid tests, however these are not officially approved.
+Virus can be identified by '''Virus Neutralisation (VN),, [[FAT|Indirect Fluorescent Antibody Testing (IFAT)]], [[ELISA testing|ELISA]], PCR or DNA probe technology'''. It can be isolated from cell culture using kidney, spleen and sometimes mucus in non-lethal sampling methods. Ovarian fluid should be used if breeding stock are being tested. '''The approved test is Virus Neutralisation''' but this is expensive and time consuming, hence the development of more practical, rapid tests, however these are not officially approved.
 On necropsy of infected fry, the liver, '''spleen and kidneys are pale due to anaemia and ascites is common'''.  The stomach will be full of '''milky fluid''' but no food. Petechial haemorrhages are common throughout many organs. Yellowish fluid or mucus in the intestines is seen in both young and adult fish. The haematopoietic tissues of the kidney and the spleen in young fish are most severely affected, demonstrating small, pale multifocal areas with macrophage infiltration and degenerating lymphoid cells.
-A '''pathognomic histological feature of IHN is degeneration and necrosis of granular cells in the lamina propria, stratum compactum and stratum granulosum of the gastrointestinal tract'''.
+A '''pathognomic '''histological feature of IHN is '''degeneration and necrosis of granular cells in the lamina propria, stratum compactum and stratum granulosum of the gastrointestinal tract'''.
-On cytopathology, cells appear '''balloon shaped and nuclei are displaced''' to one side.<ref>Engelking, H. M., Leong, J. C (1981) '''IHNV persistently infects chinook salmon embryo cells.''' Virology, 109(1):47-58</ref>
+On cytopathology, cells appear '''balloon shaped and nuclei are displaced''' to one side.<ref>Engelking, H. M., Leong, J. C (1981) '''IHNV persistently infects chinook salmon embryo cells.''' ''Virology'', 109(1):47-58</ref>
 Detection of antibodies to IHN is difficult and no test appears to give reliable results at present.
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 Animal Health & Production Compendium, '''Infectious Haematopoietic Necrosis datasheet''', accessed 06/07/2011 @ http://www.cabi.org/ahpc/
-[[Category:To Do - CABI review]] [[Category:Lymphoreticular Diseases Flashcards]]

← Older revision		Revision as of 21:59, 7 July 2011
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	Animal Health & Production Compendium, '''Infectious Haematopoietic Necrosis datasheet''', accessed 06/07/2011 @ http://www.cabi.org/ahpc/		Animal Health & Production Compendium, '''Infectious Haematopoietic Necrosis datasheet''', accessed 06/07/2011 @ http://www.cabi.org/ahpc/

−	[[Category:To Do - CABI review]] [[Category:Lymphoreticular Diseases]]	+	[[Category:To Do - CABI review]] [[Category:Lymphoreticular Diseases Flashcards]]