Insulinoma - Revision history

Michuang0720 at 20:46, 25 June 2016

2016-06-25T20:46:55Z

Bara at 19:50, 11 July 2012

2012-07-11T19:50:05Z

Bara: Text replace - "[[Pancreatitis - Dog and Cat|" to "[[Pancreatitis|"

2011-03-25T19:18:14Z

Text replace - "[[Pancreatitis - Dog and Cat|" to "[[Pancreatitis|"

Bara: /* References */

2010-12-21T11:08:34Z

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Bara: Text replace - "Category:Neurological Pathology - Dog" to "Category:Neurological Diseases - Dog"

2010-12-16T15:51:05Z

Text replace - "Category:Neurological Pathology - Dog" to "Category:Neurological Diseases - Dog"

Bara: Text replace - "Category:Endocrine Pathology - Dog" to "Category:Endocrine Diseases - Dog"

2010-12-16T15:41:11Z

Text replace - "Category:Endocrine Pathology - Dog" to "Category:Endocrine Diseases - Dog"

Bara: Text replace - "Category:Pancreatic Pathology - Dog" to "Category:Pancreatic Diseases - Dog"

2010-12-16T15:31:53Z

Text replace - "Category:Pancreatic Pathology - Dog" to "Category:Pancreatic Diseases - Dog"

Bara: /* References */

2010-12-15T18:03:13Z

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Bara: /* References */

2010-12-15T18:03:03Z

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Bara: /* References */

2010-12-14T18:35:41Z

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 {{Learning
 |literature search = [http://www.cabdirect.org/search.html?rowId=1&options1=AND&q1=Insulinoma&occuring1=title&rowId=2&options2=AND&q2=&occuring2=freetext&rowId=3&options3=AND&q3=&occuring3=freetext&x=44&y=8&publishedstart=yyyy&publishedend=yyyy&calendarInput=yyyy-mm-dd&la=any&it=any&show=all Insulinoma publications]
 }}

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-{{review}}
+{{OpenPagesTop}}
-==Description==
+==Introduction==
 [[Image:Islet cell tumour.jpg|right|thumb|100px|<small><center>Islet cell tumour (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]]
 '''Insulinomas''' are slow growing, well-encapsulated, functional tumours of the [[Pancreas - Anatomy & Physiology#Endocrine|beta cells]] of the pancreatic islets.  They secrete inappropriately high amounts of [[Pancreas - Anatomy & Physiology#Insulin|insulin]], irrespective of the serum glucose concentration.  They are often malignant, with a high metastatic rate to regional lymph nodes, [[Liver - Anatomy & Physiology|liver]] and omentum.  60% of insulinomas are carcinomas, which are more likely to be endocrinologically active whereas the others are adenomas.
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 This is related to the WHO stage of the tumour at diagnosis.  An animal with a stage I and II neoplastic process could expect a median survival time of 18 months but this falls to only 6 months for an animal with stage III disease.  Patients which undergo surgery to remove an insulinoma have a better prognosis than those treated medically but the condition will recur invariably after surgical removal.  Those animals which show a recurrence of clinical signs after surgery may then be treated medically, an approach that produces a significant increase in median survival time (from approximately 2 years to 4 years).
-==Literature Search==
+{{Learning
-[[File:CABI logo.jpg|left|90px]]
+|literature search = [http://www.cabdirect.org/search.html?rowId=1&options1=AND&q1=Insulinoma&occuring1=title&rowId=2&options2=AND&q2=&occuring2=freetext&rowId=3&options3=AND&q3=&occuring3=freetext&x=44&y=8&publishedstart=yyyy&publishedend=yyyy&calendarInput=yyyy-mm-dd&la=any&it=any&show=all Insulinoma publications]
+}}
 ==References==
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 [[Category:Pancreas_-_Hyperplastic_and_Neoplastic_Pathology]][[Category:Endocrine_System_-_Pathology]]

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 A '''partial pancreatectomy''' is suitable for patients with a solitary tumour and any suspected metastases may be removed or biopsied during the procedure.  An intra-operative ultrasound scan can be performed if the mass is not evident when the pancreas has been exposed.  Possible post-operative complications include:
 *'''Persistent hypoglycaemia''', probably due to the presence of unidentified metastases.
-*[[Pancreatitis - Dog and Cat|'''Pancreatitis]]''' or '''[[Diabetes Mellitus|Diabetes mellitus]]''' due to disruption to the pancreatic parenchyma during the procedure.
+*[[Pancreatitis|'''Pancreatitis]]''' or '''[[Diabetes Mellitus|Diabetes mellitus]]''' due to disruption to the pancreatic parenchyma during the procedure.
 *'''Epilepsy''' and '''diffuse polyneuropathy''' due to chronic hypoglycaemia.
 *'''Duodenal necrosis and perforation''' as the cranial pancreatico-duodenal artery may be disrupted when the right limb of the pancreas is dissected away from the duodenum.

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 [[Category:Pancreas_-_Hyperplastic_and_Neoplastic_Pathology]][[Category:Endocrine_System_-_Pathology]]
 [[Category:Neoplasia]][[Category:Pancreas_-_Hyperplastic_and_Neoplastic_Pathology]][[Category:Endocrine_System_-_Pathology]]
 [[Category:Endocrine Diseases - Dog]][[Category:Neurological Diseases - Dog]]
-[[Category:Cat]][[Category:Pancreatic Diseases - Dog]]
+[[Category:Endocrine Diseases - Dog]][[Category:Neurological Diseases - Dog]][[Category:Pancreatic Diseases - Dog]]
 [[Category:Expert_Review]]

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 [[Category:Pancreas_-_Hyperplastic_and_Neoplastic_Pathology]][[Category:Endocrine_System_-_Pathology]]
 [[Category:Neoplasia]][[Category:Pancreas_-_Hyperplastic_and_Neoplastic_Pathology]][[Category:Endocrine_System_-_Pathology]]
-[[Category:Endocrine Diseases - Dog]][[Category:Neurological Pathology - Dog]]
+[[Category:Endocrine Diseases - Dog]][[Category:Neurological Diseases - Dog]]
 [[Category:Cat]][[Category:Pancreatic Diseases - Dog]]
 [[Category:Expert_Review]]

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 [[Category:Neoplasia]][[Category:Pancreas_-_Hyperplastic_and_Neoplastic_Pathology]][[Category:Endocrine_System_-_Pathology]]
-[[Category:Cat]][[Category:Dog]]
+[[Category:Cat]][[Category:Pancreatic Pathology - Dog]]
 [[Category:Expert_Review]]