Isoflurane - Revision history

Shannanigans969: /* Pharmacokinetics */

2012-09-18T09:13:58Z

Pharmacokinetics

Shannanigans969: /* Pharmacokinetics */

2012-09-18T09:12:53Z

Pharmacokinetics

Bara at 15:20, 24 May 2011

2011-05-24T15:20:36Z

Bara at 16:46, 25 January 2011

2011-01-25T16:46:25Z

Karag7: /* Pharmacokinetics */

2009-09-01T16:30:37Z

Pharmacokinetics

A.allison at 15:03, 1 September 2009

2009-09-01T15:03:38Z

Hstenning at 15:00, 16 April 2009

2009-04-16T15:00:39Z

Hstenning: New page: {{unfinished}} '''Isoflurane''' is currently the most commonly used inhalation agent in veterinary practice. Similarly to halothane it's main use is as a maintenance agent a...

2009-04-16T14:43:12Z

New page: {{unfinished}} '''Isoflurane''' is currently the most commonly used inhalation agent in veterinary practice. Similarly to halothane it's main use is as a maintenance agent a...

New page

{{unfinished}}

'''Isoflurane''' is currently the most commonly used inhalation agent in veterinary practice. Similarly to [[Halothane|halothane]] it's main use is as a maintenance agent after induction with an [[Injectable agents| injectable agent]] but, again, can be used to induce patients. However, it does not have a pleasant odour and so many patients will breath hold. Isoflurane is licenced in most companion animals.

==Pharmacokinetics==
Isoflurane is a nonflammable and stable anaesthetic that, at room temperature is a liquid and so requires passage through a [[Vaporisers|vaporiser]]. Unlike [[Halothane|halothane]], it does not require a preservative, nor does it undergo ultraviolet degradation. The '''blood:gas coefficient''' is lower then that of halothane, meaning that is poorly blood soluble. This means that it cause rapid induction , recovery and depth of anaesthesia. The '''MAC''' for isoflurane is approximately ''1.3%'', making it ''less potent'' then halothane, but it is less tissue soluble. There is minimal metabolism to isoflurane, but any that occurs is in the liver.

==Adverse Effects==
===Central Nervous System===
*Isoflurane does not mar the cerebral circulation's response to carbon dioxide. This means that hyperventilation can be used to decrease ICP in these patients.

===Cardiovascular System===
*Myocardial contractility depression.
*Heart rate may increase, which helps control cardiac output in the face of depression of myocardial contractility.
*Decresase in arterial blood pressure due to decreased vascular resistance.

===Respiratory System===
*Ventilation depression.

===Other Systems===
*Decreases flow through the hepatic portal vein but increased flow through the hepatic artery, so hepatic damage is less likely.
*Like halothane, isoflurane can cause malignant hyperthermia in susceptible patients.

==Contraindications==
*Isoflurane should not be used in patients with a susceptilbility to malignant hyperthermia.
*It potentiates non-depolarising neuromuscular blocking agents.

@@ Line 3: / Line 3: @@
 ==Pharmacokinetics==
-Isoflurane is a nonflammable and stable anaesthetic that, at room temperature is a liquid and so requires passage through a [[Vaporisers|vaporiser]]. Unlike [[Halothane|halothane]], it does not require a preservative, nor does it undergo ultraviolet degradation. The '''blood:gas partition coefficient''' is lower than that of halothane, meaning that is poorly blood soluble. This means that it causes rapid induction , recovery and depth of anaesthesia. The '''MAC''' for isoflurane is approximately ''1.3%'' in dogs and ''1.6%'' in cats, making it ''less potent'' then halothane, but it is less tissue soluble. There is minimal metabolism to isoflurane, but any that occurs is in the liver.
+Isoflurane is a nonflammable and stable anaesthetic that, at room temperature, is a liquid and so requires passage through a [[Vaporisers|vaporiser]]. Unlike [[Halothane|halothane]], it does not require a preservative, nor does it undergo ultraviolet degradation. The '''blood:gas partition coefficient''' is lower than that of halothane, meaning that is poorly blood soluble. This means that it causes rapid induction , recovery and depth of anaesthesia. The '''MAC''' for isoflurane is approximately ''1.3%'' in dogs and ''1.6%'' in cats, making it ''less potent'' than halothane, but it is less tissue soluble. There is minimal metabolism to isoflurane, but any that occurs is in the liver.
 ==Adverse Effects==

@@ Line 3: / Line 3: @@
 ==Pharmacokinetics==
-Isoflurane is a nonflammable and stable anaesthetic that, at room temperature is a liquid and so requires passage through a [[Vaporisers|vaporiser]]. Unlike [[Halothane|halothane]], it does not require a preservative, nor does it undergo ultraviolet degradation. The '''blood:gas partition coefficient''' is lower then that of halothane, meaning that is poorly blood soluble. This means that it cause rapid induction , recovery and depth of anaesthesia. The '''MAC''' for isoflurane is approximately ''1.3%'' in dogs and ''1.6%'' in cats, making it ''less potent'' then halothane, but it is less tissue soluble. There is minimal metabolism to isoflurane, but any that occurs is in the liver.
+Isoflurane is a nonflammable and stable anaesthetic that, at room temperature is a liquid and so requires passage through a [[Vaporisers|vaporiser]]. Unlike [[Halothane|halothane]], it does not require a preservative, nor does it undergo ultraviolet degradation. The '''blood:gas partition coefficient''' is lower than that of halothane, meaning that is poorly blood soluble. This means that it causes rapid induction , recovery and depth of anaesthesia. The '''MAC''' for isoflurane is approximately ''1.3%'' in dogs and ''1.6%'' in cats, making it ''less potent'' then halothane, but it is less tissue soluble. There is minimal metabolism to isoflurane, but any that occurs is in the liver.
 ==Adverse Effects==

@@ Line 1: / Line 1: @@
 ==Introduction==
 '''Isoflurane''' is currently the most commonly used inhalation agent in veterinary practice. Similarly to [[Halothane|halothane]] it's main use is as a maintenance agent after induction with an [[Injectable Agents|injectable agent]] but, again, can be used to induce patients. However, it does not have a pleasant odour and so many patients will breath hold. Isoflurane is licenced in most companion animals.
@@ Line 27: / Line 26: @@
 [[Category:Inhalation Anaesthetic Agents]]

@@ Line 1: / Line 1: @@
 {{unfinished}}
-{{toplink
+==Introduction==
-|linkpage =Anaesthesia
+'''Isoflurane''' is currently the most commonly used inhalation agent in veterinary practice. Similarly to [[Halothane|halothane]] it's main use is as a maintenance agent after induction with an [[Injectable Agents|injectable agent]] but, again, can be used to induce patients. However, it does not have a pleasant odour and so many patients will breath hold. Isoflurane is licenced in most companion animals.
 ==Pharmacokinetics==
@@ Line 35: / Line 25: @@
 *Isoflurane should not be used in patients with a susceptilbility to malignant hyperthermia.
 *It potentiates non-depolarising neuromuscular blocking agents.

@@ Line 14: / Line 14: @@
 ==Pharmacokinetics==
-Isoflurane is a nonflammable and stable anaesthetic that, at room temperature is a liquid and so requires passage through a [[Vaporisers|vaporiser]]. Unlike [[Halothane|halothane]], it does not require a preservative, nor does it undergo ultraviolet degradation. The '''blood:gas partition coefficient''' is lower then that of halothane, meaning that is poorly blood soluble. This means that it cause rapid induction , recovery and depth of anaesthesia. The '''MAC''' for isoflurane is approximately ''1.3%'', making it ''less potent'' then halothane, but it is less tissue soluble. There is minimal metabolism to isoflurane, but any that occurs is in the liver.
+Isoflurane is a nonflammable and stable anaesthetic that, at room temperature is a liquid and so requires passage through a [[Vaporisers|vaporiser]]. Unlike [[Halothane|halothane]], it does not require a preservative, nor does it undergo ultraviolet degradation. The '''blood:gas partition coefficient''' is lower then that of halothane, meaning that is poorly blood soluble. This means that it cause rapid induction , recovery and depth of anaesthesia. The '''MAC''' for isoflurane is approximately ''1.3%'' in dogs and ''1.6%'' in cats, making it ''less potent'' then halothane, but it is less tissue soluble. There is minimal metabolism to isoflurane, but any that occurs is in the liver.
 ==Adverse Effects==