Key-Gaskell Syndrome - Revision history

Fiorecastro at 16:13, 5 January 2023

2023-01-05T16:13:57Z

NiallTaylor at 12:11, 15 March 2018

2018-03-15T12:11:00Z

TestStudent at 19:18, 1 September 2015

2015-09-01T19:18:50Z

Bara at 12:14, 9 August 2012

2012-08-09T12:14:14Z

Bara at 12:39, 3 May 2011

2011-05-03T12:39:57Z

Bara: /* References */

2011-03-09T14:20:17Z

References

Bara: /* References */

2010-12-21T17:38:33Z

References

Bara: Text replace - "Category:Dog - Neurological System" to "Category:Neurological Diseases - Dog"

2010-12-16T15:52:54Z

Text replace - "Category:Dog - Neurological System" to "Category:Neurological Diseases - Dog"

Bara: Text replace - "Category:Oesophageal Pathology - Dog" to "Category:Oesophageal Diseases - Dog"

2010-12-16T15:27:51Z

Text replace - "Category:Oesophageal Pathology - Dog" to "Category:Oesophageal Diseases - Dog"

Bara: Text replace - "Category:Intestinal Pathology - Dog" to "Category:Intestinal Diseases - Dog"

2010-12-16T15:24:02Z

Text replace - "Category:Intestinal Pathology - Dog" to "Category:Intestinal Diseases - Dog"

@@ Line 1: / Line 1: @@
-{{OpenPagesTop}}
 Also known as: '''''Autonomic Polyganglioneuropathy — Feline Dysautonomia
@@ Line 70: / Line 70: @@
 {{review}}
-{{OpenPages}}
+==Webinars==
 [[Category:Oesophagus_-_Pathology]]

@@ Line 7: / Line 7: @@
 The syndrome has occurred as outbreaks<ref>Cave TA, Knottenbelt C, Mellor DJ, Nunn F, Nart P, Reid SW '''Outbreak of dysautonomia (Key-Gaskell syndrome) in a closed colony of pet cats.''' ''Vet Rec. 2003 Sep 27;153(13):387-92.''</ref> in the past in the UK, continental Europe and occasionally in the USA. It was first described by Key and Gaskell as a 'puzzling syndrome' causing pupillary dilatation in cats at the start of a major outbreak in the UK in 1982<ref>Key TJ, Gaskell CJ. '''Puzzling syndrome in cats associated with pupillary dilatation.''' ''Vet Rec. 1982 Feb 13;110(7):160.''</ref>. It is currently described only sporadically but recent reports suggest that the incidence of the disease may be increasing again.
-The cause of the dysautonomia is not known but numerous factors have been implicated and it is generally thought to occur after exposure to a toxin, possibly in dry food or vaccines. As with grass sickness, it has also been suggested that toxins produced by ''[[Clostridium botulinum]]'' may be involved in the pathogenesis of the disease and a recent study showed that cats with the disease developed significantly higher titres of IgA antibody to botulinum toxins C and D than healthy controls<ref>Nunn F, Cave TA, Knottenbelt C, Poxton IR. '''Association between Key-Gaskell syndrome and infection by Clostridium botulinum type C/D.''' ''Vet Rec. 2004 Jul 24;155(4):111-5.''</ref>.  Whatever the cause, degenerative lesions develop in the autonomic ganglia, intermedio-lateral columns of spinal grey matter and in the axons of the sympathetic neurones.
+The cause of the dysautonomia is not known but numerous factors have been implicated and it is generally thought to occur after exposure to a toxin, possibly in dry food or vaccines [?reference]. As with grass sickness, it has also been suggested that toxins produced by ''[[Clostridium botulinum]]'' may be involved in the pathogenesis of the disease and a recent study showed that cats with the disease developed significantly higher titres of IgA antibody to botulinum toxins C and D than healthy controls<ref>Nunn F, Cave TA, Knottenbelt C, Poxton IR. '''Association between Key-Gaskell syndrome and infection by Clostridium botulinum type C/D.''' ''Vet Rec. 2004 Jul 24;155(4):111-5.''</ref>.  Whatever the cause, degenerative lesions develop in the autonomic ganglia, intermedio-lateral columns of spinal grey matter and in the axons of the sympathetic neurones.
 ==Signalment==

@@ Line 58: / Line 58: @@
 {{Learning
 |literature search = [http://www.cabdirect.org/search.html?q=%28title%3A%28%22Key+Gaskell%22%29+OR+title%3A%28dysatonomia%29+OR+title%3A%28%22Autonomic+Polyganglioneuropathy%22%29%29+AND+%28od%3A%28cats%29+OR+od%3A%28dogs%29%29 Key-Gaskell Syndrome in cats and dogs publications]
 }}

@@ Line 1: / Line 1: @@
 Also known as: '''''Autonomic Polyganglioneuropathy — Feline Dysautonomia
@@ Line 56: / Line 57: @@
 The prognosis is guarded or poor. Recovery rates in the cat are reported as 20-40% but it may take 2-12 months for the patient to recover fully. In the dog, recovery rates are lower. Even after making an apparent recovery, many animals are left with residual neurological deficits including intermittent regurgitation.
-==Literature Search==
+{{Learning
-[[File:CABI logo.jpg|left|90px]]
+|literature search = [http://www.cabdirect.org/search.html?q=%28title%3A%28%22Key+Gaskell%22%29+OR+title%3A%28dysatonomia%29+OR+title%3A%28%22Autonomic+Polyganglioneuropathy%22%29%29+AND+%28od%3A%28cats%29+OR+od%3A%28dogs%29%29 Key-Gaskell Syndrome in cats and dogs publications]
+}}
 ==References==
@@ Line 71: / Line 68: @@
 {{review}}
 [[Category:Oesophagus_-_Pathology]]
 [[Category:Intestinal Diseases - Cat]][[Category:Neurological Diseases - Cat]][[Category:Oesophageal Diseases - Cat]]

@@ Line 1: / Line 1: @@
 Also known as: '''''Autonomic Polyganglioneuropathy — Feline Dysautonomia
@@ Line 72: / Line 70: @@
+{{review}}
 [[Category:Oesophagus_-_Pathology]]
 [[Category:Intestinal Diseases - Cat]][[Category:Neurological Diseases - Cat]][[Category:Oesophageal Diseases - Cat]]
@@ Line 78: / Line 76: @@
 [[Category:Intestine_-_Functional_Obstruction]]
 [[Category:Peripheral Nervous System - Pathology]]
-[[Category:Expert Review]]
+[[Category:Expert Review - Small Animal]]

@@ Line 76: / Line 76: @@
 [[Category:Cat]]
 [[Category:Intestine_-_Functional_Obstruction]]
-[[Category:Intestinal Diseases - Dog]][[Category:Dog - Neurological System]][[Category:Oesophageal Diseases - Dog]][[Category:Expert Review]]
+[[Category:Intestinal Diseases - Dog]][[Category:Neurological Diseases - Dog]][[Category:Oesophageal Diseases - Dog]][[Category:Expert Review]]