Kidney Function and Age - Physiology - Revision history

Bara at 13:28, 15 August 2013

2013-08-15T13:28:12Z

W1k1vet at 11:26, 15 August 2013

2013-08-15T11:26:20Z

Bara at 14:20, 5 July 2012

2012-07-05T14:20:33Z

Bara at 15:00, 10 December 2010

2010-12-10T15:00:16Z

Bara at 16:31, 29 August 2010

2010-08-29T16:31:27Z

Suzannah.stacey at 19:40, 19 June 2010

2010-06-19T19:40:38Z

A.allison at 07:53, 8 October 2008

2008-10-08T07:53:58Z

Lwyatri: /* Kidney Function in the Old */

2008-09-06T16:49:34Z

Kidney Function in the Old

Lwyatri: /* Kidney Function in Newborns */

2008-09-06T16:49:11Z

Kidney Function in Newborns

Lwyatri at 16:46, 6 September 2008

2008-09-06T16:46:54Z

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 ==Kidney Function in the Old==
-As the animal begins to get old its glomerular filtration rate drops mainly due to two factors.  One being a reduction in the number of nephrons and the other being vascular changes.  Under normal conditions these kidneys function well but their reserve capacity is very limited.  This is an important consideration when administering drugs as many are excreted in the urine therefore if GFR (Glomerular Filtration rate) is reduced their excretion will be also meaning an older animal will have higher plasma levels of the drug for longer.
+As the animal begins to get old its glomerular filtration rate drops mainly due to two factors.  One being a reduction in the number of nephrons and the other being vascular changes.  Under normal conditions these kidneys function well but their reserve capacity is very limited.  This is an important consideration when administering drugs as many are excreted in the urine therefore if [[GFR]] (Glomerular Filtration rate) is reduced their excretion will be also meaning an older animal will have higher plasma levels of the drug for longer.
 ==Kidney Function in Newborns==

@@ Line 2: / Line 2: @@
 ==Kidney Function in the Old==
-As the animal begins to get old its glomerular filtration rate drops mainly due to two factors.  One being a reduction in the number of nephrons and the other being vascular changes.  Under normal conditions these kidneys function well but their reserve capacity is very limited.  This is an important consideration when administering drugs as many are excreted in the urine therefore if GFR is reduced their excretion will be also meaning an older animal will have higher plasma levels of the drug for longer.
+As the animal begins to get old its glomerular filtration rate drops mainly due to two factors.  One being a reduction in the number of nephrons and the other being vascular changes.  Under normal conditions these kidneys function well but their reserve capacity is very limited.  This is an important consideration when administering drugs as many are excreted in the urine therefore if GFR (Glomerular Filtration rate) is reduced their excretion will be also meaning an older animal will have higher plasma levels of the drug for longer.
 ==Kidney Function in Newborns==

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 ==Kidney Function in the Old==
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 During pregnancy the placenta takes care of the homeostatic function of the foetus.  The kidneys just produce the amniotic fluid.  This means that the foetus has a very low GFR compared to adults.  When born animals such as calves and piglets have relatively substantially lower GFR's compared to their adult counterparts.  This takes some time to be corrected.  In humans it is only at 2 to 3 years of age that children have relatively the same GFR and adults.  The increase is mainly thanks to an increase in blood perfusion and activation of nephrons, inactive during foetal life. This redued kidney capacity means that renal clearance of toxins and unwanted substances is not as efficent as it is in adults.  This puts newborns at greater risk from some poisons etc.  As with older animals this is an important consideration when administering drugs as many are excreted in the urine therefore if GFR is reduced their excretion will be also meaning an young animal will have higher plasma levels of the drug for longer.
 [[Category:Kidney - Anatomy & Physiology]]

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 ==Kidney Function in the Old==
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 During pregnancy the placenta takes care of the homeostatic function of the foetus.  The kidneys just produce the amniotic fluid.  This means that the foetus has a very low GFR compared to adults.  When born animals such as calves and piglets have relatively substantially lower GFR's compared to their adult counterparts.  This takes some time to be corrected.  In humans it is only at 2 to 3 years of age that children have relatively the same GFR and adults.  The increase is mainly thanks to an increase in blood perfusion and activation of nephrons, inactive during foetal life. This redued kidney capacity means that renal clearance of toxins and unwanted substances is not as efficent as it is in adults.  This puts newborns at greater risk from some poisons etc.  As with older animals this is an important consideration when administering drugs as many are excreted in the urine therefore if GFR is reduced their excretion will be also meaning an young animal will have higher plasma levels of the drug for longer.
-[[Category:Urinary System]]
+[[Category:Kidney - Anatomy & Physiology]]

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 |maplink = Urinary System (Content Map) - Anatomy & Physiology
 |tablelink = Urinary System (Table) - Anatomy & Physiology
 }}
 <br>
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 During pregnancy the placenta takes care of the homeostatic function of the foetus.  The kidneys just produce the amniotic fluid.  This means that the foetus has a very low GFR compared to adults.  When born animals such as calves and piglets have relatively substantially lower GFR's compared to their adult counterparts.  This takes some time to be corrected.  In humans it is only at 2 to 3 years of age that children have relatively the same GFR and adults.  The increase is mainly thanks to an increase in blood perfusion and activation of nephrons, inactive during foetal life. This redued kidney capacity means that renal clearance of toxins and unwanted substances is not as efficent as it is in adults.  This puts newborns at greater risk from some poisons etc.  As with older animals this is an important consideration when administering drugs as many are excreted in the urine therefore if GFR is reduced their excretion will be also meaning an young animal will have higher plasma levels of the drug for longer.

← Older revision		Revision as of 19:40, 19 June 2010
Line 14:		Line 14:
	==Kidney Function in Newborns==		==Kidney Function in Newborns==

−	During pregnancy the placenta takes care of the homeostatic function of the foetus. The kidneys just produce the amniotic fluid. This means that the foetus has a very low GFR compared to adults. When born animals such as calves and piglets have relatively substantially lower GFR's compared to their adult counterparts. This takes some time to be corrected. In humans it is only at 2 to 3 years of age that children have relatively the same GFR and adults. The increase is mainly thanks to an increase in blood perfusion and activation of nephrons, inactive during foetal life.	+	During pregnancy the placenta takes care of the homeostatic function of the foetus. The kidneys just produce the amniotic fluid. This means that the foetus has a very low GFR compared to adults. When born animals such as calves and piglets have relatively substantially lower GFR's compared to their adult counterparts. This takes some time to be corrected. In humans it is only at 2 to 3 years of age that children have relatively the same GFR and adults. The increase is mainly thanks to an increase in blood perfusion and activation of nephrons, inactive during foetal life. This redued kidney capacity means that renal clearance of toxins and unwanted substances is not as efficent as it is in adults. This puts newborns at greater risk from some poisons etc. As with older animals this is an important consideration when administering drugs as many are excreted in the urine therefore if GFR is reduced their excretion will be also meaning an young animal will have higher plasma levels of the drug for longer.
−
−	~~===Effect on the Animal===~~
−	This means ~~their~~ renal clearance of toxins and unwanted substances is not as efficent as ~~that of~~ adults. This puts ~~them~~ at greater risk from some poisons etc. ~~Also as~~ with older animals this is an important consideration when administering drugs as many are excreted in the urine therefore if GFR is reduced their excretion will be also meaning an young animal will have higher plasma levels of the drug for longer.

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 {{toplink
 |linkpage =Urinary System - Anatomy & Physiology
 |linktext =URINARY SYSTEM
 |maplink = Urinary System (Content Map) - Anatomy & Physiology
 |pagetype =Anatomy
 }}

← Older revision		Revision as of 16:49, 6 September 2008
Line 14:		Line 14:
	==Kidney Function in Newborns==		==Kidney Function in Newborns==

−	During pregnancy the placenta takes care of the homeostatic function of the foetus. The kidneys just produce the amniotic fluid. This means that the foetus has a very low GFR compared to adults. When born animals such as calves and piglets have relatively substantially lower GFR's compared to their adult counterparts. This takes some time to be corrected. In humans it is only at 2 to 3 years of age that children have relatively the same GFR and adults. The increase is mainly thanks to an increase in blood perfusion and activation of nephrons, inactive during foetal life. As with older animals this is an important consideration when ~~you consider that~~ many ~~drugs~~ are excreted in the urine therefore if GFR is reduced their excretion will be also meaning an young animal will have higher plasma levels of the drug for longer.	+	During pregnancy the placenta takes care of the homeostatic function of the foetus. The kidneys just produce the amniotic fluid. This means that the foetus has a very low GFR compared to adults. When born animals such as calves and piglets have relatively substantially lower GFR's compared to their adult counterparts. This takes some time to be corrected. In humans it is only at 2 to 3 years of age that children have relatively the same GFR and adults. The increase is mainly thanks to an increase in blood perfusion and activation of nephrons, inactive during foetal life.
		+
		+	===Effect on the Animal===
		+	This means their renal clearance of toxins and unwanted substances is not as efficent as that of adults. This puts them at greater risk from some poisons etc. Also as with older animals this is an important consideration when administering drugs as many are excreted in the urine therefore if GFR is reduced their excretion will be also meaning an young animal will have higher plasma levels of the drug for longer.

← Older revision		Revision as of 16:46, 6 September 2008
Line 14:		Line 14:
	==Kidney Function in Newborns==		==Kidney Function in Newborns==

−	During pregnancy the placenta takes care of the homeostatic function of the foetus. The kidneys just produce the amniotic fluid. This means that the foetus has a very low GFR compared to adults. When born animals such as calves and piglets have relatively substantially lower GFR's compared to their adult counterparts. This takes some time to be corrected. In humans it is only at 2 to 3 years of age that children have relatively the same GFR and adults. The increase is mainly thanks to an increase in blood perfusion and activation of nephrons, inactive during foetal life.	+	During pregnancy the placenta takes care of the homeostatic function of the foetus. The kidneys just produce the amniotic fluid. This means that the foetus has a very low GFR compared to adults. When born animals such as calves and piglets have relatively substantially lower GFR's compared to their adult counterparts. This takes some time to be corrected. In humans it is only at 2 to 3 years of age that children have relatively the same GFR and adults. The increase is mainly thanks to an increase in blood perfusion and activation of nephrons, inactive during foetal life. As with older animals this is an important consideration when you consider that many drugs are excreted in the urine therefore if GFR is reduced their excretion will be also meaning an young animal will have higher plasma levels of the drug for longer.