Laboratory mice strain information - Revision history

Bara at 21:47, 2 May 2012

2012-05-02T21:47:29Z

2012-05-02T21:46:52Z

2010-09-09T11:03:10Z

129 mice:

2010-08-27T15:25:08Z

Introduction

2010-08-27T15:22:59Z

2010-08-25T14:03:19Z

2010-08-25T13:58:07Z

2010-08-25T13:41:14Z

2010-08-25T13:15:32Z

2010-08-25T13:00:43Z

C57BL/6 (B6) mice:

← Older revision		Revision as of 21:47, 2 May 2012
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−	~~[[Category:Laboratory_animals]]~~
	=Common Inbred mice strains and their pathology=		=Common Inbred mice strains and their pathology=

← Older revision		Revision as of 21:46, 2 May 2012
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	* http://www.informatics.jax.org/greenbook/index.shtml		* http://www.informatics.jax.org/greenbook/index.shtml
−	[[Category:~~WikiPath]][[Category:WikiPath]][[Category:Rodents~~]]	+
		+	[[Category:Laboratory Animal Pathology]]

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 '''Spontaneous diseases:'''
-Hypercallosity, megaoesophagus, pulmonary proteinosis and epithelial hyalinosis, blepharitis, and conjunctivitis.
+Hypocallosity, megaoesophagus, pulmonary proteinosis and epithelial hyalinosis, blepharitis, and conjunctivitis.
 '''Common neoplasms:'''

← Older revision		Revision as of 15:25, 27 August 2010
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	[[Category:Laboratory_animals]]		[[Category:Laboratory_animals]]
−	~~==Introduction==~~
−	Most laboratory mice have contributions from both Mus musculus musculus and Mus musculus domesticus. There is evidence that smaller contributions also may have come from Mus musculus molossinus and Mus musculus castaneus. Therefore, they should not be referred to by species name, but rather as laboratory mice or by use of a specific strain or stock name. (In addition, some recently developed laboratory mouse strains are derived wholly from other Mus species or other subspecies, such as M. spretus). The laboratory mouse genome, including its retroelements, is a mosaic and an artificial creation, and there is no true "wildtype" laboratory mouse.
−	There are over 450 inbred strains that have arisen during the last century but the great majority of biomedical resaerch, including genomic research, is based on a relatively few mouse strains, including C57BL/6, BALB/c, C3H/He, 129, FVB, and outbred Swiss stocks.
−
	=Common Inbred mice strains and their pathology=		=Common Inbred mice strains and their pathology=

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 [[Category:Laboratory_animals]]
 Most laboratory mice have contributions from both Mus musculus musculus and Mus musculus domesticus. There is evidence that smaller contributions also may have come from Mus musculus molossinus and Mus musculus castaneus. Therefore, they should not be referred to by species name, but rather as laboratory mice or by use of a specific strain or stock name. (In addition, some recently developed laboratory mouse strains are derived wholly from other Mus species or other subspecies, such as M. spretus). The laboratory mouse genome, including its retroelements, is a mosaic and an artificial creation, and there is no true "wildtype" laboratory mouse.
 There are over 450 inbred strains that have arisen during the last century but the great majority of biomedical resaerch, including genomic research, is based on a relatively few mouse strains, including C57BL/6, BALB/c, C3H/He, 129, FVB, and outbred Swiss stocks.

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 ==C3H/He mice:==
-Agouti (brown) mice that are blind due to ''rd1'' mutation in the ''Pdeb'' gene.
+Agouti (brown) mice that are blind due to ''rd1'' mutation in the ''Pde6b'' gene.
 '''Spontaneous diseases:'''
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 ==FVB/N mice:==
+Inbred swiss mice, they are blind due to homozygosity of ''rd1'' allele (''Pde6b'' gene).
 '''Spontaneous diseases:'''
 '''Common neoplasms:'''
+Tumours of the lung, pituitary gland, Harderian gland, and liver. Also lymphomas and pheochromocytomas.
 == References==

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 ==BALB/c mice:==
-Are albinos. Mature males are rather pugilistic.
+Albinos. Mature males are rather pugilistic.
 '''Spontaneous diseases:'''
-Dystrophic epicardial mineralisation of the right ventricular free wall,  myocardial degeneration, auricular thrombosis, corneal opacities, hypocallosity (corpus callosus hypoplasia or even aplasia, age-related hearing loss.
+Dystrophic epicardial mineralisation of the right ventricular free wall,  myocardial degeneration, auricular thrombosis, corneal opacities, hypocallosity (corpus callosus hypoplasia or even aplasia), age-related hearing loss.
-BALB mice are markedly ressistant to amyloidosis
+BALB mice are markedly ressistant to amyloidosis.
 '''Common neoplasms:'''
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 ==C3H/He mice:==
+Agouti (brown) mice that are blind due to ''rd1'' mutation in the ''Pdeb'' gene.
 '''Spontaneous diseases:'''
 '''Common neoplasms:'''
 ==129 mice:==
+Represent the most frequent source of embryonic stem cells (ES cells). The 129 mouse is not a single strain, and in fact the "129" is represented by 16 recognised strains and substrains.
 '''Spontaneous diseases:'''

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 ==C57BL/6 (B6) mice:==
-Background srain, longelivity. Their melanism is manifested by their coat colour. melanin pigment in heart valves, splenic capsule and meninges.
+Gold standard background strain for GEM's, genome of this strain has been fully sequenced. B6 mice were initially bred for their longevity. Their melanism is manifested by their coat colour. melanin pigment in heart valves, splenic capsule and meninges.
 '''Spontaneous diseases:'''
-Hydrocephalus, hippocampal neurodegeneration, microphtalmia, anophtalmia, age realted cochlear degeneration (hearing loss), malocclusion and pulmonary proteinosis.
+Hydrocephalus, hippocampal neurodegeneration, microphtalmia, anophtalmia, age-related cochlear degeneration (hearing loss), malocclusion and pulmonary proteinosis.
 '''Common neoplasms:'''
+Lymphoma (especially B-cell), haemangiosarcoma, and pituitary adenoma (especially prolactin-secreting cells)
 ==BALB/c mice:==