Leukocytes - Revision history

Fiorecastro at 17:06, 11 April 2022

2022-04-11T17:06:40Z

JoeWright at 09:03, 16 March 2022

2022-03-16T09:03:28Z

Fiorecastro at 16:37, 15 March 2022

2022-03-15T16:37:42Z

Fiorecastro at 13:51, 15 March 2022

2022-03-15T13:51:50Z

Fiorecastro at 17:55, 10 March 2022

2022-03-10T17:55:30Z

Fiorecastro at 17:48, 10 March 2022

2022-03-10T17:48:18Z

Bara at 19:13, 17 December 2012

2012-12-17T19:13:41Z

A.allison: Reverted edits by A.allison (talk) to last revision by Suzannah.stacey

2011-01-24T22:09:54Z

Reverted edits by A.allison (talk) to last revision by Suzannah.stacey

A.allison: Undo revision 105928 by A.allison (talk)

2011-01-24T22:09:47Z

Undo revision 105928 by A.allison (talk)

A.allison at 22:09, 24 January 2011

2011-01-24T22:09:13Z

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 |<p>'''[[Mast Cells|Mast cell]]'''</p><sup>©Nottingham Uni 2008</sup>
 |}
 [[Category:Blood Cells]]

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 == Authors and References ==
 Inherited disorders of Leukocyts: [[NationWide Laboratories]]
 [[Category:Blood Cells]]

@@ Line 30: / Line 30: @@
 === Pelger-Huet anomaly ===
-[[File:NWLLabfacts 34.jpg|thumb|Pelger-Huet Anomaly NationWide Laboratories]]
+[[File:NWLLabfacts 34.jpg|thumb|'''Pelger-Huet Anomaly''' ©NationWide Laboratories 2017]]
 This is an inherited disorder of leucocytes in dogs, cats, rabbits, horses and humans, characterised by hyposegmentation of granulocytes. Mature neutrophils have the appearance of metamyelocytes and the overall picture mimics a severe degenerative left shift, although nuclear chromatin is mature and toxic changes are not evident. No clinical signs are evident in heterozygous individuals, homozygous individuals die in utero or perinatally.
 === Chediak-Higashi syndrome ===
-[[File:NWLLabfacts 35.jpg|thumb|Chediak-Higashi Syndrome NationWide Laboratories]]
+[[File:NWLLabfacts 35.jpg|thumb|'''Chediak-Higashi''' Syndrome ©NationWide Laboratories 2017]]
 This is reported in Persian cats and cattle. Affected individuals exhibit partial albinism, increased susceptibility to infections and bleeding diatheses. Large membrane bound vesicles are present in many cells including leucocytes and melanocytes. These result from the abnormal fusion of lysosomes during cell development. Neutrophils and eosinophils contain giant granules which look like inclusions; they show decreased mobility, defective phagocytic and bactericidal responses. Bleeding tendencies are due to the absence in platelets of normal dense granules.

@@ Line 43: / Line 43: @@
 == Authors and References ==
-Inherited disorders of Leukocyts: [[NationWide Laboratories#In Partnership with NationWide Laboratories]]
+Inherited disorders of Leukocyts: [[NationWide Laboratories]]
 [[Category:Blood Cells]]

@@ Line 43: / Line 43: @@
 == Authors and References ==
-[[NationWide Laboratories#In Partnership with NationWide Laboratories]]
+Inherited disorders of Leukocyts: [[NationWide Laboratories#In Partnership with NationWide Laboratories]]
 [[Category:Blood Cells]]

← Older revision		Revision as of 17:48, 10 March 2022
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	\|}		\|}

		+	== Inherited disorders of Leukocyts ==

		+	=== B2 Integrin adhesion molecule deficiencies ===
		+	This leucocyte adhesion deficiency-1 (LAD-1) results in decreased adhesion, impaired chemotaxis and minimal bactericidal function. Monocyte activity is also impaired. Affected animals suffe from recurrent bacterial and fungal infections without purulent inflammation. There is frequently a peripheral neutrophila, +/- a left shift and monocytosis. This condition has been reported in Irish Setters and Holstein cattle.
		+
		+	=== Pelger-Huet anomaly ===
		+	[[File:NWLLabfacts 34.jpg\|thumb\|Pelger-Huet Anomaly NationWide Laboratories]]
		+	This is an inherited disorder of leucocytes in dogs, cats, rabbits, horses and humans, characterised by hyposegmentation of granulocytes. Mature neutrophils have the appearance of metamyelocytes and the overall picture mimics a severe degenerative left shift, although nuclear chromatin is mature and toxic changes are not evident. No clinical signs are evident in heterozygous individuals, homozygous individuals die in utero or perinatally.
		+
		+	=== Chediak-Higashi syndrome ===
		+	[[File:NWLLabfacts 35.jpg\|thumb\|Chediak-Higashi Syndrome NationWide Laboratories]]
		+	This is reported in Persian cats and cattle. Affected individuals exhibit partial albinism, increased susceptibility to infections and bleeding diatheses. Large membrane bound vesicles are present in many cells including leucocytes and melanocytes. These result from the abnormal fusion of lysosomes during cell development. Neutrophils and eosinophils contain giant granules which look like inclusions; they show decreased mobility, defective phagocytic and bactericidal responses. Bleeding tendencies are due to the absence in platelets of normal dense granules.
		+
		+	=== Cylcic haemotapoiesis ===
		+	Previously known as cyclic neutropaenia, this condition is transmitted as an autosomal recessive trait in grey collie dogs. There is an 11-14 day cycle of neutropaenia with cyclic changes in platelet and reticulocyte counts although the PCV is not usually affected. Neutrophils may be completely absent during neutropaenic episodes which persist for 2-4 days. There is high mortality in affected puppies, most do not survive beyond 6 months of age.
		+
		+	'''Storage diseases.''' Lysosomes are membrane bound vesicles, containing enzymes which are capable of degrading the majority of biologically important macromolecules. An inherited deficiency in anyone of these enzymes results in the accumulation of substrate within lysosomes; in type i/v mucopolysaccharidosis, for example, this may be evident as blue-magenta coloured granules within the neutrophils’ cytoplasm.
		+
		+	== Authors and References ==
		+	[[NationWide Laboratories#In Partnership with NationWide Laboratories]]
	[[Category:Blood Cells]]		[[Category:Blood Cells]]

← Older revision		Revision as of 19:13, 17 December 2012
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	\|<p>'''[[Mast Cells\|Mast cell]]'''</p><sup>©Nottingham Uni 2008</sup>		\|<p>'''[[Mast Cells\|Mast cell]]'''</p><sup>©Nottingham Uni 2008</sup>
	\|}		\|}
		+
		+
		+	[[Category:Blood Cells]]

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-More commonly referred to as white blood cells. They are formed by the process known as [[Leukopoiesis|leukopoiesis]]. Leukocytes are sub divided into granulocytes and agranulocytes; granulocytes have a granular cytoplasm and polymorphic nuclei such as is seen in [[Neutrophils|neutrophils]], [[Eosinophils|eosinophils]], and [[Basophils|basophils]]. Granulocytes function as part of the non specific natural immune response to infection and as part of the inflammatory response to tissue injury.
+More commonly referred to as white blood cells. They are formed by the process known as [[leukopoiesis|leukopoiesis]]. Leukocytes are sub divided into granulocytes and agranulocytes; granulocytes have a granular cytoplasm and polymorphic nuclei such as is seen in [[Neutrophils|neutrophils]], [[Eosinophils|eosinophils]], and [[Basophils|basophils]]. Granulocytes function as part of the non specific natural immune response to infection and as part of the inflammatory response to tissue injury.
 The agranulocytes include [[Lymphocytes - Introduction|lymphocytes]] and [[Monocytes|monocytes]]. Lymphocytes differ from granulocytes and monocytes as they form part of the acquired immune response, dividing into B or T cells to fight attacks by foreign cells, bacteria and viruses. Monocytes leave the blood stream to enter tissues where they become [[Macrophages|macrophages]], which engulf bacteria and tissue debris by phagocytosis.
 ==The cells==
-== The cells ==
+{|border="2" cellspacing="4" cellpadding="3" rules="all" style="margin:1em 1em 1em 0; border:solid 1px #AAAAAA; border-collapse:collapse;empty-cells:show;{{{style|}}}"
 |-align="center"
-{{{style|}}}"&gt;
+|{{click|height =150px|width =150px|top=20px||link =Neutrophils|image =LH Neutrophil Histology Smaller.jpg}}
 |{{click|width =150px|height =150px|top=1px|link =Lymphocytes|image =LH Lymphocyte Histology.jpg}}
-{| border="2" cellspacing="4" cellpadding="3" rules="all" style="margin:1em 1em 1em 0; border:solid 1px #AAAAAA; border-collapse:collapse;empty-cells:show;<span class=" fck_mw_template"=""
+|{{click|width =150px|height =150px|top=10px|link =Eosinophils|image =LH Eosinophil Histology.jpg}}
-|- align="center"
+|{{click|height =150px|width =150px|top=5px|link =Monocytes|image =LH Monocyte Histology.jpg}}
-| {{click|height =150px|width =150px|top=20px||link =Neutrophils|image =LH Neutrophil Histology Smaller.jpg}}
+|-align="center"
-| {{click|width =150px|height =150px|top=1px|link =Lymphocytes|image =LH Lymphocyte Histology.jpg}}
+|<p>'''[[Neutrophils|Neutrophil]]'''</p><sup>©RVC 2008</sup>
-| {{click|width =150px|height =150px|top=10px|link =Eosinophils|image =LH Eosinophil Histology.jpg}}
+|<p>'''[[Lymphocytes - Introduction|Lymphocyte]]'''</p><sup>©RVC 2008</sup>
-| {{click|height =150px|width =150px|top=5px|link =Monocytes|image =LH Monocyte Histology.jpg}}
+|<p>'''[[Eosinophils|Eosinophil]] (Feline)'''</p><sup>©RVC 2008</sup>
-|- align="center"
+|<p>'''[[Monocyte]] (Canine)'''</p><sup>©RVC 2008</sup>
 |-
-| {{click|width =150px|height =150px|link =Basophils|image =LH Basophil Histology.jpg}}
+|{{click|width =150px|height =150px|link =Basophils|image =LH Basophil Histology.jpg}}
-| {{click|width =110px|height =150px|link =Macrophages|image =LH Macrophage Histology.jpg}}
+|{{click|width =110px|height =150px|link =Macrophages|image =LH Macrophage Histology.jpg}}
-| {{click|width =150px|height =150px|link =Mast Cells|image =LH Mast cell Histology.jpg}}
+|{{click|width =150px|height =150px|link =Mast Cells|image =LH Mast cell Histology.jpg}}
-|- align="center"
+|-align="center"
+|<p>'''[[Basophils|Basophil]] (Equine)'''</p><sup>©RVC 2008</sup>
-'''[[Basophils|Basophil]] (Equine)'''
+|<p>'''[[Macrophages|Macrophage]]'''</p><sup>©Nottingham Uni 2008</sup>
-<sup>©RVC 2008</sup>
+|<p>'''[[Mast Cells|Mast cell]]'''</p><sup>©Nottingham Uni 2008</sup>
 |}