Malignant Catarrhal Fever Virus - Revision history

Bara at 17:00, 30 July 2012

2012-07-30T17:00:50Z

Bara at 15:27, 19 June 2011

2011-06-19T15:27:55Z

Bara at 22:18, 5 May 2011

2011-05-05T22:18:39Z

Bara: /* Clinical Signs */

2011-03-28T09:42:52Z

Clinical Signs

Bara at 09:42, 28 March 2011

2011-03-28T09:42:26Z

Kthompson at 16:53, 24 March 2011

2011-03-24T16:53:25Z

Kthompson at 16:51, 24 March 2011

2011-03-24T16:51:40Z

Bara: /* Control */

2011-01-17T16:45:30Z

Control

Bara at 11:52, 17 January 2011

2011-01-17T11:52:26Z

Bara: Text replace - "[[Lymphocytes|" to "[[Lymphocytes - Introduction|"

2010-08-18T12:42:00Z

Text replace - "[[Lymphocytes|" to "[[Lymphocytes - Introduction|"

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 Also know as: '''''MCFV — MCF'''''
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 {{review}}
 [[Category:Herpesviridae]] [[Category:Cattle_Viruses]] [[Category:Oral_Diseases_-_Cattle]] [[Category:Respiratory_Diseases_-_Cattle]] [[Category:Oral_Cavity_-_Erosive_&_Ulcerative_Pathology]] [[Category:Neurological Diseases - Cattle]][[Category:Dermatological Diseases - Cattle]][[Category:Expert Review - Farm Animal]]

← Older revision		Revision as of 15:27, 19 June 2011
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−	Also know as: '''''MCFV - MCF'''''	+	Also know as: '''''MCFV — MCF'''''

	== Introduction ==		== Introduction ==

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 Also know as: '''''MCFV - MCF'''''
 == Introduction  ==
 [[Image:MCF1.gif|thumb|right|200px|<small><center>Severe oculo-nasal Discharge of MCF (Courtesy of Alun Williams (RVC))</center></small>]]
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+{{review}}
 [[Category:Herpesviridae]] [[Category:Cattle_Viruses]] [[Category:Oral_Diseases_-_Cattle]] [[Category:Respiratory_Diseases_-_Cattle]] [[Category:Oral_Cavity_-_Erosive_&_Ulcerative_Pathology]] [[Category:Neurological Diseases - Cattle]][[Category:Dermatological Diseases - Cattle]][[Category:Expert Review - Farm Animal]]

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 == Clinical Signs  ==
-Clinical signs in '''cattle''' are severe and include necrotising lesions in  the upper respiratory tract and eye: conjunctivitis and corneal oedema / opacity (keratitis or "blue eye" - characteristic feature). Pyrexia and diarrhoea with severe oculo-nasal discharge and inappetance also occurs. The animal will appear dull with ulcers on its muzzle, which exude a brown exudate. These may spread to the rest of the face and occasionally the whole body. There may also be ulcers on the tongue, dental pad, and cheeks that regularly become secondarily infected. [[Lymhocytes - Introduction|Lymphocyte]] proliferation to viral antigen in the blood vessels of lymph nodes, spleen lungs, liver and kidneys progresses until death occurs. The lymph nodes eventually become completely replaced by [[Lymph Nodes - Anatomy & Physiology#Follicles|lymphoblasts]], which is a similar pathogenesis to [[lymphosarcoma]]. There may also be vasculitis with medial necrosis of blood vessels throughout body with infiltration of walls of vessels by lymphocytes.
+Clinical signs in '''cattle''' are severe and include necrotising lesions in  the upper respiratory tract and eye: conjunctivitis and corneal oedema / opacity (keratitis or "blue eye" - characteristic feature). Pyrexia and diarrhoea with severe oculo-nasal discharge and inappetance also occurs. The animal will appear dull with ulcers on its muzzle, which exude a brown exudate. These may spread to the rest of the face and occasionally the whole body. There may also be ulcers on the tongue, dental pad, and cheeks that regularly become secondarily infected. [[Lymphocytes - Introduction|Lymphocyte]] proliferation to viral antigen in the blood vessels of lymph nodes, spleen lungs, liver and kidneys progresses until death occurs. The lymph nodes eventually become completely replaced by [[Lymph Nodes - Anatomy & Physiology#Follicles|lymphoblasts]], which is a similar pathogenesis to [[lymphosarcoma]]. There may also be vasculitis with medial necrosis of blood vessels throughout body with infiltration of walls of vessels by lymphocytes.
 == Diagnosis  ==

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 == Introduction  ==
+[[Image:MCF1.gif|thumb|right|200px|<small><center>Severe oculo-nasal Discharge of MCF (Courtesy of Alun Williams (RVC))</center></small>]]
-This virus is of the herpesviridae family and the reservoir species are&nbsp;wildebeest and&nbsp;sheep, each transferring different forms of the virus. Each virus is i'''nnocuous''' to the reservoir host, but can sometimes cause a peculiar and fatal over&nbsp;T-cell division in dead end hosts.&nbsp;Dead end hosts include cows, kudu and&nbsp;some deer.
+[[Image:MCF2.gif|thumb|right|200px|<small><center>Fissures on tongue (no vesicles) in MCF (Courtesy of Alun Williams (RVC))</center></small>]]
 MCFV is endemic as a latent infection in Blue Wildebeest and the virus is excreted in large amounts in the periparturient period.
-The disease is not all that common in UK, but is present. Outbreaks are usually sporadic and are often seen in animals mixing with sheep (carriers). In parts of Africa, you will see longer duration&nbsp;outbreaks, caused by different serotypes carried by Wildebeest. In deer, very serious outbreaks occur and this is probably due to infection with the sheep virus.
+The disease is not all that common in UK, but is present. Outbreaks are usually sporadic and are often seen in animals mixing with sheep (carriers). In parts of Africa, you will see longer duration outbreaks, caused by different serotypes carried by Wildebeest. In deer, very serious outbreaks occur and this is probably due to infection with the sheep virus.
 == Signalment  ==
-Latent infection in Blue Wildebeest and Sheep of all ages, breeds and sex. In dead end hosts it can affect any sex or age, but is often seen most in youngish animals around&nbsp;6 months to 1 year of age.
+Latent infection in Blue Wildebeest and sheep of all ages, breeds and sex. In dead end hosts, it can affect any sex or age, but is often seen most in youngish animals around 6 months to 1 year of age.
 == Clinical Signs  ==
-[[Image:MCF1.gif|thumb|right|125px|<small><center>Sever Oculo-nasal Discharge of MCF (Courtesy of Alun Williams (RVC))</center></small>]]
+Clinical signs in '''cattle''' are severe and include necrotising lesions in  the upper respiratory tract and eye: conjunctivitis and corneal oedema / opacity (keratitis or "blue eye" - characteristic feature). Pyrexia and diarrhoea with severe oculo-nasal discharge and inappetance also occurs. The animal will appear dull with ulcers on its muzzle, which exude a brown exudate. These may spread to the rest of the face and occasionally the whole body. There may also be ulcers on the tongue, dental pad, and cheeks that regularly become secondarily infected. [[Lymhocytes - Introduction|Lymphocyte]] proliferation to viral antigen in the blood vessels of lymph nodes, spleen lungs, liver and kidneys progresses until death occurs. The lymph nodes eventually become completely replaced by [[Lymph Nodes - Anatomy & Physiology#Follicles|lymphoblasts]], which is a similar pathogenesis to [[lymphosarcoma]]. There may also be vasculitis with medial necrosis of blood vessels throughout body with infiltration of walls of vessels by lymphocytes.
-Clinical signs in&nbsp;cattle are severe and include n[[Image:MCF2.gif|thumb|right|125px|<small><center>Fissures on tongue (no vesicles) in MCF (Courtesy of Alun Williams (RVC))</center></small>]]ecrotising lesions in&nbsp; the upper respiratory tract and eye: conjunctivitis and corneal oedema / opacity (keratitis or "blue eye" - characteristic feature).&nbsp;Pyrexia and diarrhoea with severe oculo-nasal discharge and inappetance also occurs. The animal will appear dull with ulcers on its muzzle, which exude a brown exudate. These&nbsp;may spread to the rest of the face and occasionally the whole body. There may also be ulcers also on the tongue, dental pad, and cheeks that regularly become secondarily infected.Lymphocyte proliferation to viral anitgen in the blood vessels of lymph nodes, spleen lungs, liver and kidneys progresses until death occurs. The lymph nodes eventually become completely replaced by [[Lymph Nodes - Anatomy & Physiology#Follicles|lymphoblasts]],&nbsp;which is a similar pathogenesis to lymphosarcoma. There may also be vasculitis with medial necrosis of blood vessels throughout body with infiltration of walls of vessels by [[Lymphocytes - Introduction|lymphocytes]].
+== Diagnosis  ==
-<br>
+History (where and what has the animal been stocked with), signalment (deer, cattle etc) and clinical signs are quite characteristic and will lead to a preliminary diagnosis of the disease. Definitive diagnosis can be achieved by performing PCR for detection of the herpesvirus DNA.
-== Diagnosis  ==
+== Treatment and Control  ==
-History (where and what has the animal been stocked with), Signalment (Deer, Cattle etc) and Clinical Signs are quite characteristic and will lead to a preliminary diagnosis of the disease. Definitive diagnosis can be achieved by performing PCR for detection of the herpesvirus DNA.
+The main control measures is to not stock Wildebeest in zoos, where possible as they are latent innocuous carries of the disease. Sheep and deer should also not be housed together.
-<br>
+== References  ==
-== Treatment and Control  ==
+Bridger, J and Russell, P (2007) '''Virology Study Guide''', ''Royal Veterinary College''
-The main control measures is to not stock Wildebeest in zoos, where possible&nbsp;as they are latent innocuous carries of the disease. Sheep and deer should also not be housed together.
+Divers, T.J. and Peek, S.F. (2008) '''Rebhun's diseases of dairy cattle''' ''Elsevier Health Scieneces''
-<br>
+Merck &  Co (2008) '''The Merck Veterinary Manual''' (Eighth Edition) ''Merial''
-== References  ==
+Radostits, O.M, Arundel, J.H, and Gay, C.C. (2000) '''Veterinary Medicine: a textbook of the diseases of cattle, sheep, pigs, goats and horses''''' Elsevier Health Sciences''
-[[Category:Herpesviridae]] [[Category:Cattle_Viruses]] [[Category:Oral_Diseases_-_Cattle]] [[Category:Respiratory_Diseases_-_Cattle]] [[Category:Oral_Cavity_-_Erosive_&_Ulcerative_Pathology]] [[Category:To_Do_-_Review]]
+[[Category:Herpesviridae]] [[Category:Cattle_Viruses]] [[Category:Oral_Diseases_-_Cattle]] [[Category:Respiratory_Diseases_-_Cattle]] [[Category:Oral_Cavity_-_Erosive_&_Ulcerative_Pathology]] [[Category:Neurological Diseases - Cattle]][[Category:Dermatological Diseases - Cattle]][[Category:Expert Review - Farm Animal]]

@@ Line 35: / Line 35: @@
-[[Category:Herpesviridae]][[Category:Cattle Viruses]][[Category:Alimentary Diseases - Cattle]]
+[[Category:Herpesviridae]][[Category:Cattle Viruses]][[Category:Oral Diseases - Cattle]][[Category:Respiratory Diseases - Cattle]]
 [[Category:Oral Cavity - Erosive & Ulcerative Pathology]]
 [[Category:To Do - Clinical/Viruses]]

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 *Wildebeest should not be stocked in zoos where possible
 *Sheep and deer should be housed separately
 [[Category:Herpesviridae]][[Category:Cattle]]
 [[Category:Oral Cavity - Erosive & Ulcerative Pathology]]
 [[Category:To Do - Clinical/Viruses]]

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 *Lymph nodes completely replaced by [[Lymph Nodes - Anatomy & Physiology#Follicles|lymphoblasts]] - similar to lymphosarcoma
-*Also vasculitis with medial necrosis of blood vessels throughout body with infiltration of walls of vessels by [[Lymphocytes|lymphocytes]].
+*Also vasculitis with medial necrosis of blood vessels throughout body with infiltration of walls of vessels by [[Lymphocytes - Introduction|lymphocytes]].
 *Ulcers are due to hypoxia of epithelium resulting from vascular lesions
 *Sporadically induce a fatal '''over-active T cell division''', where virus encodes anti-apoptotic protein in dead-end host