Mast Cells - Revision history

Rjfrancisrvc: /* Granules */

2012-05-22T14:32:29Z

Granules

Rjfrancisrvc: /* Development */

2012-05-22T14:29:31Z

Development

Ctrace: /* References */

2011-05-24T11:01:34Z

References

Kate English at 12:53, 16 February 2011

2011-02-16T12:53:03Z

Suzannah.stacey: /* In pathology */

2010-09-22T17:12:38Z

In pathology

Suzannah.stacey: /* In pathology */

2010-09-22T17:12:10Z

In pathology

Suzannah.stacey: /* In pathology */

2010-09-22T17:11:36Z

In pathology

Suzannah.stacey: /* Granules */

2010-09-22T17:03:53Z

Granules

Suzannah.stacey: /* Development */

2010-09-22T17:00:47Z

Development

Suzannah.stacey at 16:58, 22 September 2010

2010-09-22T16:58:23Z

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 * Preformed mediators such as serotonin, histamine, proteoglycans, heparin and serine proteases (tryptase and/or chymase)
 * Lipid mediators such as leukotrienes and prostaglandin D2
-* Cytokines: Il-3, Il-4, Il-5, Il-6, Il-8, Il-13, Il-16 TNF-α</p>
+* Cytokines: IL-3, IL-4, IL-5, IL-6, IL-8, IL-13, IL-16 and TNF-α</p>
-*Chemotactic factors for both [[Neutrophils|neutrophils]] and [[Eosinophils|eosinophils]]
+* Chemotactic factors for both [[Neutrophils|neutrophils]] and [[Eosinophils|eosinophils]]
 <p>Histamine increases vascular permeability, mucous production and smooth muscle tone in the respiratory tract and is responsible for the itch sensation in the skin. Heparin is an anticoagulant and binds with antithrombin III and platelet factor IV to block coagulation factors. Leukotrienes like histamine are responsible for contraction of respiratory smooth muscle. Chymase plays a role in the production of angiotensin II.</p>
 <p>Mast Cell granules are thought to produce a ground substance to facilitate collagen formation which occurs during the repair of an injury.</p>

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 <p>Mast cells are derived from the same stem cell line as [[Basophils|basophils]] and while they are similar to basophils they are not identical. Mast cells are found in connective tissue and are larger than other [[Leukocytes|leukocytes]] at 15-20µm. They have cytoplasm containing a high number of large, intensely staining basophilic granules which mask the nucleus.</p>
 ==Development==
-<p>Mast cells colony forming units (CFU) develop in the [[Bone Marrow - Anatomy & Physiology|bone marrow]] from the myeloid set cell ([[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]]) under the stimulation of IL-3 and Stem Cell Factor. Then under the stimulation of Il-6 and SCF the immature mast cells are formed. These then enter circulation where they remain undifferentiated. On migration into tissue they then differentiate, under stimulation by Il-4, and produce their granules. Once in the tissue mast cells may last for weeks to months.</p>
+<p>Mast cells colony forming units (CFU) develop in the [[Bone Marrow - Anatomy & Physiology|bone marrow]] from the myeloid stem cell ([[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]]) under the stimulation of IL-3 and Stem Cell Factor (SCF). Then under the continual stimulation with SCF, and with the additional stimulation with IL-6, the immature mast cells are formed. These then enter circulation where they remain undifferentiated. On migration into tissue they then differentiate, under stimulation by IL-4, and produce their granules. Once in the tissue mast cells may last for weeks to years.</p>
 ==Granules==

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 *Classically a cell involved in [[Acute Inflammation|acute inflammation]]
 *[[Neoplasia_-_Pathology#Mast_Cell_Proliferation_Disorders|Mast cell tumours]] of the intestine, liver and skin.
 ==References==

← Older revision		Revision as of 12:53, 16 February 2011
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	<br>		<br>

−	[[Category:Blood_Cells]]	+	[[Category:Blood_Cells]] [[Category:Kate English reviewing]]

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 ==In pathology==
 *Classically a cell involved in [[Acute Inflammation|acute inflammation]]
-*[[Neoplasia_-_Pathology#Mast_Cell_Proliferation_Disorders|Mast cell tumours]] of the intestine, [[Mast Cell Tumour|liver]] and skin.
+*[[Neoplasia_-_Pathology#Mast_Cell_Proliferation_Disorders|Mast cell tumours]] of the intestine, liver and skin.
 ==References==

@@ Line 2: / Line 2: @@
 [[Image:LH Mast cells Histology.jpg|right|thumb|150px|<p>'''Mast cells'''</p><sup>©Nottingham Uni 2008</sup>]]
 ==Introduction==
-<p>Mast cells are derived from the same stem cell line as [[Basophils|basophils]] and while they are similar to [[Basophils|basophils]] they are not identical. Mast cells are found in connective tissue and are larger than other [[Leukocytes|leukocytes]] at 15-20µm. They have cytoplasm containing a high number of large, intensely staining basophilic granules which mask the nucleus.</p>
+<p>Mast cells are derived from the same stem cell line as [[Basophils|basophils]] and while they are similar to basophils they are not identical. Mast cells are found in connective tissue and are larger than other [[Leukocytes|leukocytes]] at 15-20µm. They have cytoplasm containing a high number of large, intensely staining basophilic granules which mask the nucleus.</p>
 ==Development==
 <p>Mast cells CFU develops in the [[Bone Marrow - Anatomy & Physiology|bone marrow]] from the myeloid set cell ([[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]]) under the stimulation of IL-3 and Stem Cell Factor. Then under the stimulation of Il-6 and SCF the immature mast cells are formed. These then enter circulation where they remain undifferentiated. On migration into tissue they then differentiate, under stimulation by Il-4, and produce their granules. Once in the tissue mast cells may last for weeks to months.</p>