Normal Mechanisms of Haemostatic Control - Revision history

Bara at 16:18, 15 October 2013

2013-10-15T16:18:26Z

2011-02-14T14:55:27Z

Text replace - "[[Haemorrhage - Pathology" to "[[Haemorrhage"

2010-10-20T09:53:17Z

Introduction

2010-10-20T09:42:23Z

2010-09-29T10:37:32Z

Coagulation physiology

2010-09-29T10:37:06Z

Coagulation physiology

2010-09-29T10:36:54Z

Coagulation physiology

2010-09-29T10:34:50Z

Coagulation physiology

2010-09-29T10:34:02Z

Coagulation physiology

2010-09-29T09:55:59Z

Platelet Responses

← Older revision		Revision as of 16:18, 15 October 2013
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	[[Category:Haemostasis and Bleeding Disorders]]		[[Category:Haemostasis and Bleeding Disorders]]
		+	[[Category:Cardiology Section]]

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 ==Regulation of Coagulation==
-The blood coagulation process is beneficial, as it is designed to minimise blood loss, however, if the mechanism is prematurely or inadvertently triggered or fibrin deposition becomes excessive, the blood vessels may become obstructed. There is an inhibition system to guard against the   cascade being inappropriately triggered, and a mechanism to remove clots once their purpose has been achieved - fibrinolysis. Normally there is a dynamic equilibrium between clotting and fibrinolysis so that the vascular system is guarded from the two principal hazards - [[Haemorrhage - Pathology|haemorrhage]] and excessive clotting.
+The blood coagulation process is beneficial, as it is designed to minimise blood loss, however, if the mechanism is prematurely or inadvertently triggered or fibrin deposition becomes excessive, the blood vessels may become obstructed. There is an inhibition system to guard against the   cascade being inappropriately triggered, and a mechanism to remove clots once their purpose has been achieved - fibrinolysis. Normally there is a dynamic equilibrium between clotting and fibrinolysis so that the vascular system is guarded from the two principal hazards - [[Haemorrhage|haemorrhage]] and excessive clotting.
 ===Natural Inhibitors===

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 ==Introduction==
 Haemostasis is the normal spontaneous arrest of bleeding from ruptured blood vessels. Normal haemostasis depends on a combination of events: the  vascular response, which occurs mainly at capillary and small blood vessel level, the platelet (or [[Thrombocytes|thrombocyte]]) response, which also occurs in capillaries and small vessels, and the blood coagulation response which takes place in the arteries and veins.
 ==Vascular Responses==

← Older revision		Revision as of 09:42, 20 October 2010
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−	[[Category:Haemostasis\|A]]	+	[[Category:Haemostasis and Bleeding Disorders]]

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 ==Coagulation physiology==
-[[Image:2000px-Coagulation full svg.png|right|thumb|250px|<p>'''Coagulation Cascade''' Source: Wikimedia Commons; Author: Joe D (2007)</p>]]
+[[Image:2000px-Coagulation full svg.png|right|thumb|300px|<p>'''Coagulation Cascade''' Source: Wikimedia Commons. Author: Joe D (2007)</p>]]
 The process of blood coagulation is a cascade system involving a series of conversions of proenzymes to active forms. The amount and speed of conversion increases at each level. The major trigger for the system is contact activation.

← Older revision		Revision as of 10:34, 29 September 2010
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	==Coagulation physiology==		==Coagulation physiology==
		+
		+	[[Image:File:2000px-Coagulation full svg.png\|right\|thumb\|200px\|<p>'''Coagulation Cascade'''</p>]]
	The process of blood coagulation is a cascade system involving a series of conversions of proenzymes to active forms. The amount and speed of conversion increases at each level. The major trigger for the system is contact activation.		The process of blood coagulation is a cascade system involving a series of conversions of proenzymes to active forms. The amount and speed of conversion increases at each level. The major trigger for the system is contact activation.

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 ==Platelet Responses==
-Platelet responses are critical in maintaining haemostasis. When platelets are activated, the haemostatic plug is formed. Regulation by thrombosthenin gives clot organisation and fibrin formation; the clot continues to organise and contract over the 3-5 days following formation.
+Platelet responses are critical in maintaining haemostasis. When platelets are activated, the haemostatic plug is formed. Regulation by the contractile platelet protein thrombosthenin gives clot organisation and fibrin formation; the clot continues to organise and contract over the 3-5 days following formation. Thrombosthenin is present in platelet granules and in the platelet membrane.
 A series of events activates platelets to allow them to form the haemostatic plug: