Pancreatitis - Cat - Revision history

Bara at 21:15, 26 September 2012

2012-09-26T21:15:52Z

Bara at 12:34, 13 April 2011

2011-04-13T12:34:57Z

Bara: /* Introduction */

2011-03-25T19:13:18Z

Introduction

Bara at 19:12, 25 March 2011

2011-03-25T19:12:59Z

Bara at 18:52, 25 March 2011

2011-03-25T18:52:48Z

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2011-03-25T18:43:53Z

Bara at 18:19, 25 March 2011

2011-03-25T18:19:29Z

Bara: Created page with "==Introduction== See Pancreatitis for general overview of the disease. Cats mainly suffer from mild chronic interstitial pancreatitis. ==Signalment== Increased risk of dis..."

2011-03-25T18:13:20Z

Created page with "==Introduction== See Pancreatitis for general overview of the disease. Cats mainly suffer from mild chronic interstitial pancreatitis. ==Signalment== Increased risk of dis..."

New page

==Introduction==

See [[Pancreatitis]] for general overview of the disease.

Cats mainly suffer from mild chronic interstitial pancreatitis.

==Signalment==
Increased risk of disease occurs with obesity, [[Diabetes Mellitus|diabetes mellitus]], [[Hyperadrenocorticism|hyperadrenocorticalism]], prior gastrointestinal disease or [[Seizures|recurrent seizures]].

== Acute Pancreatitis in Cats ==

==== Introduction''' ''' ====

Cats occasionally get the acute necrotizing form seen in dogs, but acute interstitial pancreatitis in seen mainly with systemic toxoplasmosis. Cats mainly get chronic pancreatitis, rather than the acute form. Pyogranulomatous pancreatitis occurs in FIP. Serum amylase and lipase are unreliable (extrahepatic sources and both are excreted by the kidneys). There is usually a high serum glucose and cholesterol, with low serum potassium and calcium present on blood tests. Serum feline tryspin-like immunoreactivity is poorly associated with histopathological diagnosis. 

==== Clinical Signs ====

Signs are very vaue and may include vomiting, diarrhoea and anorexia. 

==== Diagnosis ====

In cats it is a much less common disease and so therefore more difficult to diagnose, especially as the clinical signs are so vague. In cats lipase, amylase and Serum trypsin-like immunoreactivity (TLI) have little value. Serum pancreatic lipase immunoreactivity (PLI) is usually raised and cPLI & fPLI look promising as sensitive and specific markers for pancreatic inflammation. 

==== Treatment ====

Do not starve cats. Intravenous fluid therapy is required and a feeding tube may be placed (risk of hepatic lipidosis if do not eat).

@@ Line 1: / Line 1: @@
 ==Introduction==
@@ Line 114: / Line 115: @@
-==Literature Search==
+{{Learning
-[[File:CABI logo.jpg|left|90px]]
+|literature search = [http://www.cabdirect.org/search.html?q=title%3A%28%22pancreatitis%22%29+AND+%28od%3A%28cats%29+OR+title%3A%28dogs%29%29&fq=sc%3A%22ve%22 Pancreatitis in cats and dogs publications]
+|full text = [http://www.cabi.org/cabdirect/FullTextPDF/2006/20063041204.pdf ''' Pancreatitis in cats.''' Graves, T. K.; Ontario Veterinary Medical Association, Milton, Canada, Ahead of the curve: OVMA Conference Proceedings, 26-28 January, 2006, 2006, pp 158-163]
+}}
 == References<br>  ==
@@ Line 147: / Line 151: @@
 [[Category:Pancreatic Diseases - Cat]][[Category:To Do - Review]]

@@ Line 16: / Line 16: @@
 [[Diarrhoea|Diarrhoea]] is also a common feature sometimes with blood, fresh or melaena this occurs due to the proximity of inflamed pancreas to the [[Duodenum - Anatomy & Physiology|duodenum]] and [[Colon - Anatomy & Physiology|colon]].
-More severe cases may present in [[Shock|shock]], [[Kidney Renal Failure - Pathology#Acute|acute renal failure]], [[Icterus|jaundiced]] (due to focal hepatic necrosis), or with cardiac arrhythmias. Pulmonary oedema, pleural effusions, widespread haemorrhage, [[Disseminated Intravascular Coagulation|DIC]], mild ascites, dehydration (mild to moderate) and pyrexia may also be present.
+More severe cases may present in [[Shock|shock]], [[Acute Renal Failure|acute renal failure]], [[Icterus|jaundiced]] (due to focal hepatic necrosis), or with cardiac arrhythmias. Pulmonary oedema, pleural effusions, widespread haemorrhage, [[Disseminated Intravascular Coagulation|DIC]], mild ascites, dehydration (mild to moderate) and pyrexia may also be present.
 A cranial abdominal mass may be palpated.
@@ Line 32: / Line 32: @@
 ====Pancreas-specific laboratory tests====
-All pancreatic enzymes increase following [[Kidney Renal Failure - Pathology|renal failure]] (apart from PLI) making it difficult to determine the true cause of the increase. However increases of three fold are mainly due to pancreatitis, whereas five fold increases are rarely not found to be pancreatitis. Rises in lipase, amylase and phospholipase A2 may also be hepatic, gastric, intestinal or neoplastic in origin.
+All pancreatic enzymes increase following [[:Category:Renal Failure|renal failure]] (apart from PLI) making it difficult to determine the true cause of the increase. However increases of three fold are mainly due to pancreatitis, whereas five fold increases are rarely not found to be pancreatitis. Rises in lipase, amylase and phospholipase A2 may also be hepatic, gastric, intestinal or neoplastic in origin.
 '''In cats:''' Amylase and lipase are of no diagnostic value. Serum feline trypsin-like immunoreactivity (fTLI) is a specific test for exocrine pancreatic function but the test's sensitivity varies between 30% and 60%. In comparison, the serum feline pancreatic lipase immunoreactivity test (fPLI) has been found to be more specific and sensitive in diagnosing feline pancreatitis.

@@ Line 5: / Line 5: @@
 Cats mainly suffer from mild chronic interstitial pancreatitis.
-==General Disease]]
+==General Disease==
 ===Signalment===
@@ Line 74: / Line 74: @@
 ===Prognosis===
 The disease varies widely and the prognosis can vary from full recovery to death. Generally if the case is an uncomplicated single episode patients will make a good recovery.
 == Acute Pancreatitis ==

@@ Line 5: / Line 5: @@
 Cats mainly suffer from mild chronic interstitial pancreatitis.
-==Signalment==
+==General Disease]]
 Increased risk of disease occurs with obesity, [[Diabetes Mellitus|diabetes mellitus]], [[Hyperadrenocorticism|hyperadrenocorticalism]], prior gastrointestinal disease or [[Seizures|recurrent seizures]].
-==History and Clinical Signs==
+===History and Clinical Signs===
 There is often a history of eating a fatty meal.
@@ Line 15: / Line 17: @@
 [[Diarrhoea|Diarrhoea]] is also a common feature sometimes with blood, fresh or melaena this occurs due to the proximity of inflamed pancreas to the [[Duodenum - Anatomy & Physiology|duodenum]] and [[Colon - Anatomy & Physiology|colon]].
 More severe cases may present in [[Shock|shock]], [[Kidney Renal Failure - Pathology#Acute|acute renal failure]], [[Icterus|jaundiced]] (due to focal hepatic necrosis), or with cardiac arrhythmias. Pulmonary oedema, pleural effusions, widespread haemorrhage, [[Disseminated Intravascular Coagulation|DIC]], mild ascites, dehydration (mild to moderate) and pyrexia may also be present.
 A cranial abdominal mass may be palpated.
@@ Line 22: / Line 22: @@
 Affected '''cats''' have a very varied presentation. If severe, they present with lethargy and anorexia with vomiting and abdominal pain being reported less than in the dog, hypothermia is also common sign occurring in 68% of affected cats. Mild chronic pancreatitis may show anorexia and weight loss.
-==Laboratory Tests==
+===Laboratory Tests===
 On Haematology there may be a leucocytosis, an increased [[Packed Cell Volume]] due to dehydration, [[Platelet Abnormalities#Thrombocytopaenia|thrombocytopaenia]], [[Neutrophilia|neutrophilia]] and a left shift.
@@ Line 31: / Line 31: @@
 An increase in pancreatic digestive enzymes (amylase, lipase, trypsin-like immunoreactivity (TLI), phospholipase A2 and pancreatic lipase immunoreactivity (PLI) will also be present.
-===Pancreas-specific laboratory tests===
+====Pancreas-specific laboratory tests====
 All pancreatic enzymes increase following [[Kidney Renal Failure - Pathology|renal failure]] (apart from PLI) making it difficult to determine the true cause of the increase. However increases of three fold are mainly due to pancreatitis, whereas five fold increases are rarely not found to be pancreatitis. Rises in lipase, amylase and phospholipase A2 may also be hepatic, gastric, intestinal or neoplastic in origin.
 '''In cats:''' Amylase and lipase are of no diagnostic value. Serum feline trypsin-like immunoreactivity (fTLI) is a specific test for exocrine pancreatic function but the test's sensitivity varies between 30% and 60%. In comparison, the serum feline pancreatic lipase immunoreactivity test (fPLI) has been found to be more specific and sensitive in diagnosing feline pancreatitis.
-'''In dogs:''' Marked increases in serum lipase is a more reliable marker than amylase. However corticosteroid administration raises lipase activity by up to five fold. Serum canine pancreatic lipase immunoreactivity (cPLI) is the most sensitive and specific test for diagnosing canine pancreatitis.
+===Diagnostic Imaging===
 '''Survey Radiographs''' are rarely helpful but findings may include an increased density in the right cranial abdomen, decreased contrast, decreased granularity and the stomach may be displaced to the left.
 Additionally the descending duodenum may be displaced to the right, with the presence of a medial mass and thickened walls.
@@ Line 48: / Line 46: @@
 pancreatic enlargement, peritoneal effusion, hypoechogenic pancreas (pancreatic necrosis) and hyperechogenic surrounding tissue.
-==Exploratory Laparotomy/Necropsy Findings==
+===Exploratory Laparotomy/Necropsy Findings===
 The pancreas will be oedematous and soft with fibrinous attachments to surrounding organs, there may be free fluid within the peritoneal cavity and pancreas liquefaction if severe enough.
 Pseudocysts may be present, as well as omental and pancreatic [[Haemorrhage|haemorrhages]] and areas of fat necrosis.
@@ Line 54: / Line 52: @@
 A biopsy should be taken to provide evidence of inflammation.
-==Treatment==
+===Treatment===
-===Acute Treatment===
+====Acute Treatment====
 The general treatment involves fluid correction and maintenance while any underlying cause is treated. Support is then given to allow the inflammatory process to subside. Oral feeding should be witheld for a short period in vomiting patients but enteral and parenteral feeding can be well tolerated.
@@ Line 71: / Line 69: @@
 For short term use in fulminating pancreatitis, [[Steroids|corticosteroids]] can be given alongside fluids. Long term treatment may lead to unwanted complications.
-===Long-term treatment===
+====Long-term treatment====
 In most patients that have one episode, they may only need to avoid fatty foods. Recurrent hypertriglyceridaemia may need pharmacological intervention.
-==Prognosis==
+===Prognosis===
 The disease varies widely and the prognosis can vary from full recovery to death. Generally if the case is an uncomplicated single episode patients will make a good recovery.
-== Acute Pancreatitis in Cats<br>  ==
+== Acute Pancreatitis ==
-==== Introduction'''<br>'''  ====
+==== Introduction  ====
 Cats occasionally get the acute necrotizing form seen in dogs, but acute interstitial pancreatitis in seen mainly with systemic toxoplasmosis. Cats mainly get chronic pancreatitis, rather than the acute form. Pyogranulomatous pancreatitis occurs in FIP. Serum amylase and lipase are unreliable (extrahepatic sources and both are excreted by the kidneys). There is usually a high serum glucose and cholesterol, with low serum potassium and calcium present on blood tests. Serum feline tryspin-like immunoreactivity is poorly associated with histopathological diagnosis.<br>
-==== Clinical Signs<br>  ====
+==== Clinical Signs  ====
-Signs are very vaue and may include vomiting, diarrhoea and anorexia. <br>
+Signs are very vaue and may include vomiting, diarrhoea and anorexia. <br> '''Acute haemorrhagic pancreatitis''' may present as shock and collapse.
-==== Diagnosis<br>  ====
+==== Diagnosis  ====
 In cats it is a much less common disease and so therefore more difficult to diagnose, especially as the clinical signs are so vague. In cats lipase, amylase and Serum trypsin-like immunoreactivity (TLI) have little value. Serum pancreatic lipase immunoreactivity (PLI) is usually raised and cPLI &amp; fPLI look promising as sensitive and specific markers for pancreatic inflammation.<br>
-==== Treatment<br>  ====
+==== Treatment  ====
 Do not starve cats. Intravenous fluid therapy is required and a feeding tube may be placed (risk of hepatic lipidosis if do not eat). <br>
@@ Line 98: / Line 96: @@
 <br>
-== Chronic Pancreatitis in Cats<br> ==
+== Chronic Pancreatitis ==
 [http://w3.vet.cornell.edu/nst/nst.asp?Fun=Image&imgID=6937 Image of chronic pancreatitis and fibrosis in a cat from Cornell Veterinary Medicine]
@@ Line 104: / Line 102: @@
 This chronic, relapsing condition is more common than the acute condition in cats. Fibrosis, ductular ectasia with cyst formation and inflammation will be present on the pancreas. The condition has been associated with hepatic lipidosis, cholangiohepatitis and inflammatory bowel disease. <br>
-==== Clinical Signs<br> ====
+==== Clinical Signs ====
 Clinical signs are vague and may include vomiting, diarrhoea, anorexia, lethargy and icterus.<br>
-==== Diagnosis<br> ====
+==== Diagnosis ====
 Blood tests for lipase may be normal or elevated in cats and therfore may or may not be any use. Amylase and Serum trypsin-like immunoreactivity (TLI) are not useful in cats. Serum pancreatic lipase immunoreactivity (PLI) will be raised and cPLI &amp; fPLI look promising as sensitive and specific markers for pancreatic inflammation.<br>
-==== Treatment<br> ====
+==== Treatment ====
 ==Literature Search==
 [[File:CABI logo.jpg|left|90px]]
@@ Line 148: / Line 146: @@
 Tilley, L.P. and Smith, F.W.K.(2004) '''The 5-minute Veterinary Consult''' (Third edition) Lippincott, ''Williams & Wilkins''

← Older revision		Revision as of 18:52, 25 March 2011
Line 53:		Line 53:

	A biopsy should be taken to provide evidence of inflammation.		A biopsy should be taken to provide evidence of inflammation.
		+
		+	==Treatment==
		+	===Acute Treatment===
		+	The general treatment involves fluid correction and maintenance while any underlying cause is treated. Support is then given to allow the inflammatory process to subside. Oral feeding should be witheld for a short period in vomiting patients but enteral and parenteral feeding can be well tolerated.
		+
		+	Analgesia should always be given even without signs of pain. Recommended options include subcutaneous [[Opioids#Pethidine\|pethidine]], intravenous or continuous rate infusion [[Opioids#Morphine\|morphine]] or transdermal [[Opioids#Fentanyl\|fentanyl]]. Dogs can also be given intraperitoneal [[Local Anaesthetics#Lidocaine\|lidocaine]] or [[Local Anaesthetics#Bupivicaine\|bupivicaine]].
		+
		+	If a pancreatic infection is suspected then [[Antibiotics\|antibiotics]] should be administered, [[Potentiated-Sulphonamides\|trimethoprim-sulphonamide]] and [[Fluoroquinolones\|enrofloxacin]] have good penetration to the pancreas.
		+
		+	Food can be gradually introduced with a low protein and fat content as these are more likely to cause signs. Fat can be further introduced if symptoms have still not returned. If signs reoccur then further starvation should be carried out. Total parenteral nutrition can be used to sustain animals that are unable to tolerate food at all.
		+
		+	Cases often require supportive care, aggressive [[Principles of Fluid Therapy\|fluid therapy]] will be needed to treat dehydration and fluid loss from [[Diarrhoea\|diarrhoea]] and vomiting. Renal function and potassium levels should be monitored and if necessary potassium should be supplemented.
		+	Patients may also develop a metabolic acidosis in acute pancreatitis or be alkalotic due to vomiting. Should [[Diabetes Mellitus\|diabetes mellitus]] develop, this may require treatment with insulin. Further management may be required for respiratory distress, bleeding disorders, renal failure, cardiovascular problems and neurological disorders.
		+
		+	Additionally a whole blood or plasma transfusion can be given with severe disease to replace α-macroglobulins. Albumin also provides oncotic support and limits pancreatic ischaemia and oedema.
		+
		+	For short term use in fulminating pancreatitis, [[Steroids\|corticosteroids]] can be given alongside fluids. Long term treatment may lead to unwanted complications.
		+
		+	===Long-term treatment===
		+	In most patients that have one episode, they may only need to avoid fatty foods. Recurrent hypertriglyceridaemia may need pharmacological intervention.
		+
		+	==Prognosis==
		+	The disease varies widely and the prognosis can vary from full recovery to death. Generally if the case is an uncomplicated single episode patients will make a good recovery.
		+

	== Acute Pancreatitis in Cats<br> ==		== Acute Pancreatitis in Cats<br> ==

← Older revision		Revision as of 18:19, 25 March 2011
Line 28:		Line 28:

	<br>		<br>
		+
		+	== Chronic Pancreatitis in Cats<br> ==
		+
		+	[http://w3.vet.cornell.edu/nst/nst.asp?Fun=Image&imgID=6937 Image of chronic pancreatitis and fibrosis in a cat from Cornell Veterinary Medicine]
		+
		+	This chronic, relapsing condition is more common than the acute condition in cats. Fibrosis, ductular ectasia with cyst formation and inflammation will be present on the pancreas. The condition has been associated with hepatic lipidosis, cholangiohepatitis and inflammatory bowel disease. <br>
		+
		+	==== Clinical Signs<br> ====
		+
		+	Clinical signs are vague and may include vomiting, diarrhoea, anorexia, lethargy and icterus.<br>
		+
		+	==== Diagnosis<br> ====
		+
		+	Blood tests for lipase may be normal or elevated in cats and therfore may or may not be any use. Amylase and Serum trypsin-like immunoreactivity (TLI) are not useful in cats. Serum pancreatic lipase immunoreactivity (PLI) will be raised and cPLI & fPLI look promising as sensitive and specific markers for pancreatic inflammation.<br>
		+
		+	==== Treatment<br> ====
		+
		+	Treat the underlying cause if there is one. Treatment may include placing the animal on a low fat diet and giving supportive care such as fluids and analgesia. If the cat is not eating, place a feeding tube as starvation may cause hepatic lipidosis in cats.<br>
		+
		+	<br>
		+
		+	== References<br> ==
		+
		+	Blood, D.C. and Studdert, V. P. (1999) Saunders Comprehensive Veterinary Dictionary (2nd Edition) Elsevier Science<br>Cowart, R.P. and Casteel, S.W. (2001) An Outline of Swine diseases: a handbook Wiley-Blackwell<br>Ettinger, S.J. and Feldman, E. C. (2000) Textbook of Veterinary Internal Medicine Diseases of the Dog and Cat Volume 2 (Fifth Edition) W.B. Saunders Company<br>Ettinger, S.J, Feldman, E.C. (2005) Textbook of Veterinary Internal Medicine (6th edition, volume 2)W.B. Saunders Company<br>Fossum, T. W. et. al. (2007) Small Animal Surgery (Third Edition) Mosby Elsevier<br>Jackson, G.G. and Cockcroft, P.D. (2007) Handbook of Pig Medicine Saunders Elsevier<br>Knottenbelt, D.C. A Handbook of Equine Medicine for Final Year Students University of Liverpool<br>Merck & Co (2008) The Merck Veterinary Manual (Eighth Edition) Merial<br>Nelson, R.W. and Couto, C.G. (2009) Small Animal Internal Medicine (Fourth Edition) Mosby Elsevier.<br>Sturgess, K. (2003) Notes on Feline Internal Medicine Blackwell Publishing. <br>