Paramyxoviridae - Overview - Revision history

DrNdaba: /* Types and Subtypes */

2018-05-31T08:41:58Z

Types and Subtypes

Bara at 16:47, 18 July 2012

2012-07-18T16:47:35Z

Bara at 13:53, 30 June 2011

2011-06-30T13:53:40Z

Bara: /* Introduction */

2011-04-20T22:15:46Z

Introduction

Bara at 22:15, 20 April 2011

2011-04-20T22:15:13Z

Kthompson at 14:00, 19 April 2011

2011-04-19T14:00:58Z

Bara at 16:33, 18 August 2010

2010-08-18T16:33:17Z

Bara: Created page with "The Paramyxoviridae have a helical nucleocapsid surrounded by an envelope comprised of host cell membrance spiked with viral glycoproteins responsible for haemagglutinin, neurami..."

2010-08-18T16:32:48Z

Created page with "The Paramyxoviridae have a helical nucleocapsid surrounded by an envelope comprised of host cell membrance spiked with viral glycoproteins responsible for haemagglutinin, neurami..."

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The Paramyxoviridae have a helical nucleocapsid surrounded by an envelope comprised of host cell membrance spiked with viral glycoproteins responsible for haemagglutinin, neuraminidase and haemolytic activities. The genome of the Paramyxoviridae is single-stranded, negative-sense RNA which is used as a template for the production of messenger (positive-sense) RNA and further genomic material. Paramyxoviridae are sensitive to heat, dessication and most disinfectants, and so are not resistant in the environment. The Paramyxovididae family is divided to two sub-families, the Paramyxovirinae and the Pneumovirinae. It is within the Paramyxovirinae sub-family that morbilliviruses fall, along with respiroviruses, henipaviruses, rubulaviruses and avulaviruses. As well as canine distemper virus (CDV), the morbilliviruses include rinderpest, peste de petits ruminants, measles, phocine distemper and dolphin distemper.

==Morphology==
*Single-stranded negative-sense unsegmented RNA virus
*Reassortment and antigenic shift cannot occur
*Spike proteins include
**'''HN''' (Haemagglutinin and Neuraminidase)
**'''F''' (Fusion glycoprotein), which allows the virus to fuse directly to the plasma membrane and release its RNA
***F also causes syncitium to form, which aids diagnosis
***Host antibody response to the F protein is the basis for vaccination

==Virulence==
*Paramyxoviruses replicate in the epithelium of the upper respiratory tract as well as occasionally in the gut
**Sites of spike protein cleavage
*Virulence varies by virus, see below

==Types and Subtypes==
Paramoyxoviridae was reclassified in 2000 to include 2 subfamilies and 5 genera, of interest including:
*Subfamily: ''[[Paramyxovirinae]]'':

*Subfamily: ''[[Pneumovirinae]]''

==Antigenic Variation==
*Antigenic conservation allows some cross protection by vaccination:
**Conservation of major virus-specific F/HN antigens means vaccines protect against '''all isolates''' of the same virus
**Minor morbillivirus-specific epitopes on F allows some cross protection between '''canine distemper, measles, and rinderpest'''
*Antigenic "fingerprinting" is possible for some viruses based on minor variable epitopes of HN, F and NP on specific isolates as detected by monoclonal antibodies
**These are detected by immunostaining infected cells

=Other resources=
*[http://www.pitt.edu/~super1/lecture/lec3401/index.htm On line Paramyxoviridae lecture by P. Russell]
[[Category:To_Do_-_Clinical/Viruses]]
[[Category:Paramyxoviridae]]

@@ Line 12: / Line 12: @@
 ==Types and Subtypes==
-Paramoyxoviridae was reclassified in 2000 to include 2 subfamilies and 5 genera, of interest including the subfamily ''[[Paramyxovirinae]]'' and subfamily ''[[Pneumovirinae]]''.
+Paramyxoviridae was reclassified in 2000 to include 2 subfamilies and 5 genera, of interest including the subfamily ''[[Paramyxovirinae]]'' and subfamily ''[[Pneumovirinae]]''.
 ==Antigenic Variation==

@@ Line 1: / Line 1: @@
 ==Introduction==
 The Paramyxoviridae have a helical nucleocapsid surrounded by an envelope comprised of host cell membrane spiked with viral glycoproteins responsible for haemagglutinin, neuraminidase and haemolytic activities. The genome of the Paramyxoviridae is single-stranded, negative-sense RNA which is used as a template for the production of messenger (positive-sense) RNA and further genomic material. Paramyxoviridae are sensitive to heat, dessication and most disinfectants, and so are not resistant in the environment. The Paramyxovididae family is divided to two sub-families, the [[Paramyxovirinae]] and the [[Pneumovirinae]]. It is within the Paramyxovirinae sub-family that [[morbilliviruses]] fall, along with respiroviruses, henipaviruses, rubulaviruses and avulaviruses. As well as [[Canine Distemper Virus|canine distemper virus (CDV)]], the morbilliviruses include [[rinderpest]], [[Peste des Petits Ruminants|peste des petits ruminants]], measles, phocine (seal) distemper and dolphin distemper.
@@ Line 24: / Line 25: @@
 {{review}}
 [[Category:Expert_Review]]
 [[Category:Paramyxoviridae|A]]

@@ Line 19: / Line 19: @@
 Antigenic "fingerprinting" is possible for some viruses based on minor variable epitopes of HN, F and NP on specific isolates as detected by monoclonal antibodies. These are detected by immunostaining infected cells.
-=Other resources=
+==Other resources==
 *[http://www.pitt.edu/~super1/lecture/lec3401/index.htm On line Paramyxoviridae lecture by P. Russell]
@@ Line 25: / Line 25: @@
 {{review}}
 [[Category:Expert_Review]]
-[[Category:Paramyxoviridae]]
+[[Category:Paramyxoviridae|A]]

@@ Line 1: / Line 1: @@
 ==Introduction==
-The Paramyxoviridae have a helical nucleocapsid surrounded by an envelope comprised of host cell membrane spiked with viral glycoproteins responsible for haemagglutinin, neuraminidase and haemolytic activities. The genome of the Paramyxoviridae is single-stranded, negative-sense RNA which is used as a template for the production of messenger (positive-sense) RNA and further genomic material. Paramyxoviridae are sensitive to heat, dessication and most disinfectants, and so are not resistant in the environment. The Paramyxovididae family is divided to two sub-families, the [[Paramyxovirinae]] and the [[Pneumovirinae]]. It is within the Paramyxovirinae sub-family that [[morbilliviruses]] fall, along with respiroviruses, henipaviruses, rubulaviruses and avulaviruses. As well as [[Canine Distemper VirusZcanine distemper virus (CDV)]], the morbilliviruses include [[rinderpest]], [[Peste des Petit Ruminants|peste des petits ruminants]], measles, phocine (seal) distemper and dolphin distemper.
+The Paramyxoviridae have a helical nucleocapsid surrounded by an envelope comprised of host cell membrane spiked with viral glycoproteins responsible for haemagglutinin, neuraminidase and haemolytic activities. The genome of the Paramyxoviridae is single-stranded, negative-sense RNA which is used as a template for the production of messenger (positive-sense) RNA and further genomic material. Paramyxoviridae are sensitive to heat, dessication and most disinfectants, and so are not resistant in the environment. The Paramyxovididae family is divided to two sub-families, the [[Paramyxovirinae]] and the [[Pneumovirinae]]. It is within the Paramyxovirinae sub-family that [[morbilliviruses]] fall, along with respiroviruses, henipaviruses, rubulaviruses and avulaviruses. As well as [[Canine Distemper Virus|canine distemper virus (CDV)]], the morbilliviruses include [[rinderpest]], [[Peste des Petits Ruminants|peste des petits ruminants]], measles, phocine (seal) distemper and dolphin distemper.
 ==Morphology==

@@ Line 1: / Line 1: @@
 ==Introduction==
-The Paramyxoviridae have a helical nucleocapsid surrounded by an envelope comprised of host cell membrance spiked with viral glycoproteins responsible for haemagglutinin, neuraminidase and haemolytic activities. The genome of the Paramyxoviridae is single-stranded, negative-sense RNA which is used as a template for the production of messenger (positive-sense) RNA and further genomic material. Paramyxoviridae are sensitive to heat, dessication and most disinfectants, and so are not resistant in the environment. The Paramyxovididae family is divided to two sub-families, the Paramyxovirinae and the Pneumovirinae. It is within the Paramyxovirinae sub-family that morbilliviruses fall, along with respiroviruses, henipaviruses, rubulaviruses and avulaviruses. As well as canine distemper virus (CDV), the morbilliviruses include rinderpest, peste de petits ruminants, measles, phocine distemper and dolphin distemper.
+The Paramyxoviridae have a helical nucleocapsid surrounded by an envelope comprised of host cell membrane spiked with viral glycoproteins responsible for haemagglutinin, neuraminidase and haemolytic activities. The genome of the Paramyxoviridae is single-stranded, negative-sense RNA which is used as a template for the production of messenger (positive-sense) RNA and further genomic material. Paramyxoviridae are sensitive to heat, dessication and most disinfectants, and so are not resistant in the environment. The Paramyxovididae family is divided to two sub-families, the [[Paramyxovirinae]] and the [[Pneumovirinae]]. It is within the Paramyxovirinae sub-family that [[morbilliviruses]] fall, along with respiroviruses, henipaviruses, rubulaviruses and avulaviruses. As well as [[Canine Distemper VirusZcanine distemper virus (CDV)]], the morbilliviruses include [[rinderpest]], [[Peste des Petit Ruminants|peste des petits ruminants]], measles, phocine (seal) distemper and dolphin distemper.
 ==Morphology==
 The virus is constructed of single-stranded negative-sense unsegmented RNA. Reassortment and antigenic shift cannot occur with this virus.
-<br>
 Spike proteins include '''HN''' (Haemagglutinin and Neuraminidase) and '''F''' (Fusion glycoprotein), which allows the virus to fuse directly to the plasma membrane and release its RNA. F also causes syncitium to form, which aids diagnosis. The host antibody response to the F protein is the basis for vaccination.
 ==Virulence==
 Paramyxoviruses replicate in the epithelium of the upper respiratory tract as well as occasionally in the gut as these are sites of spike protein cleavage. Virulence varies by virus, see below.
 ==Types and Subtypes==
 Paramoyxoviridae was reclassified in 2000 to include 2 subfamilies and 5 genera, of interest including the subfamily ''[[Paramyxovirinae]]'' and subfamily ''[[Pneumovirinae]]''.
 ==Antigenic Variation==
 Antigenic conservation allows some cross protection by vaccination as conservation of major virus-specific F/HN antigens means vaccines protect against '''all isolates''' of the same virus.
 Minor morbillivirus-specific epitopes on F allows some cross protection between '''canine distemper, measles, and rinderpest'''.
-<br>
 Antigenic "fingerprinting" is possible for some viruses based on minor variable epitopes of HN, F and NP on specific isolates as detected by monoclonal antibodies. These are detected by immunostaining infected cells.
 =Other resources=
 *[http://www.pitt.edu/~super1/lecture/lec3401/index.htm On line Paramyxoviridae lecture by P. Russell]
-[[Category:To_Do_-_Review]]
 [[Category:Paramyxoviridae]]

← Older revision		Revision as of 16:33, 18 August 2010
Line 1:		Line 1:
		+	==Introduction==
	The Paramyxoviridae have a helical nucleocapsid surrounded by an envelope comprised of host cell membrance spiked with viral glycoproteins responsible for haemagglutinin, neuraminidase and haemolytic activities. The genome of the Paramyxoviridae is single-stranded, negative-sense RNA which is used as a template for the production of messenger (positive-sense) RNA and further genomic material. Paramyxoviridae are sensitive to heat, dessication and most disinfectants, and so are not resistant in the environment. The Paramyxovididae family is divided to two sub-families, the Paramyxovirinae and the Pneumovirinae. It is within the Paramyxovirinae sub-family that morbilliviruses fall, along with respiroviruses, henipaviruses, rubulaviruses and avulaviruses. As well as canine distemper virus (CDV), the morbilliviruses include rinderpest, peste de petits ruminants, measles, phocine distemper and dolphin distemper.		The Paramyxoviridae have a helical nucleocapsid surrounded by an envelope comprised of host cell membrance spiked with viral glycoproteins responsible for haemagglutinin, neuraminidase and haemolytic activities. The genome of the Paramyxoviridae is single-stranded, negative-sense RNA which is used as a template for the production of messenger (positive-sense) RNA and further genomic material. Paramyxoviridae are sensitive to heat, dessication and most disinfectants, and so are not resistant in the environment. The Paramyxovididae family is divided to two sub-families, the Paramyxovirinae and the Pneumovirinae. It is within the Paramyxovirinae sub-family that morbilliviruses fall, along with respiroviruses, henipaviruses, rubulaviruses and avulaviruses. As well as canine distemper virus (CDV), the morbilliviruses include rinderpest, peste de petits ruminants, measles, phocine distemper and dolphin distemper.