Polypeptide Antibiotics - Revision history

Kitnmre at 02:42, 23 May 2016

2016-05-23T02:42:52Z

2009-08-20T16:17:15Z

Side Effects and Contraindications

2009-08-20T15:59:31Z

Mechanism of Action

2008-10-24T08:49:33Z

2008-10-24T08:49:07Z

Side Effects and Contraindications

2008-10-24T08:48:21Z

Spectrum of Activity

2008-10-24T08:47:46Z

Mechanism of Action

2008-10-23T15:41:36Z

2008-10-23T15:37:45Z

Mechanism of Action

2008-10-23T15:36:04Z

← Older revision		Revision as of 02:42, 23 May 2016
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	* In man it has been known to be neurotoxic and have neuromuscular blocking effects.		* In man it has been known to be neurotoxic and have neuromuscular blocking effects.
	* If sulphate salts are used in the drug preperation, pain and necrosis can occur at the injection site.		* If sulphate salts are used in the drug preperation, pain and necrosis can occur at the injection site.
		+
		+	{{Learning
		+	\|Vetstream = [https://www.vetstream.com/canis/Content/Generic/gen00589.asp Polymyxin B]}}

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 * Systemic use can lead to nephrotoxicity, especially in dogs.
 * '''Must not use in renal failure patients''' - as will accumulate in the kidney.
-* In man it has been known to be neurotoxix and have neuromuscular blocking effects.
+* In man it has been known to be neurotoxic and have neuromuscular blocking effects.
 * If sulphate salts are used in the drug preperation, pain and necrosis can occur at the injection site.

@@ Line 17: / Line 17: @@
 This group of antibiotics function by binding to the cell membrane and then making it permeable. This will lead to swelling of the cell and then apoptosis, resulting in the antibiotic being very bactericidal and a concentration dependent killer. As they are cationic basic proteins they also act like detergents.
-This group of antiobiotics also have another interesting function; they are capable of binding to bacterial endotoxin (LPS) and therefore neutralise. It is this secondary function, which is often why vets use these antibiotic as they are very useful in treating animals with '''endotoxic shock'''.
+This group of antibiotics also have another interesting function; they are capable of binding to bacterial endotoxin (LPS) and therefore neutralising it. It is this secondary function, which is often why vets use these antibiotic as they are very useful in treating animals with '''endotoxic shock'''.
 ==Spectrum of Activity==

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-{{unfinished}}
+{{review}}
 {{toplink
 |linkpage =WikiDrugs

@@ Line 38: / Line 38: @@
 * Systemic use can lead to nephrotoxicity, especially in dogs.
 * '''Must not use in renal failure patients''' - as will accumulate in the kidney.
 * If sulphate salts are used in the drug preperation, pain and necrosis can occur at the injection site.

@@ Line 25: / Line 25: @@
 * Action is potentiated by cationic detergents (Chlorohexidine) and by chelating agents (EDTA).
 * Have a synergistic action with other antibiotics that are able to penetrate the cell wall of gram negatives.
-* Their actio is inhibited by the presence of cell debris (pus) and divalent cations.
+* Their action is inhibited by the presence of cell debris (pus) and divalent cations.
+* Able to neutralise bacterial endotoxin.
 ==Pharmacokinetic Considerations==

@@ Line 15: / Line 15: @@
 ==Mechanism of Action==
-Look in text book.....Endotoxins etc....
+This group of antibiotics function by binding to the cell membrane and then making it permeable. This will lead to swelling of the cell and then apoptosis, resulting in the antibiotic being very bactericidal and a concentration dependent killer. As they are cationic basic proteins they also act like detergents.
-Very bactericidal, concentration dependent
+This group of antiobiotics also have another interesting function; they are capable of binding to bacterial endotoxin (LPS) and therefore neutralise. It is this secondary function, which is often why vets use these antibiotic as they are very useful in treating animals with '''endotoxic shock'''.
 ==Spectrum of Activity==

← Older revision		Revision as of 15:41, 23 October 2008
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−	[[Image: Polymyxin B.png\|thumb\|right\|250px\|The Core Structure of Polymyxin B (~~Cpoyright~~ WikiMedia Commons)]]	+	[[Image: Polymyxin B.png\|thumb\|right\|250px\|The Core Structure of Polymyxin B (Copyright WikiMedia Commons)]]

	This type of antibiotic are basic cyclic decapeptides. The commonly used drugs are '''Polymyxin B and E (Colistin)'''.		This type of antibiotic are basic cyclic decapeptides. The commonly used drugs are '''Polymyxin B and E (Colistin)'''.

← Older revision		Revision as of 15:37, 23 October 2008
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	Look in text book.....Endotoxins etc....		Look in text book.....Endotoxins etc....

		+	Very bactericidal, concentration dependent

	==Spectrum of Activity==		==Spectrum of Activity==