Recognition of Microorganisms - Revision history

Rjfrancisrvc: /* Pattern Recognition Receptors */

2012-05-23T11:06:29Z

Pattern Recognition Receptors

2012-05-23T11:05:49Z

Pattern Recognition Receptors

2012-05-23T11:04:46Z

Pattern Recognition Receptors

2012-05-23T10:58:14Z

Pattern Recognition Receptors

2012-05-23T10:52:28Z

2012-05-23T10:51:36Z

2012-05-23T10:47:47Z

2012-05-19T14:34:31Z

Pattern Recognition Receptors

2012-05-19T14:34:16Z

2012-05-10T11:35:59Z

@@ Line 65: / Line 65: @@
 | ds RNA of RNA viruses
 |}
-<p> For more information on Toll-like receptors see this review <ref>{{citation|initiallast = Lee|initialfirst = C.C.|2last = Avalos|2first = A.M.|finallast = Ploegh|finalfirst = H.L.|year = 2012|jtitle = Accessory molecules for Toll-like receptors and their function
+<p> For more information on Toll-like receptors see this review <ref>{{citation|initiallast = Lee|initialfirst = C.C|2last = Avalos|2first = A.M|finallast = Ploegh|finalfirst = H.L|year = 2012|jtitle = Accessory molecules for Toll-like receptors and their function
 |jor = Nature Reviews Immunology|vol = 12|range = 168-179}}</ref></p>
 <br><br>
 ==References==
 <references />

@@ Line 67: / Line 67: @@
 <p> For more information on Toll-like receptors see this review <ref>{{citation|initiallast = Lee|initialfirst = C.C.|2last = Avalos|2first = A.M.|finallast = Ploegh|finalfirst = H.L.|year = 2012|jtitle = Accessory molecules for Toll-like receptors and their function
 |jor = Nature Reviews Immunology|vol = 12|range = 168-179}}</ref></p>
-<br><br>,
+<br><br>
 {{Robert J Francis
 |date = May 10, 2012}}

@@ Line 65: / Line 65: @@
 | ds RNA of RNA viruses
 |}
-<br><br>
+<p> For more information on Toll-like receptors see this review <ref>{{citation|initiallast = Lee|initialfirst = C.C.|2last = Avalos|2first = A.M.|finallast = Ploegh|finalfirst = H.L.|year = 2012|jtitle = Accessory molecules for Toll-like receptors and their function
 {{Robert J Francis
 |date = May 10, 2012}}

@@ Line 30: / Line 30: @@
 |-
 | TLR3
-| Cell Membrane
+| Cell Membrane (in Endosome)
 | dsRNA of RNA viruses (e.g. avian influenza)
 |-
@@ Line 42: / Line 42: @@
 |-
 | TLR9
-| Cell Membrane
+| Cell Membrane (in Endosome)
 | Bacterial DNA (CpG DNA)
 |-

@@ Line 4: / Line 4: @@
 *Peptidoglycans of gram-positive bacteria
 *Mannose sugars
-*D-isoform amino acids (abundant in Peptidoglycans) - almost all (>99%) amino acids in multicellular organisms are the L-isoform of amino acids as it is only the L-isofrom amino acids that are used for protein synthesis.
+*D-isoform amino acids (abundant in Peptidoglycans) - almost all (>99%) amino acids in multicellular organisms are the L-isoform of amino acids as it is only the L-isoform amino acids that are used for protein synthesis.
 <br />
 These are known to the body as foreign as they are expressed as '''pathogen-associated molecular patterns''' (PAMPs) which are recognised by '''pattern recognition receptors''' (PRRs) expressed on mammalian cells. These receptors are expressed on many different cell types, not just on phagocytes, though not all are expressed by all cells: different cell types express a different range of PRRs. PRRs are either intracellular, membrane-associated or soluble:

← Older revision		Revision as of 14:34, 19 May 2012
Line 71:		Line 71:

	[[Category:Innate Immune System]]		[[Category:Innate Immune System]]
−	[[Category:Robert J Francis]]	+	[[Category:Robert J Francis reviewed]]

@@ Line 1: / Line 1: @@
 [[Image:PRRs.jpg|thumb|right|150px|Pattern Recognition Receptors - B. Catchpole, RVC 2008]]
-The innate immune system recognises components of pathogens which are intrinsically foreign (i.e. not present on normal mammalian cells), such as:
+The [[Innate Immune System - Introduction|innate immune system]] recognises components of pathogens which are intrinsically foreign (i.e. not present on normal mammalian cells), such as:
-*Lipopolysaccharides of gram-negative bacteria
+*Lipopolysaccharides of gram-negative [[bacteria]]
 *Peptidoglycans of gram-positive bacteria
 *Mannose sugars
@@ Line 13: / Line 13: @@
 The engagement of PRRs by PAMPs triggers:
 * '''[[Phagocytosis|Phagocytosis]]'''
-* The expression of '''[[Cytokines|cytokines]]''', which brings about [[:Category:Inflammation|inflammation]] and other immune responses
+* The expression of '''[[Cytokines|cytokines]]''', which brings about [[Inflammation - Introduction|inflammation]] and other immune responses
 <br />
@@ Line 66: / Line 66: @@
 |}
 <br><br>
 {{Jim Bee 2007}}
 [[Category:Innate Immune System]]