Selenium - Nutrition - Revision history

Bara: /* References */

2016-05-11T08:53:22Z

References

Bara at 14:38, 1 June 2015

2015-06-01T14:38:37Z

Bara: /* Recognised Syndromes Related to Selenium Deficiency */

2015-05-22T08:02:51Z

Recognised Syndromes Related to Selenium Deficiency

Bara: /* References */

2015-05-18T21:15:32Z

References

Bara: /* Toxicity */

2015-05-18T21:14:56Z

Toxicity

Bara: /* Roles in the Body */

2015-05-18T21:08:19Z

Roles in the Body

Bara: /* Why is it Important? */

2015-05-18T21:05:30Z

Why is it Important?

Bara: /* References */

2015-05-14T15:05:05Z

References

Ggaitskell at 18:47, 13 May 2015

2015-05-13T18:47:44Z

Bara: Text replace - "Category:To Do - Nutrition" to "Category:To Do - Nutrition Category:To Do - Nutrition GGP"

2015-05-06T19:17:03Z

Text replace - "Category:To Do - Nutrition" to "Category:To Do - Nutrition Category:To Do - Nutrition GGP"

← Older revision		Revision as of 08:53, 11 May 2016
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 ==References==
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 Researchers of selenium deficiency in dogs have reported clinical signs and changes in selenium status. Nevertheless, despite the role of selenium in the deiodinase enzymes, selenium deficiency did not appear to be linked to [[hypothyroidism]] in dogs<ref>Wedekind, KJ, Kirk, CA, Nachreiner, RF, Yu, S (2001). “Effect of varying selenium (Se) intake on thyroid hormone metabolism in dogs”. FASEB J. 15:A953.</ref>.
 ====Recognised Syndromes Related to Selenium Deficiency====
-#'''Selenium depletion''': Puppies fed a diet deficient in vitamin E and selenium, (selenium content 0.01 mg/kg on a dry matter (DM) basis) developed various clinical signs including anorexia, depression, abnormal breathing and coma within 6-8 weeks. Post mortem examination revealed muscular degeneration and renal mineralisation. Even when puppies were supplemented with selenium (dietary content of 0.5 mg/kg DM), mild skeletal myopathy was observed<ref>. Van Vleet, J, (1975). “Experimentally induced vitamin E-selenium deficiency in the growing dog”. J. Am. Vet. Med. Assoc. 166:769-774.</ref>.
+#'''Selenium depletion''': Puppies fed a diet deficient in vitamin E and selenium, (selenium content 0.01 mg/kg on a [[Nutrition Glossary#Dry Matter Basis|dry matter (DM) basis]]) developed various clinical signs including anorexia, depression, abnormal breathing and coma within 6-8 weeks. Post mortem examination revealed muscular degeneration and renal mineralisation. Even when puppies were supplemented with selenium (dietary content of 0.5 mg/kg DM), mild skeletal myopathy was observed<ref>. Van Vleet, J, (1975). “Experimentally induced vitamin E-selenium deficiency in the growing dog”. J. Am. Vet. Med. Assoc. 166:769-774.</ref>.
 #'''Serum selenium''': Purified diets containing a selenium content of less than 0.21 mg/kg DM were insufficient to support normal serum selenium concentrations in 9-week-old beagle puppies<ref name="Wedekind">Wedekind, KJ, Combs Jr, GF (2000). “Selenium in petfoods: Is bioavailability an issue?”.  Compend. Contin. Educ. Pract. Vet. 22(suppl.):17-22.</ref>.

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 ==Toxicity==
 ===Dog:===
-Selenium is probably the only nutrient that was studied for its toxic effects many years before its essentiality was discovered. A study in 1943<ref>Rhian, M, Moxon, AA (1943). “Chronic selenium poisoning in dogs and its prevention by arsenic”. J. Pharm. Exp. Therap. 78:249-264.</ref> showed that dietary selenium contents of 10 mg/kg DM as sodium selenite or 7.2 mg/kg DM as organic selenium were toxic to dogs as indicated by impaired growth and low food intake. More recent investigations showed that when dogs were fed a dietary selenium content of 5 mg/kg DM for 24 weeks resulted in both a reduction in food intake and impaired hair growth<ref>Wedekind, KJ, Kirk, CA, Yu, S, Nachreiner, RF (2002). “Defining the safe lower and upper limits for selenium (Se) in adult dogs”. Fed. Proc. 16:A992-A993.</ref><ref>Yu, S, Wedekind, KJ, Kirk, CA, Nachreiner, RF (2006). “Primary hair growth in dogs depends on dietary selenium concentrations”. J. Anim. Physiol. Anim. Nutr. 90:146-151.</ref>.
+Selenium is probably the only nutrient that was studied for its toxic effects many years before its [[Nutrition Glossary#Essential Nutrients|essentiality]] was discovered. A study in 1943<ref>Rhian, M, Moxon, AA (1943). “Chronic selenium poisoning in dogs and its prevention by arsenic”. J. Pharm. Exp. Therap. 78:249-264.</ref> showed that dietary selenium contents of 10 mg/kg DM as sodium selenite or 7.2 mg/kg DM as organic selenium were toxic to dogs as indicated by impaired growth and low food intake. More recent investigations showed that when dogs were fed a dietary selenium content of 5 mg/kg DM for 24 weeks resulted in both a reduction in food intake and impaired [[Hair - Anatomy & Physiology|hair]] growth<ref>Wedekind, KJ, Kirk, CA, Yu, S, Nachreiner, RF (2002). “Defining the safe lower and upper limits for selenium (Se) in adult dogs”. Fed. Proc. 16:A992-A993.</ref><ref>Yu, S, Wedekind, KJ, Kirk, CA, Nachreiner, RF (2006). “Primary hair growth in dogs depends on dietary selenium concentrations”. J. Anim. Physiol. Anim. Nutr. 90:146-151.</ref>.
 ===Cat:===
-Cats seem to be more resistant than dogs to the toxic effects of selenium. Adult cats were fed up to 10 mg selenium/kg diet DM in an organic form (selenomethionine) for 26 weeks with no signs of toxicity<ref>Wedekind, KJ, Kirk, CA, Yu, S, Nachreiner, RF (2003). “Defining the safe lower and upper limits for selenium in adult cats”. J. Anim. Sci. 81(suppl.):90 (abstr.).</ref>. The difference in selenium tolerance between the two species can be explained by the fact that cats are more efficient at excreting excess selenium in the urine and store less selenium in the liver<ref name="Todd">Todd, SE, Thomas, DG, Bosch, G, Hendriks, WH (2012). “Selenium status in adult cats and dogs fed high levels of dietary inorganic and organic selenium”. J. Anim. Sci. 90:2549-2555.</ref>.
+Cats seem to be more resistant than dogs to the toxic effects of selenium. Adult cats were fed up to 10 mg selenium/kg diet DM in an organic form (selenomethionine) for 26 weeks with no signs of toxicity<ref>Wedekind, KJ, Kirk, CA, Yu, S, Nachreiner, RF (2003). “Defining the safe lower and upper limits for selenium in adult cats”. J. Anim. Sci. 81(suppl.):90 (abstr.).</ref>. The difference in selenium tolerance between the two species can be explained by the fact that cats are more efficient at excreting excess selenium in the urine and store less selenium in the [[Liver - Anatomy & Physiology|liver]]<ref name="Todd">Todd, SE, Thomas, DG, Bosch, G, Hendriks, WH (2012). “Selenium status in adult cats and dogs fed high levels of dietary inorganic and organic selenium”. J. Anim. Sci. 90:2549-2555.</ref>.
 ===Dietary Sources===
-Selenium is found in a wide variety of plant and animal sources but usually at low concentrations. Meats, fish and bread are reported to supply good amounts of bioavailable selenium. Some studies suggest that plant sources are more bioavailable than animal sources. In commercial pet foods selenium bioavailabilities of 30% and 53% for canned and dry products, respectively have been reported<ref>Wedekind, KJ, Beyer, R, Combs Jr, GF (1998). “Is selenium addition necessary in petfoods?”. FASEB J. 12:A823.</ref>. To ensure nutritional adequacy pet foods can be supplemented with inorganic selenium compounds such as sodium selenate or selenite or an organic source like selenomethionine. The bioavailabilities of these selenium compounds appear to be similar: a study comparing high intakes of selenium in cats and dogs fed selenium in either inorganic or organic forms found no major differences in results for the two sources<ref name="Todd"/>.
+Selenium is found in a wide variety of plant and animal sources but usually at low concentrations. Meats, fish and bread are reported to supply good amounts of [[Nutrition Glossary#Bioavailability|bioavailable]] selenium. Some studies suggest that plant sources are more bioavailable than animal sources. In commercial pet foods, selenium bioavailabilities of 30% and 53% for canned and dry products, respectively have been reported<ref>Wedekind, KJ, Beyer, R, Combs Jr, GF (1998). “Is selenium addition necessary in petfoods?”. FASEB J. 12:A823.</ref>. To ensure nutritional adequacy pet foods can be supplemented with inorganic selenium compounds such as sodium selenate or selenite or an organic source like selenomethionine. The bioavailabilities of these selenium compounds appear to be similar: a study comparing high intakes of selenium in cats and dogs fed selenium in either inorganic or organic forms found no major differences in results for the two sources<ref name="Todd"/>.
 ==References==

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 ==Roles in the Body==
-There is little direct information on the metabolism of selenium in dogs and cats but studies in other mammals, including man, show that after absorption selenium is taken up by [[Erythrocytes|red blood cells]] then released into the plasma where it is bound to [[albumin]] and transported to the tissues. In all the selenium-containing enzymes selenium exists as selenocysteine, which can be formed from selenomethionine by the same metabolic pathways that convert [[Methionine and Cysteine - Nutrition|methionine to cysteine]]. Selenium is a component of deiodinase enzymes responsible for the conversion of thyroxine to tri-iodothyronine, the active form of [[Iodine - Nutrition|thyroid hormone]]. Selenium-containing proteins have been reported to support the immune response and '''protect against certain cancers'''. There is also some evidence that selenium may be protective against the adverse effects of mercury in cats, perhaps by inhibiting its absorption<ref>Houpt, K, Essick, L, Shaw, E, Alo, D, Gilmartin, J, Gutenmann, W, Littman, C, Lisk, D (1988). “A tuna fish diet influences cat behaviour”. J. Toxicol. Environ. Health 24:161-172.</ref>. Urine is the primary excretion route for selenium and the major urinary metabolite is selenosugar B, a compound of selenium and galactosamine<ref>Suzuki, K (2005). “Metabolomics of selenium: Se metabolites based on speciation studies”. J. Health Sci. 51:107-114.</ref>.
+There is little direct information on the metabolism of selenium in dogs and cats but studies in other mammals, including man, show that after absorption selenium is taken up by [[Erythrocytes|red blood cells]] then released into the plasma where it is bound to [[albumin]] and transported to the tissues. In all the selenium-containing enzymes selenium exists as selenocysteine, which can be formed from selenomethionine by the same metabolic pathways that convert [[Methionine and Cysteine - Nutrition|methionine to cysteine]]. Selenium is a component of deiodinase enzymes responsible for the conversion of thyroxine to tri-iodothyronine, the active form of [[Thyroid Gland - Anatomy & Physiology#Thyroid Hormone Physiology|thyroid hormone]]. Selenium-containing proteins have been reported to support the immune response and '''protect against certain cancers'''. There is also some evidence that selenium may be protective against the adverse effects of mercury in cats, perhaps by inhibiting its absorption<ref>Houpt, K, Essick, L, Shaw, E, Alo, D, Gilmartin, J, Gutenmann, W, Littman, C, Lisk, D (1988). “A tuna fish diet influences cat behaviour”. J. Toxicol. Environ. Health 24:161-172.</ref>. Urine is the primary excretion route for selenium and the major urinary metabolite is selenosugar B, a compound of selenium and galactosamine<ref>Suzuki, K (2005). “Metabolomics of selenium: Se metabolites based on speciation studies”. J. Health Sci. 51:107-114.</ref>.
 ==Consequences of Selenium Deficiency==

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 ==Why is it Important?==
-The nutritional essentiality of selenium was first demonstrated when it was found to be an '''integral part of the enzyme glutathione peroxidase, which protects the body against oxidative damage such as that caused by free radicals'''. In this respect selenium is closely linked with [[Vitamin E (α-Tocopherol) - Nutrition|vitamin E]] and one nutrient can to some extent “spare” a deficiency of the other. Nevertheless, selenium has its own unique function and is a component of other enzymes and proteins.
+The nutritional essentiality of selenium was first demonstrated when it was found to be an '''integral part of the enzyme glutathione peroxidase, which protects the body against oxidative damage such as that caused by free radicals'''. In this respect, selenium is closely linked with [[Vitamin E (α-Tocopherol) - Nutrition|vitamin E]] and one nutrient can to some extent “spare” a deficiency of the other. Nevertheless, selenium has its own unique function and is a component of other enzymes and [[Protein - Nutrition|proteins]].
 ==Roles in the Body==

← Older revision		Revision as of 19:17, 6 May 2015
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	[[Category:To Do - Nutrition]]		[[Category:To Do - Nutrition]]
		+	[[Category:To Do - Nutrition GGP]]