Sevoflurane - Revision history

Shannanigans969: /* Pharmacokinetics */

2012-09-18T09:17:56Z

Pharmacokinetics

Bara at 17:17, 24 May 2011

2011-05-24T17:17:51Z

Bara at 16:47, 25 January 2011

2011-01-25T16:47:00Z

Karag7: /* Pharmacokinetics */

2009-09-01T16:44:42Z

Pharmacokinetics

A.allison at 15:03, 1 September 2009

2009-09-01T15:03:44Z

Hstenning: New page: {{unfinished}} '''Sevoflurane''' is very similar to isoflurane but is less potent. However, it's odour is less pungent making it more suitable for mask induction, but can a...

2009-04-16T15:14:06Z

New page: {{unfinished}} '''Sevoflurane''' is very similar to isoflurane but is less potent. However, it's odour is less pungent making it more suitable for mask induction, but can a...

New page

{{unfinished}}

'''Sevoflurane''' is very similar to [[Isoflurane|isoflurane]] but is less potent. However, it's odour is less pungent making it more suitable for mask induction, but can also be used as a maintentance agent. It is becoming more popular in veterinary anaesthesia.

==Pharmacokinetics==
Sevoflurane is also a halogenated ether. It is also stable and nonflammable. Alkaline carbon dioxide absorbents react with sevoflurane to produced a potentially toxic compound. This can be influenced by environmental temperature, sevoflurane concentrations, use of baralyme rather then sodalime, low flow rates and already exposed absorbents. The '''blood:gas partition coefficient''' is very low, meaning that has a rapid onset of action. It has a high tissue solubility however, which means that recovery is more prolonged compared to [[Isoflurane|isoflurane]] or [[Halothane|halothane]]. The '''MAC''' of sevoflurane is approximately ''2.3%'' and is therefore less potent the other agents. Sevoflurane undergoes a small amount of hepatic metabolism.

==Adverse Effects==
===Central Nervous System===
*Increases intracranial pressure due to cerebral vasodilation.

===Cardiovascular System===
*Mild myocardial contractility depression.
*Decreased arterial blood pressure and systemic vascular resistance.

===Other Systems===
*There is an increase in hepatic artery flow, but reduced in the hepatic portal vein, like isoflurane.

==Contraindications==
*It is advisable to avoid the use of sevoflurane in patients with renal disease as there is a potential for further renal damage.

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 ==Pharmacokinetics==
-Sevoflurane is also a halogenated ether. It is also stable and nonflammable. Alkaline carbon dioxide absorbents react with sevoflurane to produced a potentially toxic compound. This can be influenced by environmental temperature, sevoflurane concentrations, use of baralyme rather then sodalime, low flow rates and already exposed absorbents. The '''blood:gas partition coefficient''' is very low, meaning that has a rapid onset of action. It has a high tissue solubility however, which means that recovery is more prolonged compared to [[Isoflurane|isoflurane]] or [[Halothane|halothane]]. The '''MAC''' of sevoflurane is approximately ''2.4%'' in dogs and ''2.6%'' in cats and is therefore less potent the other agents. Sevoflurane undergoes a small amount of hepatic metabolism.
+Sevoflurane is also a halogenated ether. It is also stable and nonflammable. Alkaline carbon dioxide absorbents react with sevoflurane to produced a potentially toxic compound. This can be influenced by environmental temperature, sevoflurane concentrations, use of baralyme rather then sodalime, low flow rates and already exposed absorbents. The '''blood:gas partition coefficient''' is very low, meaning that has a rapid onset of action. It has a high tissue solubility however, which means that recovery is more prolonged compared to [[Isoflurane|isoflurane]] or [[Halothane|halothane]]. The '''MAC''' of sevoflurane is approximately ''2.4%'' in dogs and ''2.6%'' in cats and is therefore less potent than other agents. Sevoflurane undergoes a small amount of hepatic metabolism.
 ==Adverse Effects==

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 ==Introduction==
 '''Sevoflurane''' is very similar to [[Isoflurane|isoflurane]] but is less potent. However, it's odour is less pungent making it more suitable for mask induction, but can also be used as a maintentance agent. It is becoming more popular in veterinary anaesthesia.
@@ Line 21: / Line 20: @@
 [[Category:Inhalation Anaesthetic Agents]]

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 {{unfinished}}
-{{toplink
+==Introduction==
 '''Sevoflurane''' is very similar to [[Isoflurane|isoflurane]] but is less potent. However, it's odour is less pungent making it more suitable for mask induction, but can also be used as a maintentance agent. It is becoming more popular in veterinary anaesthesia.
@@ Line 29: / Line 19: @@
 ==Contraindications==
 *It is advisable to avoid the use of sevoflurane in patients with renal disease as there is a potential for further renal damage.