Spindle Cell Tumours - Revision history

Fiorecastro at 16:04, 6 January 2023

2023-01-06T16:04:08Z

Bara at 18:31, 18 July 2012

2012-07-18T18:31:16Z

Bara: /* Treatment and Prognosis */

2011-09-03T17:51:31Z

Treatment and Prognosis

HelenD at 08:22, 19 August 2011

2011-08-19T08:22:47Z

Bara: /* Treatment and Prognosis */

2011-08-15T17:12:42Z

Treatment and Prognosis

Bara: /* Treatment and Prognosis */

2011-08-15T17:09:26Z

Treatment and Prognosis

Bara at 14:29, 15 August 2011

2011-08-15T14:29:46Z

HelenD: /* Treatment and prognosis */

2011-08-09T06:41:10Z

Treatment and prognosis

HelenD: /* Treatment and prognosis */

2011-08-08T16:34:10Z

Treatment and prognosis

HelenD: Created page with "==Introduction== Spindle cells are of '''mesenchymal origin''', and form the body's connective tissue, fat, muscle, bone, cartilage and blood vessels. Spindle cell tumours can ..."

2011-08-08T09:24:19Z

Created page with "==Introduction== Spindle cells are of '''mesenchymal origin''', and form the body's connective tissue, fat, muscle, bone, cartilage and blood vessels. Spindle cell tumours can ..."

New page

==Introduction==
Spindle cells are of '''mesenchymal origin''', and form the body's connective tissue, fat, muscle, bone, cartilage and blood vessels.

Spindle cell tumours can be benign or malignant, and will arise from these different cell lines.

It can be '''difficult to differentiate''' between the different forms of spindle cell tumours, and also to distinguish between spindle cell neoplasia and a fibroplastic spindle cell proliferative response.

===Connective tissue tumours===
[[Fibroma]] and [[Fibrosarcoma]]

Myxoma and myxosarcoma

===Tumours of fat===
[[Lipoma]] and liposarcoma

===Tumours of muscle===
[[Leiomyoma]] and leiomyosarcoma

===Tumours of the blood vessel endothelium===
[[Haemangioma]] and [[Haemangiosarcoma]]

===Tumours of the lymphatics===
Lymphangioma and lymphangiosarcoma

===Other tumours===
[[Haemangiopericytoma]] and [[Peripheral Nerve Tumours|Schwannoma]]

==Diagnosis==
Generally spindle cell tumours '''do not exfoliate well''', although exception exist.

On '''cytological examination''': cells are individual rather than adherent, fusiform, and with indistinct cell borders. Nuclei are often fusiform as well and cytoplasmic tails may fade into the background. It may be possible to determine the tissue of origin if there is evidence of collagen, cartilage, bone, fat or myxomatous material formation by the tumour cells.

Often, a diagnosis of spindle cell tumour is as specific a diagnosis as can be made.

Common cytological findings for '''benign''' spindle cell tumours include: small spindle-shaped cells, small nuclei, minimal anisocytosis.

Cyological findings for '''soft tissue sarcomas''' include:
:large, plump spindle cells
:large nuclei and prominent nucleoli
:prominent nuclear variability
:multinucleated giant cells
:pink extracellular stroma

Spindle cell proliferation occurs as a '''fibroplastic response''' in granulomatous inflammation, and this may be impossible to differentiate from benign or malignant neoplasms.

A '''biopsy and histopathology''' are usually necessary to confirm the diagnosis.

==Treatment and prognosis==
'''Benign forms''' are usually well circumscribed and can be surgically removed with an '''excellent prognosis'''.

'''Malignant forms''' are often '''highly infiltrative and locally aggressive''', with a high likelihood of '''recurrence'''. '''Wide surgical excision''' is the treatment of choice.

They metastasise rarely (apart from [[Haemangiosarcoma|haemangiosarcomas]]).

In all cases, a '''rapid and accurate diagnosis''' is important for treatment and prognosis.

==References==
Bond, R. (2009) '''Skin Neoplasia''' ''RVC student notes''

Jackson, M. (2007) '''Veterinary clinical pathology''' ''Wiley-Blackwell''

Freeman, K. (2007) '''Self-assessment colour review of Veterinary Cytology''' ''Manson Publishing''

[[Category:To Do - Helen]]
[[Category:To Do - Review]]

@@ Line 1: / Line 1: @@
-{{OpenPagesTop}}
 ==Introduction==
 Spindle cells are of '''mesenchymal origin''', and form the body's connective tissue, fat, muscle, bone, cartilage and blood vessels.
@@ Line 71: / Line 71: @@
 {{review}}
-{{OpenPages}}
+==Webinars==
 [[Category:Neoplasia]]
 [[Category:Expert Review]]

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 ==Introduction==
 Spindle cells are of '''mesenchymal origin''', and form the body's connective tissue, fat, muscle, bone, cartilage and blood vessels.
@@ Line 69: / Line 70: @@
 {{review}}
 [[Category:Neoplasia]]
 [[Category:Expert Review]]

@@ Line 57: / Line 57: @@
 {{Learning
-|flashcards = [[Cytology Q&A 17]]
+|flashcards = [[Cytology Q&A 04]]<br>[[Cytology Q&A 17]]
 }}

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 {{Learning
-|flashcards = [[Cytology Q&A 04]]<br>[[Cytology Q&A 17]]
+|flashcards = [[Cytology Q&A 17]]
 }}

@@ Line 55: / Line 55: @@
 {{Learning
-|flashcards = [[Cytology Q&A 04]]
+|flashcards = [[Cytology Q&A 04]]<br>[[Cytology Q&A 17]]
 }}

@@ Line 2: / Line 2: @@
 Spindle cells are of '''mesenchymal origin''', and form the body's connective tissue, fat, muscle, bone, cartilage and blood vessels.
-Spindle cell tumours can be benign or malignant, and will arise from these different cell lines.
+The name 'spindle cell' refers to the shape  of the cell on cytology and histology.
 It can be '''difficult to differentiate''' between the different forms of spindle cell tumours, and also to distinguish between spindle cell neoplasia and a fibroplastic spindle cell proliferative response.
@@ Line 34: / Line 36: @@
 Common cytological findings for '''benign''' spindle cell tumours include: small spindle-shaped cells, small nuclei, minimal anisocytosis.
-Cyological findings for '''soft tissue sarcomas''' include:
+Cyological findings for '''sarcomas''' include:
 :large, plump spindle cells
 :large nuclei and prominent nucleoli
@@ Line 48: / Line 50: @@
 '''Benign forms''' are usually well circumscribed and can be surgically removed with an '''excellent prognosis'''.
-'''Malignant forms''' are often '''highly infiltrative and locally aggressive''', with a high likelihood of '''recurrence'''. '''Wide surgical excision''' is the treatment of choice.
+'''Sarcomas''' are often '''highly infiltrative and locally aggressive''', with a high likelihood of '''recurrence'''. '''Wide surgical excision''' is the treatment of choice.
 They metastasise rarely (apart from [[Haemangiosarcoma|haemangiosarcomas]]).

@@ Line 6: / Line 6: @@
 It can be '''difficult to differentiate''' between the different forms of spindle cell tumours, and also to distinguish between spindle cell neoplasia and a fibroplastic spindle cell proliferative response.
-===Connective tissue tumours===
+'''Connective tissue tumours'''
-[[Fibroma]] and [[Fibrosarcoma]]
+:[[Fibroma]] and [[Fibrosarcoma]]
-Myxoma and myxosarcoma
+'''Tumours of fat'''
-===Tumours of fat===
+'''Tumours of muscle'''
-[[Lipoma]] and liposarcoma
+:[[Leiomyoma]] and leiomyosarcoma
-===Tumours of muscle===
+'''Tumours of the blood vessel endothelium'''
-[[Leiomyoma]] and leiomyosarcoma
+:[[Haemangioma]] and [[Haemangiosarcoma]]
-===Tumours of the blood vessel endothelium===
+'''Tumours of the lymphatics'''
-[[Haemangioma]] and [[Haemangiosarcoma]]
+:Lymphangioma and lymphangiosarcoma
-===Tumours of the lymphatics===
+'''Other tumours'''
-Lymphangioma and lymphangiosarcoma
+:[[Haemangiopericytoma]] and [[Peripheral Nerve Tumours|Schwannoma]]
 ==Diagnosis==
-Generally spindle cell tumours '''do not exfoliate well''', although exception exist.
+Generally spindle cell tumours '''do not exfoliate well''', although exceptions exist.
 On '''cytological examination''': cells are individual rather than adherent, fusiform, and with indistinct cell borders. Nuclei are often fusiform as well and cytoplasmic tails may fade into the background. It may be possible to determine the tissue of origin if there is evidence of collagen, cartilage, bone, fat or myxomatous material formation by the tumour cells.
@@ Line 46: / Line 45: @@
 A '''biopsy and histopathology''' are usually necessary to confirm the diagnosis.
-==Treatment and prognosis==
+==Treatment and Prognosis==
 '''Benign forms''' are usually well circumscribed and can be surgically removed with an '''excellent prognosis'''.
@@ Line 66: / Line 65: @@
 Freeman, K. (2007) '''Self-assessment colour review of Veterinary Cytology''' ''Manson Publishing''
-[[Category:To Do - Helen]]
-[[Category:To Do - Review]]
+{{review}}

← Older revision		Revision as of 16:34, 8 August 2011
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	In all cases, a '''rapid and accurate diagnosis''' is important for treatment and prognosis.		In all cases, a '''rapid and accurate diagnosis''' is important for treatment and prognosis.
		+
		+	{{Learning
		+	\|flashcards = [[Cytology Q&A 4]]
		+	}}

	==References==		==References==