Uterine Adenocarcinoma - Rabbit - Revision history

Bara at 18:35, 26 July 2012

2012-07-26T18:35:14Z

Bara at 23:04, 24 September 2011

2011-09-24T23:04:51Z

HelenD: Created page with "==Introduction== This is the '''most common neoplasm in rabbits''', with an incidence of up to '''60% in intact females over 3 years old'''. The tumour arises from the '''endom..."

2011-08-11T11:08:02Z

Created page with "==Introduction== This is the '''most common neoplasm in rabbits''', with an incidence of up to '''60% in intact females over 3 years old'''. The tumour arises from the '''endom..."

New page

==Introduction==
This is the '''most common neoplasm in rabbits''', with an incidence of up to '''60% in intact females over 3 years old'''.

The tumour arises from the '''endometrial glandular epithelium'''. It may be preceeded by endometriosis, endometritis, endometrial hyperplasia or endometrial venous aneurysms. These tumours frequently '''bleed''' and the haemorrhage can be life-threatening.

The tumours '''metastasise''' locally by extension into the myometrium and peritoneum, but also to distant locations such as the lungs, brain, bone and liver.

Tumours are usually present in '''both uterine horns''' and may occur simultaneously with pyometra or pregnancy.

'''Mammary neoplasia or cystic mastitis''' are often found in does with uterine adenocarcinoma.

The disease occurs in intact females over the age of 3-4. All breeds are at risk but the highest incidence is reported in French Silver, Havana and '''Dutch breed''' does.

==Clinical Signs==
Does are usually presented for '''haematuria''' by the owner. It isn't true haematuria, but blood is released from the uterus during micturition. Blood clots are sometimes seen.

There may also be a '''serosanguinous vaginal discharge'''.

'''Cystic mastitis or neoplasia''' may involve one of more mammary glands.

If does are presented late in the disease with metastasis, they may show signs of '''lethary, dyspnoea and pale mucous membranes'''.

The tumour may not be '''palpable''' until late in the disease process, but may feel as firm midcaudal masses palpable between the bladder and colon.

==Diagnosis==
'''Haematology and biochemistry''' will determine the overall health status of the animal, and may reveal a variably regenerative anaemia. There may be increased liver enzymes with metastasis.

'''Abdominal radiography''' may reveal an abdominal mass, dorsal to the bladder

'''Thoracic radiography''' may reveal evidence of metastases.

'''Ultrasonography''' is very useful in outlining the location and architecture of the uterine mass.

An ultrasound-guided '''cystocentesis''' can be performed to differentiate between haematuria and uterine bleeding.

Mammary masses can be examined with '''cytology'''.

'''Histopathology''' is required for a definitive diagnosis, and will reveal a well-differentiated adenocarcinoma

'''Gross inspection of the uterus''' shows: cauliflower-like or papillary projections into the uterine lumen. The tumours may be multicentric involving both horns, and may have a haemorrhagic or necrotic centre.

==Differential Diagnoses==
Endometrial venous aneurisms

Pregnancy

Endometrial hyperplasia, hydrometra or mucometra

Pyometra

Other uterine tumours

Other mid-caudal abdominal masses

==Treatment==
'''Ovariohysterectomy''' is the treatment of choice, and is curative if metastasis has not occurred.

Even if metastasis is not grossly visible at the time of surgery, checks should be performed at '''6-monthly intervals''' and a the prognosis is still guarded.

'''Good nursing care''' is paramount in ensuring rabbits do not develop ileus and other gastro-intestinal problems post-operatively.

A '''blood transfusion''' may be necessary if the rabbit is severely anaemic or there is significant haemorrhage during surgery.

Neoplastic mammary glands should also be '''excised'''.

If metastasis is evident on radiographs, the '''prognosis is grave''' and euthanasia is the best option.

==Prevention==
'''Ovariohysterectomy''' is recommended for all non-breeding rabbits, usually between 6 months and 2 years of age.

If rabbits are used for breeding, this should be stopped at 4 years and rabbits spayed, as this is when most tumours occur.

{{Learning
|flashcards = [[Rabbit Medicine and Surgery Q&A 21]]
}}

==References==
Rosenthal, K. (2008) '''Rapid review of exotic animal medicine and husbandry''' ''Manson Publishing''

Oglesbee, B. (2006) '''The 5-minute veterinary consult: ferret and rabbit''' ''Wiley-Blackwell''

Merck and co (2008) '''The Merck Veterinary Manual''' ''Merial''

[[Category:To Do - Helen]]
[[Category:To Do - Review]]

@@ Line 1: / Line 1: @@
 ==Introduction==
 This is the '''most common neoplasm in rabbits''', with an incidence of up to '''60% in intact females over 3 years old'''.
@@ Line 79: / Line 80: @@
 {{review}}
 [[Category:Neoplasia]]
 [[Category:Rabbit Urogenital Disorders]]
 [[Category:Expert Review - Exotics]]

@@ Line 2: / Line 2: @@
 This is the '''most common neoplasm in rabbits''', with an incidence of up to '''60% in intact females over 3 years old'''.
-The tumour arises from the '''endometrial glandular epithelium'''. It may be preceeded by endometriosis, endometritis, endometrial hyperplasia or endometrial venous aneurysms. These tumours frequently '''bleed''' and the haemorrhage can be life-threatening.
+The tumour arises from the '''endometrial glandular epithelium'''. It may be preceded by endometriosis, endometritis, endometrial hyperplasia or endometrial venous aneurysms. These tumours frequently '''bleed''' and the haemorrhage can be life-threatening.
 The tumours '''metastasise''' locally by extension into the myometrium and peritoneum, but also to distant locations such as the lungs, brain, bone and liver.
@@ Line 13: / Line 13: @@
 ==Clinical Signs==
-Does are usually presented for '''haematuria''' by the owner. It isn't true haematuria, but blood is released from the uterus during micturition. Blood clots are sometimes seen.
+Does are usually presented for '''[[haematuria]]''' by the owner. It isn't true haematuria, but blood is released from the uterus during micturition. Blood clots are sometimes seen.
 There may also be a '''serosanguinous vaginal discharge'''.
@@ Line 19: / Line 19: @@
 '''Cystic mastitis or neoplasia''' may involve one of more mammary glands.
-If does are presented late in the disease with metastasis, they may show signs of '''lethary, dyspnoea and pale mucous membranes'''.
+If does are presented late in the disease with metastasis, they may show signs of '''lethargy, dyspnoea and pale mucous membranes'''.
-The tumour may not be '''palpable''' until late in the disease process, but may feel as firm midcaudal masses palpable between the bladder and colon.
+The tumour may not be '''palpable''' until late in the disease process, but may feel as firm midcaudal masses between the bladder and colon.
 ==Diagnosis==
-'''Haematology and biochemistry''' will determine the overall health status of the animal, and may reveal a variably regenerative anaemia. There may be increased liver enzymes with metastasis.
+'''Haematology and biochemistry''' will determine the overall health status of the animal, and may reveal a variably regenerative [[anaemia]]. There may be increased liver enzymes with metastasis.
-'''Abdominal radiography''' may reveal an abdominal mass, dorsal to the bladder
+'''Abdominal radiography''' may reveal an abdominal mass, dorsal to the bladder.
 '''Thoracic radiography''' may reveal evidence of metastases.
@@ Line 36: / Line 36: @@
 Mammary masses can be examined with '''cytology'''.
-'''Histopathology''' is required for a definitive diagnosis, and will reveal a well-differentiated adenocarcinoma
+'''Histopathology''' is required for a definitive diagnosis, and will reveal a well-differentiated adenocarcinoma.
 '''Gross inspection of the uterus''' shows: cauliflower-like or papillary projections into the uterine lumen. The tumours may be multicentric involving both horns, and may have a haemorrhagic or necrotic centre.
 ==Differential Diagnoses==
-Endometrial venous aneurisms
+:Endometrial venous aneurisms
+:Pregnancy
-Pregnancy
+:Endometrial hyperplasia, hydrometra or mucometra
+:Pyometra
-Endometrial hyperplasia, hydrometra or mucometra
+:Other uterine tumours
+:Other mid-caudal abdominal masses
 ==Treatment==
 '''Ovariohysterectomy''' is the treatment of choice, and is curative if metastasis has not occurred.
-Even if metastasis is not grossly visible at the time of surgery, checks should be performed at '''6-monthly intervals''' and a the prognosis is still guarded.
+Even if metastasis is not grossly visible at the time of surgery, checks should be performed at '''6-monthly intervals''' and the prognosis is still guarded.
-'''Good nursing care''' is paramount in ensuring rabbits do not develop ileus and other gastro-intestinal problems post-operatively.
+'''Good nursing care''' is paramount in ensuring rabbits do not develop [[Non-Obstructive Ileus – Rabbit|ileus]] and other gastro-intestinal problems post-operatively.
 A '''blood transfusion''' may be necessary if the rabbit is severely anaemic or there is significant haemorrhage during surgery.
@@ Line 82: / Line 77: @@
 Merck and co (2008) '''The Merck Veterinary Manual''' ''Merial''
-[[Category:To Do - Helen]]
-[[Category:To Do - Review]]
+{{review}}