Vasculitis - Revision history

Bara at 17:48, 17 October 2013

2013-10-17T17:48:05Z

Bara at 14:00, 20 July 2012

2012-07-20T14:00:04Z

Bara at 22:03, 6 September 2011

2011-09-06T22:03:25Z

HelenD at 15:42, 1 September 2011

2011-09-01T15:42:56Z

Bara at 16:16, 22 December 2010

2010-12-22T16:16:42Z

Bara at 23:03, 16 December 2010

2010-12-16T23:03:07Z

Bara: Text replace - "Category:Cardiovascular Pathology - Dog" to "Category:Cardiovascular Diseases - Dog"

2010-12-16T15:37:30Z

Text replace - "Category:Cardiovascular Pathology - Dog" to "Category:Cardiovascular Diseases - Dog"

Bara at 16:15, 15 December 2010

2010-12-15T16:15:45Z

Bara: New page: ===Description=== Vasculitis is an inflammatory disease of the vessels. Causes of vessel inflammation are due to the following: neoplasia, infection, toxins, drug reactions, trauma, ...

2010-07-01T14:45:55Z

New page: ===Description=== *Vasculitis is an inflammatory disease of the vessels. *Causes of vessel inflammation are due to the following: neoplasia, infection, toxins, drug reactions, trauma, ...

New page

===Description===

*Vasculitis is an inflammatory disease of the vessels.

*Causes of vessel inflammation are due to the following: neoplasia, infection, toxins, drug reactions, trauma, drug reactions, hypersensativity reactions etc.

===Diagnosis===

====History & Clinical Signs====

-Heat

-Edema

-Pain

-Petechiation

-Thrombosis

-Hemolysis
[[Category:Arterial_Pathology]][[Category:Venous_Pathology]][[Category:To_Do_-_Cardiovascular]]

← Older revision		Revision as of 17:48, 17 October 2013
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	[[Category:Vascular Diseases - Dog]][[Category:Vascular Diseases - Cat]]		[[Category:Vascular Diseases - Dog]][[Category:Vascular Diseases - Cat]]
	[[Category:Arterial_Pathology]][[Category:Venous_Pathology]]		[[Category:Arterial_Pathology]][[Category:Venous_Pathology]]
		+	[[Category:Cardiology Section]]

@@ Line 1: / Line 1: @@
 ==Introduction==
 Vasculitis is an '''inflammatory disease of blood vessels'''.
@@ Line 80: / Line 81: @@
 {{review}}
 [[Category:Expert Review]]
 [[Category:Vascular Diseases - Dog]][[Category:Vascular Diseases - Cat]]
 [[Category:Arterial_Pathology]][[Category:Venous_Pathology]]

@@ Line 2: / Line 2: @@
 Vasculitis is an '''inflammatory disease of blood vessels'''.
-It is characteristed histologically by the accumulation of leukocytes within and around the vessel wall. It can be of neutrophilic (leukoclastic/non-leukoclastic), lymphocytic, eosinophilic, granulomatous or mixed cell type.
+It is characterised histologically by the accumulation of leukocytes within and around the vessel wall. It can be of neutrophilic (leukoclastic/non-leukoclastic), lymphocytic, eosinophilic, granulomatous or mixed cell type.
-It is a combination of '''type III and type I''' hypersensitivity reactions.
+It is a combination of '''[[Type III Hypersensitivity|type III]] and [[Type I Hypersensitivity|type I]]''' [[:Category:Hypersensitivity|hypersensitivity]] reactions.
 Endothelial damage by an infectious agent, parasite infestation, eridotoxin or immune complex deposition initiates '''local inflammation, neutrophil accumulation and complement activation'''. Neutrophils release lysosomal enzymes leading to necrosis of the vessel wall, thrombosis and haemorrhage.
@@ Line 37: / Line 37: @@
 '''Staphylococcal hypersensitivity'''
-'''Food hypersensitivity causing urticarial vasculitis'''
+'''Food hypersensitivity causing [[Urticaria|urticarial]] vasculitis'''
 '''[[FeLV]] and [[FIV]]-associated vasculitis''' in cats
 ==Clinical Signs==
-Clinical features of vasculitis are variable and depend on the vessels involved.
+Clinical features of vasculitis are variable and depend on the vessels involved. It can present as: purpura, haemorrhagic bullae, necrosis and punched-out ulcers. It often affects the '''extremities''' such as the '''ear tips, tail''', lips, paws and oral mucosa, and can be painful.
-It can present as: purpura, haemorrhagic bullae, necrosis and punched-out ulcers
+The systemic signs usually reflect the organ involved (hepatopathy, arthropathy, myopathy...). There may also be '''vague systemic signs of illness''': lethargy, lymphadenopathy, vague pain, pyrexia and weight loss.
-It often affects the '''extremities''' such as the '''ear tips, tail''', lips, paws and oral mucosa, and can be painful.
+Signs associated with '''immmune-mediated disease''' include: [[thrombocytopaenia]] and polyarthropathy.
-The systemic signs usually reflect the organ involved (hepatopathy, arthropathy, myopathy..)
+'''Breed-related''' vasculitis include: familial cutaneous vasculopathy of German Shepherd Dogs, neutrophilic leukoclastic vasculitis of Jack Russell Terriers, ear margin vasculitis/[[Ear Margin Dermatosis|seborrhea]] in Dachshunds.
 ==Differential Diagnoses==
-Ear margin seborrhea, chemical and thermal burns, hepatocutaneous syndrome, erythema multiforme, dermatomyositis and sepsis
+[[Ear Margin Dermatosis|Ear margin seborrhea]], chemical and thermal burns, hepatocutaneous syndrome, erythema multiforme, [[Canine Dermatomyositis|dermatomyositis]] and sepsis
 ==Diagnosis==
-'''Immunodiagnostics''' to consider include: ANA titre, Coombs test, and cold agglutinin test.
+'''Immunodiagnostics''' to consider include: ANA titre, [[Agglutination|Coombs test]], and cold agglutinin test.
 '''Haematology, biochemistry and urinalysis''' may reveal a systemic disease.
@@ Line 71: / Line 65: @@
 '''Antibiotics''' may be a first line of therapy if drug reaction is not suspected.
-'''Immune-modulatory drugs''' which may help control an immune-mediated disease with concurrent vasculitis include: prednisolone, sulfasalazine, chlorambucil.
+'''Immune-modulatory drugs''' which may help control an immune-mediated disease with concurrent vasculitis include: prednisolone, sulfasalazine, chlorambucil. These should always be used until remission and then doses decreased to the lowest possible dose for controlling clinical signs.
 Prognosis is often '''guarded''', and depends on the underlying cause.
@@ Line 86: / Line 78: @@
 Day, M. (2010) '''Veterinary Immunology''' ''Manson Publishing''
 [[Category:Vascular Diseases - Dog]][[Category:Vascular Diseases - Cat]]
-[[Category:Arterial_Pathology]][[Category:Venous_Pathology]][[Category:To_Do_-_Cardiovascular]]
+[[Category:Arterial_Pathology]][[Category:Venous_Pathology]]

@@ Line 1: / Line 1: @@
-===Description===
+==Introduction==
-*Vasculitis is an inflammatory disease of the vessels.
+It is characteristed histologically by the accumulation of leukocytes within and around the vessel wall. It can be of neutrophilic (leukoclastic/non-leukoclastic), lymphocytic, eosinophilic, granulomatous or mixed cell type.
-*Causes of vessel inflammation are due to the following: neoplasia, infection, toxins, drug reactions, trauma, drug reactions, hypersensativity reactions etc.
+It is a combination of '''type III and type I''' hypersensitivity reactions.
-===Diagnosis===
+'''Any animal can be affected''', and the clinical significance depends on the number, size and type of vessels affected, and the presence of thrombosis, ischaemia and infarction.
-====History & Clinical Signs====
+==Aetiology==
--Heat
+'''[[Systemic Lupus Erythematosus]]'''
--Edema
+'''Cold agglutinin disease'''
--Pain
+'''[[Frostbite]]'''
--Petechiation
+'''[[Disseminated Intravascular Coagulation]]'''
--Thrombosis
+'''Lymphoreticular neoplasia'''
--Hemolysis
+'''Drug reactions'''
 [[Category:Vascular Diseases - Dog]][[Category:Vascular Diseases - Cat]]
 [[Category:Arterial_Pathology]][[Category:Venous_Pathology]][[Category:To_Do_-_Cardiovascular]]

← Older revision		Revision as of 16:16, 22 December 2010
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−	[[Category:Vascular Diseases - Dog]]	+	[[Category:Vascular Diseases - Dog]][[Category:Vascular Diseases - Cat]]
	[[Category:Arterial_Pathology]][[Category:Venous_Pathology]][[Category:To_Do_-_Cardiovascular]]		[[Category:Arterial_Pathology]][[Category:Venous_Pathology]][[Category:To_Do_-_Cardiovascular]]

← Older revision		Revision as of 23:03, 16 December 2010
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−	[[Category:~~Cardiovascular~~ Diseases - Dog]]	+	[[Category:Vascular Diseases - Dog]]
	[[Category:Arterial_Pathology]][[Category:Venous_Pathology]][[Category:To_Do_-_Cardiovascular]]		[[Category:Arterial_Pathology]][[Category:Venous_Pathology]][[Category:To_Do_-_Cardiovascular]]

← Older revision		Revision as of 15:37, 16 December 2010
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−	[[Category:Cardiovascular ~~Pathology~~ - Dog]]	+	[[Category:Cardiovascular Diseases - Dog]]
	[[Category:Arterial_Pathology]][[Category:Venous_Pathology]][[Category:To_Do_-_Cardiovascular]]		[[Category:Arterial_Pathology]][[Category:Venous_Pathology]][[Category:To_Do_-_Cardiovascular]]

← Older revision		Revision as of 16:15, 15 December 2010
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	-Hemolysis		-Hemolysis
		+
		+
		+
		+	[[Category:Cardiovascular Pathology - Dog]]
	[[Category:Arterial_Pathology]][[Category:Venous_Pathology]][[Category:To_Do_-_Cardiovascular]]		[[Category:Arterial_Pathology]][[Category:Venous_Pathology]][[Category:To_Do_-_Cardiovascular]]