Veterinary Dentistry Q&A 07 - Revision history

Bara at 17:05, 13 October 2011

2011-10-13T17:05:50Z

Bara at 22:51, 12 October 2011

2011-10-12T22:51:22Z

Ggaitskell at 20:23, 29 September 2011

2011-09-29T20:23:05Z

HelenD: Created page with "500px

|q1=What endocrinopathy should be considered in a cat with insulin-resistant diabetes mellitus, hepatomegaly, and a..."

2011-08-19T10:42:38Z

Created page with "[[|centre|500px]] <br /> <br /> <FlashCard questions="2"> |q1=What endocrinopathy should be considered in a cat with insulin-resistant diabetes mellitus, hepatomegaly, and a..."

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|q1=What endocrinopathy should be considered in a cat with insulin-resistant diabetes mellitus, hepatomegaly, and a large head with a protruding mandible?
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Chronic hypersecretion of growth hormone (GH) results in acromegaly. Growth hormone excesses induce peripheral insulin resistance.

Other clinical features that may be present include cardiomegaly, congestive heart failure, nephromegaly, nephropathy (proteinuria, azotemia), renal failure, weight gain/loss, body enlargement, arthropathy, large tongue, and central nervous system signs.
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|q2=What would be the most likely cause, and how would the diagnosis be confirmed?
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A GH-secreting tumor of the pituitary gland is the most common cause of acromegaly in cats.

Hyperadrenocorticism and hyperthyroidism are other endocrinopathies that may be associated with insulin-resistant diabetes and they should be excluded in the diagnostic evaluation of an insulin-resistant diabetic cat.

Demonstrating significantly elevated circulating GH concentrations is diagnostic for acromegaly; however, there is limited availability of veterinary laboratories performing feline GH assays. Indirect evaluation of growth hormone concentration by measuring somatomedin C (insulin-like growth factor-1) may be beneficial.

A presumptive diagnosis of acromegaly is made when the thyroid and adrenal glands are normal and the cat has characteristic clinical signs and laboratory data, and a pituitary mass is identified.

Computed tomography (CT) or magnetic resonance imaging (MRI) may be used to demonstrate a pituitary mass.
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 Other clinical features that may be present include cardiomegaly, congestive heart failure, nephromegaly, nephropathy (proteinuria, azotemia), renal failure, weight gain/loss, body enlargement, arthropathy, large tongue, and central nervous system signs.
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 Computed tomography (CT) or magnetic resonance imaging (MRI) may be used to demonstrate a pituitary mass.
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Veterinary Dentistry Q&A 07 - Revision history

Bara at 17:05, 13 October 2011

Bara at 22:51, 12 October 2011

Ggaitskell at 20:23, 29 September 2011

HelenD: Created page with "500px |q1=What endocrinopathy should be considered in a cat with insulin-resistant diabetes mellitus, hepatomegaly, and a..."

HelenD: Created page with "500px

|q1=What endocrinopathy should be considered in a cat with insulin-resistant diabetes mellitus, hepatomegaly, and a..."