Difference between revisions of "Glycogen Infiltration"
Jump to navigation
Jump to search
(Created page with "* Glycogen is normally present in substantial amounts in the liver and muscle. ** Is a readily utilisable source of energy. * Moderate glycogen i...") |
Fiorecastro (talk | contribs) |
||
Line 27: | Line 27: | ||
*** Stains the intracellular glycogen red. | *** Stains the intracellular glycogen red. | ||
+ | ==Webinars== | ||
+ | <rss max="10" highlight="none">https://www.thewebinarvet.com/endocrinology/webinars/feed</rss> | ||
[[Category:Degenerations and Infiltrations]] | [[Category:Degenerations and Infiltrations]] |
Latest revision as of 18:06, 7 December 2022
- Glycogen is normally present in substantial amounts in the liver and muscle.
- Is a readily utilisable source of energy.
- Moderate glycogen infiltration in the liver:
- Grossly - doesn't have much effect.
- Histologically - shows up as foamy cytoplasmic vacuoles, similar to that of fat.
- Some conditions may result in an increase in glycogen deposits.
- Diabetes mellitus
- Gives an increase in hepatic glycogen stores.
- May be overshadowed by the increased fat in the hepatocytes, and therefore difficult to see.
- Renal tubular deposits are more easily observed.
- Excessive glucocorticoids
- Could be due to:
- Hyperadrenocortism
- Animals being maintained on glucocorticoid therapy over a long period of time.
- Has more dramatic effect.
- Huge amounts of glycogen infiltration.
- Liver appears larger and paler.
- Vacuoles may be so extensive that the rest of the cytoplasm appear as pink strands passing from the nucleus to the plasma membrane.
- A "feathery appearance" or "web-like effect".
- Could be due to:
- Glycogen storage diseases
- Due to an inherited deficiency of an enzyme required for the breakdown of glycogen to glucose.
- Cells continuously accumulate glycogen.
- Seen in all tissues of the body but exerts its major effect in the CNS.
- Due to an inherited deficiency of an enzyme required for the breakdown of glycogen to glucose.
- Diabetes mellitus
- Selective staining must be employed to distinguish glycogen vacuoles from fatty vacuoles in the liver.
- Alcohol fixation is preferred.
- Best's Carmine is the commonly used stain.
- Stains the intracellular glycogen red.
Webinars
Failed to load RSS feed from https://www.thewebinarvet.com/endocrinology/webinars/feed: Error parsing XML for RSS