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===''Burkholderia pseudomallei===
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===''[[Burkholderia pseudomallei]]===
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*Causes [[Respiratory Bacterial Infections - Pathology#Melioidosis (Pseudoglanders)|melioidosis]] - endemic in Asia and Australia
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*Primarily infects rodents
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*Pathogenesis:
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**Infection via ingestion, inhalation or skin wounds from environment
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**Exotoxin, dermonecrotic protease and lecithinase implicated in pathogenicity
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**Strain virulence and host immunosuppression important
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*Clinical infections:
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**Opportunistic infection with stress and immunosuppression predisposing to disease
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**Abscesses develop in many organs including lungs, spleen, liver, joints, CNS, upper respiratory tract
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**Chronic, debilitating, progressive disease with long incubation period
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**Many animal species susceptible
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**Referred to as pseudoglanders in horses
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*Diagnosis:
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**Specimens: pus from abscesses, affected tissues, blood
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**Fluorescent antibody technique on tissue smears
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**Blood agar and MacConkey agar plates, incubated aerobically
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**Colonies have musty smell
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**Lactose fermentation on MacConkey
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**Slide agglutination
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**ELISA, complement fixation and indirect haemagglutination tests for serum antibodies
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*Treatment/control: slaughter of infected animals where exotic
      
[[Category:Bacteria]][[Category:Gram_negative_bacteria]][[Category:Rods]]
 
[[Category:Bacteria]][[Category:Gram_negative_bacteria]][[Category:Rods]]
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