Difference between revisions of "Visna-Maedi Virus"
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− | + | Maedi-Visna | |
− | + | ====Pathogenesis==== | |
+ | *Primary replication in '''lung macrophages''' | ||
+ | *These then carry infection to '''brain, lung, udder and/or joints''' | ||
+ | *T cells react: '''Type IV immune complex disease''' | ||
+ | *Target organs become chronically inflamed after 2-6 years | ||
+ | *Visna: | ||
+ | **Inflammation results in '''demyelination''' with '''subacute meningitis''' around ventricles and choroid plexus | ||
+ | **'''Posterior paresis''' progresses for up to a year until sheep can no longer stand | ||
+ | **For more on joint pathology, see [[Joints Inflammatory - Pathology#In Sheep|here]] | ||
+ | *Maedi: | ||
+ | **Alveolar septa become infiltrated by lymphocytes and macrophages | ||
+ | **Smooth muscle hypertrophy | ||
+ | **PM: lungs are heavy, rubbery and do not collapse (for more, see [[Respiratory Viral Infections - Pathology#Maedi Visna|here]]) | ||
+ | *All result in loss of condition | ||
+ | *Infected animals remain antibody and virus positive | ||
− | + | ====Epidemiology==== | |
+ | *Transfer via '''aerosol, milk or colostrum''' | ||
+ | *Increased risk in '''winter housing''' | ||
− | ''' | + | ====Diagnosis==== |
+ | *Clinical signs | ||
+ | *Serology: '''AGDT'''/'''ELISA''' for '''antibody''' | ||
− | + | ====Control==== | |
− | + | *Seropositive and progeny must be removed from flock | |
− | + | *Farm can be re-accredited after 2 years of clear tests | |
− | + | [[Category:Lentiviruses]][[Category:Sheep]] | |
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− | [[Category:Lentiviruses]] [[Category: |
Revision as of 12:12, 23 May 2010
This article is still under construction. |
Maedi-Visna
Pathogenesis
- Primary replication in lung macrophages
- These then carry infection to brain, lung, udder and/or joints
- T cells react: Type IV immune complex disease
- Target organs become chronically inflamed after 2-6 years
- Visna:
- Inflammation results in demyelination with subacute meningitis around ventricles and choroid plexus
- Posterior paresis progresses for up to a year until sheep can no longer stand
- For more on joint pathology, see here
- Maedi:
- Alveolar septa become infiltrated by lymphocytes and macrophages
- Smooth muscle hypertrophy
- PM: lungs are heavy, rubbery and do not collapse (for more, see here)
- All result in loss of condition
- Infected animals remain antibody and virus positive
Epidemiology
- Transfer via aerosol, milk or colostrum
- Increased risk in winter housing
Diagnosis
- Clinical signs
- Serology: AGDT/ELISA for antibody
Control
- Seropositive and progeny must be removed from flock
- Farm can be re-accredited after 2 years of clear tests