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| + | (BLAD) |
| − | Also known as '''''BLAD'''''
| + | *Occurs in Holstein cattle |
| − | | + | *Missence mutation of -Asp-128-Gly in CD18 molecule |
| − | == Introduction ==
| + | *Recurrent infection, e.g. pneumonia |
| − | | + | [[Category:Primary Innate Immunity Deficiencies]] |
| − | This is an autosomal recessive disorder seen in Holstein Cattle mainly in the USA and is caused by a missence mutation of -Asp-128-Gly in CD18 molecule. It is characterised by premature death and chronic bacterial infections such as recurrent [[:Category:Pneumonia|pneumonia]]. All animals with this mutation can be traced to sire many years ago. In the USA, around 15% of cattle have this mutation.
| + | [[Category:Cattle]] |
| − | | + | [[Category:To Do - Blood]][[Category:To Do - Clinical]] |
| − | Affected calves will appear normal at birth but then become clinically ill within the first few weeks. Life expectancy is generally not more than one year old.
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| − | == Clinical Signs ==
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| − | Chronic recurrent infections such as pneumonia, diarrhoea, dermatitis, gingivitis or vasculitis. The infection will always reappear, even following antibiotic doses usually high enough to cure the infection.
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| − | == Diagnosis ==
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| − | There are tests available in the US to diagnose heterozygous carriers and homozygous calves.
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| − | == Control ==
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| − | Test the herd and eliminate carrier animals.
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| − | {{Learning
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| − | |full text = [http://www.cabi.org/cabdirect/FullTextPDF/2010/20103049446.pdf '''Bovine leukocyte adhesion deficiency syndrome (BLAD): a recessive disorder in Holstein Friesian cattle - a review.''' Vijay Kumar; Ashwani Sharma; Agricultural Research Communication Centre, Karnal, India, Agricultural Reviews, 2009, 30, 4, pp 293-300, many ref.]
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| − | == References ==
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| − | Andrews, A.H, Blowey, R.W, Boyd, H and Eddy, R.G. (2004) Bovine Medicine (Second edition), Blackwell Publishing
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| − | Radostits, O.M, Arundel, J.H, and Gay, C.C. (2000) Veterinary Medicine: a textbook of the diseases of cattle, sheep, pigs, goats and horses Elsevier Health Sciences
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| − | {{review}}
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| − | {{OpenPages}}
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| − | [[Category:Primary_Innate_Immunity_Deficiencies]] [[Category:Lymphoreticular_and_Haematopoietic_Diseases_-_Cattle]] [[Category:Expert_Review - Farm Animal]] | |