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==Viral Characteristics==
 
==Viral Characteristics==
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The genetic information of CAV-1, like other Adenoviridae, is conveyed by a single, linear molecule of double-stranded DNA. This is contained within a non-enveloped icosohedral nucleocapsid, which comprises capsomeres (called hexons) and twelve vertex capsomeres  (called pentons). A fibre antigen which is used to attach to host cell receptors and initiate replication, protrudes from each of the twelve pentons. This fibre antige is a feature specific to the Adenoviridae.  
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The genetic information of CAV-1, like other Adenoviridae, is conveyed by a single, linear molecule of double-stranded DNA which encodes around 30 proteins. Under the influence of both host and virus-encoded factors, the DNA replicates and is transcribed within the host nucleus, where virion assembly also occurs. Basophilic and/or acidophilic inclusions may therefore be seen in the nucleus of an adenovirus-infected cell.
The fiber is the structure of attachment to host cells and is also a type specific hemagglutinin.
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The hexon of mammalian adenoviruses contains a cross-reacting group antigen.
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The fiber antigen attaches to a specific cell receptor and initiates replication.
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The virus genome is contained within a non-enveloped icosohedral nucleocapsid, which comprises capsomeres (called hexons) and twelve vertex capsomeres  (called pentons). A fibre antigen protrudes from each of the twelve pentons, and this attaches to host cell receptors as well as being a type-specific haemagglutinin. This fibre antige is a feature specific to the Adenoviridae. The hexon of mammalian adenoviruses contains a cross-reacting group antigen.
The  dsDNA encodes approximately 30 proteins. Viral DNA replication,  mRNA  transcription and virion assembly occur in the nucleus, utilizing  both  host and virus-encoded factors. This results in the formation of  basophilic and / or acidophilic intranuclear inclusions.
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Many  adenoviruses agglutinate red cells of various animal species  and some  are capable of malignant transformation in tissue culture cell  and  oncogenesis when inoculated into laboratory animals.
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They are resistant to trypsin and lipid solvents, and moderately resistant on premises.
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Figure  13-1. Adenoviridae (70 - 90 nm). Note the fiber proteins protruding  from the vertices of the 12 pentons. To view click on figure
      
==Hosts==
 
==Hosts==
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