Insulin Secreting Neoplasms

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  • Adenomas and carcinomas deerived from beta cells
  • Respond rapidly to iv glucose
  • Can be identified by immunocytochemical means
  • Dogs 5-12 years of age most commonly affected
  • Older cattle, associated with periodic convulsions

Clinical signs

  • Hyperinsulinism
  • Hypoglycaemia - often episodic
    • Neurologic signs - stupor, confusion, coma, seizures, peripheral neuropathy may also develop