Category:Enteritis, Fibrinous/Haemorrhagic
Pathology
- The mucosa eroded to produce lesions of darkish-red submucosa covered in dry, crumbly fibrin.
- Is usually caused by severe damage due to secondary bacterial infection following an earlier milder insult.
- Tends to be more severe in the lower small intestine and upper large intestine.
- Many severe infections tend to get worse further down the gut.
- Catarrhal change may be seen in the upper small intestine and fibrinous change in the lower small intestines.
- In the lower aprt of the bowel, where the inflammation is more severe, disease is more anaerobic.
- Lesions are caused by anaerobic organisms- convert mild diseases into more serious disease.
- Many severe infections tend to get worse further down the gut.
Salmonellosis
Swine Dysentery
- Swine dysentery gives rise to fibrinous/ haemorrhagic enteritis.
- A quite common and important disease.
- The disease is caused by Brachyspira hyodysenteriae.
- Is not seen in gnotobiotic animals - other enteric pathogens such as Fusobacterium or Bacteroides may therefore also be required in order to produce disease.
- The disease is NOT systemic.
- Localised to the large intestine- in particular, the spiral colon.
- Swine dysentery is spread by the faeco-oral route, and is carried by pigs and rodents.
Clinical
- Affects post weaning pigs at approximately 4 months of age.
- White scour becomes a liquid dirty red / brown scour with a foul smell.
- Contains poorly digested focal shreds of mucosa and fibrin strands.
- Mucoid covered faeces.
- Contains poorly digested focal shreds of mucosa and fibrin strands.
- There are three outcomes to infection; the animal may:
- Die
- There is a morbidity up to 90% in the herd, with up to 50% mortality.
- Recover
- Become chronically infected.
- Symptoms are due to loss of absorption in colon.
- The colon is normally a key site of absorption for water and electrolytes in the pig.
Pathology
- The serosa of the spiral colon may appear shiny from the outside.
- Is turgid and oedematous.
- In severe cases, haemorrhage may be seen.
- The small intestine NOT affected.
- Fibrinous deposits are seen on the mucosa as the disease progresses.
- The mucosa underneath is eroded to expose blood vessels in lamina propria.
- Accounts for the bleeding.
- The mucosa underneath is eroded to expose blood vessels in lamina propria.
- Animals often recover, but have a low feed conversion ratio for sometime.
Diagnosis
- Silver stains show organisms in the epithelium of the mucosa.
- Also by immunofluorescence or electron microscopy.
Parvovirus Enteritis
- Parvovirus enteritis is also know as feline infectious enteritis or feline panleucopenia
- Since a vaccine is available, this disease is now uncommon.
- Over the last 10/15 years this has been seen primarily in the cat, but it is now also seen in the dog.
Clinical
- Manifests mainly in cats under 6 months old.
- Common in groups of unvaccinated cats.
- Produces big outbreaks, with vomiting and pyrexia.
- Severe vomiting and diarrhoea occur.
- diarrhoea is thin, watery and foul-smelling, and may also be blood-tinged.
- Animals usually die despite treatment- die from dehydration.
- diarrhoea is thin, watery and foul-smelling, and may also be blood-tinged.
- Animals suffer from fever.
- Pancytopaenia also occures.
- White blood cell count drops very low so as to become almost non-existent.
- Drops to 1/ml from 10000/ml.
- Animals may therefore also die from other infections.
- White blood cell count drops very low so as to become almost non-existent.
Pathology
Gross
- Virus targets crypt cells and lymphoid areas.
- Causes villus atrophy.
- In the cat, the intestine is thickened, turgid and swollen.
- Has a pale, dull and mottled appearance.
- The contents are rather dry - this gets worse lower down the gut.
- Areas of depression in the mucosa can be seen in the upper small bowel.
- Due to necrosis of tissue overlying Peyers patch.
- Lower down in the gut, enteritis is apparent.
- Cat- fibrinous.
- Dog- haemorrhagic.
- Blood in lumen.
- Inflammation sometimes doesn't appear very severe.
- There may be very few lesions
- Histology is usually required for diagnosis.
- A radiomimetic virus.
- Affects all rapidly dividing cells and destroys them.
- E.g. epithelium in the base of the crypts of small intestine are killed.
- Affects all rapidly dividing cells and destroys them.
Histological
- The crypt lining cells undergo complete necrosis, but very little inflammation occurs.
- Collapse of villous architecture.
- May be fibrinous exudates on surface of mucosa.
- The submucosa and lamina propria are not affected and are left intact.
- Many neutrophils in the lamina propria.
- Cyst-like structures are seen in the deepest parts of the glands of the intestinal mucosa, if the animal survives for more than a few days.
- Flattened epithelial cells line these cystic glands.
- Are enterocytes trying to repair the damage.
- However, animals usually die from dehydration or secondary infection before the mucosa recovers.
- Flattened epithelial cells line these cystic glands.
- Inclusion bodies may be seen, but these are very hard to find.
- May get lymphocyte invasion of mucosa.
- Lymph nodes appear pale and oedematous, and almost aplastic.
- Bone marrow appears pale and fatty looking and is depleted of cells.
Canine Disease
- Until 1978 Parvovirus enteriris was totally unknown in dogs.
- First seen in dogs in Australia.
- Apeared very similar but perhaps slightly worse than the disease seen in the cat.
- A new and distinct disease, but the virus is very closely related to the feline virus.
- Viral DNA is 98% homologous to the feline virus.
- The canine virus does NOT cause disease in cats.
- Clinical
- Causes enteritis in young dogs over 6 weeks old.
- Causes myocarditis in puppies.
- Mainly affects the small intestine.
- Vaccines are very effective, but the virus is hardy and survives in the environment.
- Diagnosis:
- Look for viral antigen in the faeces by the red cell agglutination test.
- Immunoflurescence.
- ELISA.
- Serology.
Bacterial septicaemia and enteritis
- Some severe acute septicaemias cause very severe acute haemorrhagic enteritis with bleeding into the alimentary tract.
- Death is usually rapid.
- Fairly easy to diagnose
- small intestine is full of dark, tarry, partly clotted blood (like black currant jelly).
- Associated with severe systemic disease, e.g.
- Anthrax in cattle (Bacillus anthracis).
- Leptospirosis in dogs.
- Especially L. icterohaemorrhagiae.
- Do not confuse with warfarin poisoning.
- Also gives blood in stomach and intestine BUT there are no signs of inflammatory disease.
Lamb Dysentery (Enterotoxaemia with Blood)
- Clostridium perfringens causes very severe acute haemorrhagic enteritis.
- Usually affects young farm animals
- May also be seen in pets.
- Usually affects young farm animals
- Type B Clostridium perfringens infection of lambs leads to lamb dysentery.
Clinical
- Lamb dysentery is usually seen in lambs under 2 weeks of age.
- Related to being kept in a cold, dirty environment, with build-up of infection during the lambing season.
- Lambs may produce bloodstained diarrhoea before death, but they often die before this effect is apparent.
- Diagnosed by culturing contents of gut.
Pathology
Gross
- The gut is blown and distended with foamy ,bloody contents.
- Sometimes ulceration with perforation and fibrinousperitonitis is seen.
- Focal or diffuse congestion and haemorrhages.
Histological
- Coagulative necrosis of villi.
- Oedema.
- Haemorrhage.
- Influx of inflammatory cells in the lamina propria and submucosa.
Similar Conditions
- Piglets show similar disease caused by Clostridium perfringens type C (and sometimes type B)
- May look similar to a volvulus but with no twist present.
- In adult sheep Clostridium perfringens type B infection causes Struck.
- Enterotoxigenic gastritis.
- Acute sudden death with haemorrhagic enteritis
- Haemorrhagic enteritis is not as severe as in lambs, and tends to be more patchy.
Colitis X
- Affects the horse.
- Sudden onset with haemorrhages throughout body (shock) and sometimes acute foul smelling diarhoea.
- colon is acutely haemorhagic and oedematous with mucosal necrosis.
- Associated with Clostridium perfringens.
- Possibly an enterotoxaemia.
Pages in category "Enteritis, Fibrinous/Haemorrhagic"
The following 6 pages are in this category, out of 6 total.