Changes

*Giant breeds of dog are at massively increased risk

*Giant breeds of dog are at massively increased risk

*Clinical signs:

*Clinical signs:

**Painful swellings of bones in mature individuals (contrast with [[Panosteitis|panosteitis]] and [[Bones Hyperplastic and Neoplastic - Pathology#Hypertrophic osteodystrophy|hypertrophic osteodystrophy]])

**Painful swellings of bones in mature individuals (contrast with [[Panosteitis|panosteitis]] and [[Hypertrophic Osteodystrophy|hypertrophic osteodystrophy]])

*Strong site preference in dogs:

*Strong site preference in dogs:

**Appendicular skeleton 3 or 4 times more frequently involved than axial

**Appendicular skeleton 3 or 4 times more frequently involved than axial