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Edendymal cell production of CSF is via ultrafiltration of blood plasma and active transport across the ependymal cells. The ependyma is connected via a series of tight junctions preventing molecules passing between cells. The ependyma also sits on a basement membrane to provide support to the ependymal cells and provide further protection against blood perfusion. In areas of the brain where there are choriod plexus, the endothelium of the plexus vessel sits immediately adjacent to the basement membrane of the ependymal cells.  

Edendymal cell production of CSF is via ultrafiltration of blood plasma and active transport across the ependymal cells. The ependyma is connected via a series of tight junctions preventing molecules passing between cells. The ependyma also sits on a basement membrane to provide support to the ependymal cells and provide further protection against blood perfusion. In areas of the brain where there are choriod plexus, the endothelium of the plexus vessel sits immediately adjacent to the basement membrane of the ependymal cells. Of the total CSF production, 35% is produced within the third ventricle of the brain, 23% via the fourth ventricle and 42% from general ependymal cell filtration production.

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CSF has a very low protein constituent with only albumin being present together with a low level of cellularity. The biochemistry of CSF includes high concentrations of sodium, chloride and very high concentrations of magnesium. Concentrations of potassium, calcium and glucose are low.

CSF has a very low protein constituent with only albumin being present together with a low level of cellularity. The biochemistry of CSF includes high concentrations of sodium, chloride and very high concentrations of magnesium. Concentrations of potassium, calcium and glucose are low.

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==CSF Circulation==

==CSF Circulation==

Once produced, CSF is then circulated from the choroid plexus through the interventricular foramina into the 3rd ventricle, and then through the cerebral aqueduct (aqueduct of Sylvius) into the 4th ventricle before flowing through the cerebromedullary cistern down the spinal cord and over the cerebral hemispheres. Most CSF escapes from the ventricular system at the hindbrain foramen of Luschka. CSF then flows down the length of the spinal cord in the subarachnoid space.  

Once produced, CSF is then circulated from the choroid plexus through the interventricular foramina into the 3rd ventricle, and then through the cerebral aqueduct (aqueduct of Sylvius) into the 4th ventricle before flowing through the cerebromedullary cistern down the spinal cord and over the cerebral hemispheres. Most CSF escapes from the ventricular system at the hindbrain foramen of Luschka. CSF then flows down the length of the spinal cord in the subarachnoid space.