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| ** <Font Color="#9900ff">'''Function Unknown'''</Font> | | ** <Font Color="#9900ff">'''Function Unknown'''</Font> |
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− | ==Function==
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| * They allow the reabsorption of water, glycerol and chlorine from the filtrate | | * They allow the reabsorption of water, glycerol and chlorine from the filtrate |
| * Without them producing concentrated urine would be impossible | | * Without them producing concentrated urine would be impossible |
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| + | ==[[Endocrine System - Pituitary Gland - Anatomy & Physiology #Posterior Pituitary Gland| ADH]]== |
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| * AQP2 is stored in vesicle membranes within the [[Collecting Duct - Anatomy & Physiology #Principal Cells| principal cells]] of the [[Collecting Duct - Anatomy & Physiology| collecting ducts]] | | * AQP2 is stored in vesicle membranes within the [[Collecting Duct - Anatomy & Physiology #Principal Cells| principal cells]] of the [[Collecting Duct - Anatomy & Physiology| collecting ducts]] |
| * [[Endocrine System - Pituitary Gland - Anatomy & Physiology #Posterior Pituitary Gland| ADH]] causes these vesicles to attach to the principal cell membranes. | | * [[Endocrine System - Pituitary Gland - Anatomy & Physiology #Posterior Pituitary Gland| ADH]] causes these vesicles to attach to the principal cell membranes. |
− | * This is how ADH works.
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| ** The higher its concentration the more AQP2 bind to principal cell membranes therefore the more AQP2 available to water within the collecting duct | | ** The higher its concentration the more AQP2 bind to principal cell membranes therefore the more AQP2 available to water within the collecting duct |
| ** The more water is reabsorbed | | ** The more water is reabsorbed |
| ** Thanks to the gradient created by the hypertonic medulla which is present due to the countercurrent multiplier in the [[Loop Of Henle - Anatomy & Physiology| Loop of Henle]] | | ** Thanks to the gradient created by the hypertonic medulla which is present due to the countercurrent multiplier in the [[Loop Of Henle - Anatomy & Physiology| Loop of Henle]] |
| * This system allows both concentrated and dilute urine to be produced depending on ADH secretion and therefore the density of aquaporins in the principal cell membranes | | * This system allows both concentrated and dilute urine to be produced depending on ADH secretion and therefore the density of aquaporins in the principal cell membranes |
| + | * Without ADH the collecting duct would remain impermeable to water and as a result water and salt would be lost and wasted. |
| + | * This would result in an increase in plasma osmolarity |
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| ==Species Variation of the Ability to Conserve Water== | | ==Species Variation of the Ability to Conserve Water== |